Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology
Group Leader

ICREA Research Professor, ERC Consolidator Grant

+34 93 40 39690

Meet Our Scientists Videos

Patrick Aloy: "Networks of Life"

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Jaeger S, Igea A, Arroyo R, Alcalde V, Canovas B, Orozco M, Nebreda AR and Aloy P.
Cancer Res, 77 (2), 459-469 (2017)
Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P and Orozco M.
Structure, 24 (1), 116-26 (2016)
Duran-Frigola M, Rossell D and Aloy P.
Nat Commun, 5 5676 (2014)
Mosca R, Céol A and Aloy P.
Nat Methods, 10 (1), 47-53 (2013)
Duran-Frigola M, Mosca R and Aloy P.
Chem Biol, 20 (5), 674-84 (2013)
Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 11 (7), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 21 (3), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 6 (5), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 11 (12), 977-84 (2010)

This group receives financial support from the following sources:

  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>Guiomar Solanas, research associate at the Stem Cells and Cancer Lab</p>
11 May 2018

Three scientists from IRB Barcelona have been awarded "To the Mothers of Science" fellowships from the Barcelona Institute of Science and Technology (BIST).

<p>Patrick Aloy, Group Leader of the Structural Bioinformatics and Network Biology Lab</p>
20 Mar 2018

Patrick Aloy, Group Leader of the Structural Bioinformatics and Network Biology Lab at IRB Barcelona participated in the "Càpsules de ciència” video series produced by TV3.

<p>Science Festival 2016, Parc de la Ciutadella.</p>
24 May 2017

This year the Parc de la Ciutadella in Barcelona will be hosting the eleventh edition of the Science Festival.

<p>Patrick Aloy, Group Leader of the Structural Bioinformatics and Network Biology Lab</p>
9 Feb 2017

The bimonthly magazine Clinical OMICs interviews Patrick Aloy, ICREA researcher and leader of the Structural Bioinformatics and Network Biology lab at IRB Barcelona, about his study published in th

Upcoming events

27 Jul
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Evripidis Gavathiotis, PhD – Associate Professor – Department of Biochemistry – Department of Medicine – Center for Experimental Therapeutics Albert Einstein Cancer Research – Wilf Family Cardiovascular Research Institute – Institute of Aging Research – N