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Massively Parallel Human Systems Biology in Synthetic Organisms

11 Oct 19

Speaker: Jesse Rinehart, PhD, Associate Professor of Cellular & Molecular Physiology. System Biology Institute. Yale University School of Medicine. CT 06520. USA



Organizers: IRB Barcelona
Date: Friday 11 October, 12.00h
Place: Felix Serratosa Hall, Parc Cientific de Barcelona

Host: Lluís Ribas de Pouplana, PhD - IRB Barcelona


Protein phosphorylation encompasses a central cellular language that determines every facet of normal cellular biology. We have recently created a technology that enables site-specific incorporation of phosphoserine into proteins by expanding the genetic code of Escherichia coli.  I will describe our new capability to synthesize and observe phosphoproteome-scale libraries of human phosphoproteins that enable answers to systems level questions regarding the functional role of all human phosphorylation events.  Our work has also advanced the protein-protein interaction field by enabling the first system for large-scale genetic screening of phosphorylation dependent protein-protein interactions. 

Plenary Seminar