Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology
Group Leader

ICREA Research Professor, ERC Consolidator Grant

+34 93 40 39690

Meet Our Scientists Videos

Patrick Aloy: "Xarxes de vida"

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Jaeger S, Igea A, Arroyo R, Alcalde V, Canovas B, Orozco M, Nebreda AR and Aloy P.
Cancer Res, 77 (2), 459-469 (2017)
Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P and Orozco M.
Structure, 24 (1), 116-26 (2016)
Duran-Frigola M, Rossell D and Aloy P.
Nat Commun, 5 5676 (2014)
Mosca R, Céol A and Aloy P.
Nat Methods, 10 (1), 47-53 (2013)
Duran-Frigola M, Mosca R and Aloy P.
Chem Biol, 20 (5), 674-84 (2013)
Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 11 (7), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 21 (3), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 6 (5), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 11 (12), 977-84 (2010)

This group receives financial support from the following sources:

  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"


Group news & mentions

<p>Science Festival 2016, Parc de la Ciutadella.</p>
24 Mai 2017

Els propers 27 i 28 de maig, el Parc de la Ciutadella de Barcelona serà l'amfitrió de l’onzena edició de la Festa de la Ciència, un esdeveniment consolidat que reuneix prop d’un centenar d'activita

9 Feb 2017

La revista bimensual Clinical OMICs entrevista a Patrick Aloy, investigador ICREA i líder del Laboratori de Bioinformàtica Estructural i Biologia de Xarxes a l'IRB Barcelona, sobre el seu estudi pu

31 Gen 2017

Patrick Aloy, investigador ICREA de l'IRB Barcelona , ha dit a 'L'Entrevista' de La Xarxa Televisió, que la recerca en Alzheimer està en la fase d'entendre la mal

<p>Patrick Aloy, ICREA Research Professor & ERC Consolidator Grant.</p>
31 Des 2016

El diari local Regió 7 dedica un article a l'estudi dirigit per Patrick Aloy, investigador ICREA i líder del laboratori de Bioinformàtica Estructural i Biologia de Xarxes de l'IRB Barcelona.

Upcoming events

13 Abr
Aula Fèlix Serratosa, Parc Científic de Barcelona
Dr Samir Merabet, Team leader. Institut de génomique fonctionnelle de Lyon, CNRS/ENS Lyon, France.
27 Abr
Serratosa Room, Parc Científic de Barcelona
Dr Michal Sharon – Structural Mass Spectrometry – Weizmann Institute of Science - Israel