Structural and Computational BiologyStructural Bioinformatics and Network Biology

"For every complex problem there's an answer that is clear, simple, and wrong". H.L. Mencken.

Structural Bioinformatics and Network Biology
Group Leader

ICREA Research Professor, ERC Consolidator Grant

+34 93 40 39690

Meet Our Scientists Videos

Patrick Aloy: "Networks of Life"

Modern molecular and cell biology no longer focus only on single macromolecules but now look into pathways, complexes or even entire organisms. The many genome-sequencing projects have provided a near complete list of the components present in an organism, and post-genomic projects have aimed to catalogue the relationships between them.

The emerging field of systems biology is now centered mainly on unravelling these relationships. For example, an understanding of metabolic and signalling pathways or gene-regulatory networks relies on detailed knowledge of protein–metabolite, protein–protein and protein–nucleic-acid interactions. However, a full understanding of how molecules interact can be attained only from three-dimensional (3D) structures, as these provide crucial atomic details about binding. These details allow a more rational design of experiments to disrupt an interaction and therefore to perturb any system in which the interaction is involved.

Structural Bioinformatics and Network Biology Group Webpage

Our main scientific interests lie in the field of structural bioinformatics, in particular, the use of high-resolution 3D structures to reveal the molecular bases of how macromolecular complexes and cell networks operate. Structural information for interacting cellular components willimprove our understanding of the whole-cell framework at atomic level, thereby contributing to biological systems modelling.

Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P and Orozco M.
Structure, 24 (1), 116-26 (2016)
Duran-Frigola M, Rossell D and Aloy P.
Nat Commun, 5 5676 (2014)
Mosca R, Céol A and Aloy P.
Nat Methods, 10 (1), 47-53 (2013)
Duran-Frigola M, Mosca R and Aloy P.
Chem Biol, 20 (5), 674-84 (2013)
Mosca R, Pache RA and Aloy P.
Mol Cell Proteomics, 11 (7), M111.01496 (2012)
Soler-López M, Zanzoni A, Lluís R, Stelzl U and Aloy P.
Genome Res, 21 (3), 364-76 (2011)
Stein A and Aloy P.
Plos Comput Biol, 6 (5), e1000789 (2010)
Sardon T, Pache RA, Stein A, Molina H, Vernos I and Aloy P.
Embo Rep, 11 (12), 977-84 (2010)

This group receives financial support from the following sources:

  • ICREA (Institució Catalana de Recerca i Estudis Avançats)(Catalan Institute of Research and Advanced Studies)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

9 Feb 2017

The bimonthly magazine Clinical OMICs interviews Patrick Aloy, ICREA researcher and leader of the Structural Bioinformatics and Network Biology lab at IRB Barcelona, about his study published in th

31 Jan 2017

Patrick Aloy, ICREA researcher at IRB Barcelona, has told the programme 'L'Entrevista', broadcasted by “La Xarxa Televisió”, that research into Alzheimer’s diseas

<p>Patrick Aloy, ICREA Research Professor &amp; ERC Consolidator Grant.</p>
31 Dec 2016

The local newspaper “Regió 7” devotes an article to the study headed by Patrick Aloy, ICREA researcher and leader of the Structural Bioinformatics and Network Biology lab at IRB Barcelona.

23 Dec 2016

United Press International publishes an extensive article about the study headed by Patrick Aloy, ICREA researcher and leader of the Structural Bioinformatics and Network Biology Lab at IRB Barcelo

Upcoming events

22 Feb
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Silvia Zorilla, CIB-CSIC
22 Feb
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Julián Cerón Madrigal, PhD - Bellvitge Biomedical Research Institute, IDIBELL
23 Feb
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Toni Celià-Terrassa, PhD. Department of Molecular Biology, Princenton University, NJ (USA)