Signalling and Cell Cycle Laboratory

Dr. Angel R. Nebreda

Group Leader

Telephone:

+34 93 40 31379

Email:

angel.nebreda@irbbarcelona.org

ICREA Research Professor, ERC Advanced Grant

Research information

Background

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

Mechanisms of signal integration by p38 MAP kinases and their role in cancer
Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.

Selected publications

MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate

Gutierrez-Prat, N; Cubillos-Rojas, M; Canovas, B; Kuzmanic, A; Gupta, J; Igea, A; Llonch, E; Gaestel, M; Nebreda, AR

Proceedings Of The National Academy Of Sciences Of The United States Of America

118

(29 )

(2021)

Diversity and versatility of p38 kinase signalling in health and disease

Canovas B; Nebreda AR

Nature Reviews Molecular Cell Biology

(5 )

346 -

366

(2021)

Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation

Donoghue C; Cubillos-Rojas M; Gutierrez-Prat N; Sanchez-Zarzalejo C; Verdaguer X; Riera A; Nebreda AR

European Journal Of Medicinal Chemistry

201

(112451 )

112451 -

(2020)

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Vitos-Faleato J, Real SM, Gutierrez-Prat N, Villanueva A, Llonch E, Drosten M, Barbacid M, Nebreda AR

Proceedings Of The National Academy Of Sciences Of The United States Of America

117

(5 )

2588 -

2596

(2020)

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

Batlle R; Andrés E; Gonzalez L; Llonch E; Igea A; Gutierrez-Prat N; Berenguer-Llergo A; Nebreda A

Nature Communications

(3071 )

3071 -

(2019)

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis

Curtis M; Kenny HA; Ashcroft B; Mukherjee A; Johnson A; Zhang Y; Helou Y; Batlle R; Liu X; Gutierrez N; Gao X; Yamada SD; Lastra R; Montag A; Ahsan N; Locasale JW; Salomon AR; Nebreda AR; Lengyel E

Cell Metabolism

(1 )

141 -

(2019)

Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis

Youssif C; Cubillos-Rojas M; Comalada M; Llonch E; Perna C; Djouder N; Nebreda A

Embo Molecular Medicine

(7 )

(2018)

Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells

Cánovas B; Igea A; Sartori A; Gomis R; Paull T; Isoda M; Pérez-Montoyo H; Serra V; González-Suárez E; Stracker T; Nebreda A

Cancer Cell

(6 )

1094 -

(2018)

Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y, Nebreda AR

Nature Communications

(11084 )

11084 -

(2016)

The stress kinase p38α as a target for cancer therapy

Igea A; Nebreda A

Cancer Research

(19 )

3997 -

4002

(2015)

Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival

Gupta J; delBarcoBarrantes I; Igea A; Sakellariou S; Pateras I; Gorgoulis V; Nebreda A

Cancer Cell

(4 )

484 -

500

(2014)

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

Pereira L; Igea A; Canovas B; Dolado I; Nebreda A

Embo Molecular Medicine

(11 )

1759 -

1774

(2013)

SnapShot: P38 MAPK substrates

Trempolec N; Dave-Coll N; Nebreda A

Cell

152

(4 )

924 -

924.e1

(2013)

Projects

"Regulacion de la tumorigénesis por quinasas de estrés: p38a en la homeostasis de las células tumorales y su interacción con las celulas del estroma" cofinanciado por el Ministerio de Economia y Competitividad y por el Fondo Europeo de Desarrollo Regional (FEDER). Referencia: SAF2016-81043-R (MINECO/FEDER, UE).

"Role of p38α MAPK in cancer cell metabolism during tumor development" financiado por el Worldwide Cancer Research (WCR). Referencia: 18-0666

Grup de Recerca consolidat (SGR 2017-2019) de la Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement de la Generalitat de Catalunya. Agencia de Gestió d'Ajuts Universitaris i de Recerca (AGAUR). Referencia: 2017 SGR 557

"Tumor immunosupression by myeloid p38a signaling; implications for melanoma therapy" financiado por la Fundación Científica AECC. Referencia: PROYE18035RODR

"Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity" (p38_InTh), financiado por el European Research Council (ERC) mediante el Programa de Investigación e Innovación de la Unión Europea Horizonte 2020. Referencia: 825763

"NC-p38i-II: Nous candidats per evitar el dany de les cèl·lules cardíaques" funded by the European Union through the European Regional Development Fund (FEDER) with the support of the Secretaria d’Universitats i Recerca, Departament d’Empresa i Coneixement, Generalitat de Catalunya. Ref: 2019PROD00138

"Búsqueda de vulnerabilidades en los tumores para mejorar la terapia contra el cáncer: señalización por p38a en la respuesta a la quimioterapia" funded by the Ministerio de Ciencia e Innovación. Ref: PID2019-109521RB-I00