The role of disorder
Speaker: Prof. Jane Clarke Professor of Molecular Biophysics, Department of Chemistry, University of Cambridge, Cambridge, UK
Organizers: IRB Barcelona
Date: Friday 13 July, 12.00h
Place: Aula Fèlix Serratosa, Parc Científic de Barcelona, Spain
Host: Dr. Xavier Salvatella (IRB Barcelona)
Intrinsically disordered proteins (IDPs) are central to many signalling and regulatory networks in the cell. Some (such as nucleoporins) function through binding specifically to ligands although they remain disordered and dynamic even when bound. Other IDPs fold to specific structures as they transiently bind partner macromolecules. Multidisciplinary studies have been essential to understand why Biology would utilise disordered molecules to play such a key role in cellular function.