Vés al contingut
Mecanismes de Malaltia
Laboratory of Molecular Biophysics
Imatge
Group Leader
Telephone:
+34 93 40 20459

ICREA Research Professor, ERC Consolidator Grant

Imatge
Imatge
ICREA

Meet Our Scientists Videos

Research information

Background

A high resolution description of the structure and dynamics of proteins is a very useful tool to study the properties and the function of these important biomacromolecules and, most importantly, to understand how changes in sequence or environment can lead to disease. The research work carried out at the Laboratory of Molecular Biophysics aims, on the one hand, at developing methods to probe the fluctuations of the structure of proteins by combining experimental data and molecular simulations and, on the other hand, at understanding how changes in such motions relate to the molecular recognition of proteins, to their function and disease.

Selected publications

Biesaga M; Frigolé-Vivas M; Salvatella X
Current Opinion In Chemical Biology
62
( )
90 -
100
(2021)
Garcia-Cabau C; Salvatella X
Current Opinion In Cell Biology
69
( )
111 -
119
(2021)
Eftekharzadeh B; Banduseela V; Chiesa G; Martínez-Cristóbal P; Rauch J; Nath S; Schwarz D; Shao H; Marin-Argany M; Di Sanza C; Giorgetti E; Yu Z; Pieratelli R; Felli I; Brun-Heath I; García J; Nebreda Á; Gestwicki J; Lieberman A; Salvatella X
Nature Communications
10
(1 )
3562 -
(2019)
Escobedo A; Topal B; Kunze M; Aranda J; Chiesa G; Mungianu D; Bernardo-Seisdedos G; Eftekharzadeh B; Gairí M; Pierattelli R; Felli I; Diercks T; Millet O; García J; Orozco M; Crehuet R; Lindorff-Larsen K; Salvatella X
Nature Communications
10
(1 )
2034 -
(2019)
Bouchard J; Otero J; Scott D; Szulc E; Martin E; Sabri N; Granata D; Marzahn M; Lindorff-Larsen K; Salvatella X; Schulman B; Mittag T
Molecular Cell
72
(1 )
19 -
36.e8
(2018)
De Mol E; Szulc E; Di Sanza C; Martínez-Cristóbal P; Bertoncini C; Fenwick R; Frigolé-Vivas M; Masín M; Hunter I; Buzón V; Brun-Heath I; García J; De Fabritiis G; Estébanez-Perpiñá E; McEwan I; Nebreda Á; Salvatella X
Structure
26
(1 )
145 -
152.e3
(2018)
Guillén-Boixet J; Buzon V; Salvatella X; Méndez R
Elife
5
(NOVEMBER2016 )
-
(2016)
Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X
Biophysical Journal
110
(11 )
2361 -
2366
(2016)
De Mol E, Fenwick RB, Phang CT, Buzón V, Szulc E, de la Fuente A, Escobedo A, García J, Bertoncini CW, Estébanez-Perpiñá E, McEwan IJ, Riera A, Salvatella X
Acs Chemical Biology
11
(9 )
2499 -
505
(2016)
Fenwick R; Orellana L; Esteban-Martín S; Orozco M; Salvatella X
Nature Communications
5
(4070 )
4070 -
(2014)

Projects

“ARtin. Discovery of new inhibitors of the disordered domain of the androgen receptor to treat castration-resistant prostate cancer”. El proyecto ARtin, con código INNO20010FRIG, ha recibido financiación del programa AECC Innova promovido por la Fundación Científica AECC

Group members

Group Leader
Research Assistant
Postdoctoral Fellow
PhD Student
PhD Student
PhD Student
PhD Student
Senior Research Officer
Lab Technician
Visiting Student

Group News