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IRB Research Nodes Seminar

3 Apr 24

IRB Research Nodes Seminar 

[Double External session]


Wednesday, April 3, 2024 - 12:00  

Auditorium Room





Speakers:  Dr. Sarah Bray & Dr. Nick Brown

Host: Dr. Marco Milan - Development and Growth Control Laboratory - IRB Barcelona

Node: Cell Pathophysiology

Date: Wednesday 3 April 2024, 12:00h

Place: Auditorium Room


IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar.


Sarah Bray

Dr. Sarah Bray
Professor of Developmental Biology, Joint Head of Department - Wellcome Trust Investigator, Department of Physiology, Development and Neuroscience
University of Cambridge
Cambridge (UK)

Nick Brown

Dr. Nick Brown
Professor of Cell Biology, Department of Physiology, Development and Neuroscience
University of Cambridge
Cambridge (UK)


Talk 1

Title: Decoding notch signals

Speaker: Dr. Sarah Bray

Abstract: To make and organize different tissues, cells decipher information from developmental signalling pathways. Transmitting this information accurately, so that cell-surface signals are translated into correct transcriptional responses, is of critical importance. For example, dosage and dynamics of Notch activity are fundamentally important for developmental decisions, for sustaining stem cells and for tissue homeostasis. Mis-regulation underlies many diseases including cancers. One of our goals is to better understand how cells decode signals to generate accurate transcriptional responses in the context of the Notch pathway. To do so we are combining different live imaging approaches to follow transcription complexes in real time and to measure the dynamic transcriptional response of target-genes in different decision-making contexts in the embryo. Integrating the results from these two avenues, we are learning how Notch signals are decoded and implemented, giving insights into how this may be misrouted in disease.

Talk 2

Title: Evolutionary and developmental transitions in cell adhesion mechanisms

Speaker: Dr. Nick Brown 

Abstract: I will introduce the two fundamental cell adhesion mechanisms involving cadherins and integrins, and discuss their contributions to development. I will present recent work exploring the evolution of cell adhesion mechanisms, the integrated function of cadherins and integrins in cell adhesion, and the role of the mechanoeffector vinculin.