Chemistry and Molecular PharmacologyLaboratory of Molecular Biophysics

Laboratory of Molecular Biophysics

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Slebe F, Rojo F, Vinaixa M, García-Rocha M, Testoni G, Guiu M, Planet E, Samino S, Arenas EJ, Beltran A, Rovira A, Lluch A, Salvatella X, Yanes O, Albanell J, Guinovart JJ and Gomis RR.
Nat Commun, 7 11199 (2016)
Fenwick RB, Orellana L, Esteban-Martín S, Orozco M and Salvatella X.
Nat Commun, 5 4070 (2014)
Candotti M, Esteban-Martín S, Salvatella X and Orozco M.
P Natl Acad Sci Usa, 110 (15), 5933-8 (2013)
Fenwick RB, Esteban-Martín S, Richter B, Lee D, Walter KF, Milovanovic D, Becker S, Lakomek NA, Griesinger C and Salvatella X.
J Am Chem Soc, 133 (27), 10336-9 (2011)
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM and Salvatella X.
Angew Chem Int Edit, 50 (31), 7048-51 (2011)
Esteban-Martín S, Fenwick RB and Salvatella X.
J Am Chem Soc, 132 (13), 4626-32 (2010)
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM and Salvatella X.
J Mol Biol, 402 (5), 783-96 (2010)

This group is financially supported by the following:

  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Xavier Salvatella (Photo: Battista/MinocriIRB Barcelona)</p>
12 Des 2017

La Corporació Catalana de Mitjans Audiovisuals, La Razón i Aldia.cat han destacat, al seu web, l’estudi de Xavier Salvatella, investigador ICREA de l’IRB Barcelona, que proposa atacar el càncer de

<p>The image shows interactions between the androgen receptor protein (AR) and the TFIIF protein in red. (Author: Paula Martínez-Cristóbal)</p>
12 Des 2017

En la majoria del casos, el càncer de pròstata es cura extirpant el tumor amb cirurgia i/o amb radioteràpia.

<p>CPEB4 liquid-like droplets in the cell cytoplasm (J. Guillén-Boixet, IRB Barcelona)</p>
21 Nov 2016

Les "liquid-like droplets" (gotes líquides) són acumulacions molt dinàmiques i sense estructura aparent de proteïnes al citoplasma cel·lular que en els últims dos anys estan acaparant prot

Upcoming events

27 Jul
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Evripidis Gavathiotis, PhD – Associate Professor – Department of Biochemistry – Department of Medicine – Center for Experimental Therapeutics Albert Einstein Cancer Research – Wilf Family Cardiovascular Research Institute – Institute of Aging Research – N