Presentation
Organizer: IRB BioMed Seminars
Date / Time: Friday, January 23 at 12:00
Place: Auditorium
Speaker: Professor Rocío Sotillo, Group Leader of Molecular Thoracic Oncology, Functional and Structural Genomics, German Cancer Research Center.
Host: Dr. Lluís Ribas, Group Leader IRB Barcelona - Gene Translation Lab - Aging and Metabolism Programme.
I will describe how oncogenic fusion diversity and endogenous mutational processes shape tumour evolution and therapy response. Using CRISPR/Cas9 somatic genome editing, we generated mouse and organoid models of the major EML4-ALK variants in lung cancer. These studies reveal striking variant-specific differences in oncogenic potential, tumour suppressor interactions, and sensitivity to ALK inhibition.
In parallel, I will present data on APOBEC3B (A3B) in HER2-driven breast cancer, showing that A3B acts as both a mutagenic and selective force. High A3B expression delays tumour initiation through early DNA-damage–induced bottlenecks, yet ultimately drives chromosomal instability and aggressive evolution.
IMPORTANT: For attendees outside the PCB community you must register at least 24h before the seminar
The weekly seminars at IRB Barcelona are scientific events primarily addressed to the Institute’s research community and professionals in the biomedical field. Attendance is intended exclusively for individuals with a genuine and justified scientific interest in the seminar content. Registration should not be used to request supporting documents for visa or immigration purposes. For participants residing outside Spain, in-person attendance requires a formal invitation issued by an IRB Barcelona research group or department. Without such an invitation, access to the institute cannot be guaranteed. IRB Barcelona reserves the right to review and verify all seminar registrations.