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A reservoir of stem cells in the intestine

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EFE Agency and other media have echoed the research performed by scientists at IRB Barcelona headed by ICREA researcher Eduard Batlle, leader of the Colorectal Cancer Laboratory. The first author is Francisco Barriga, current postdoctoral fellow at Memorial Sloan Kettering Cancer Center in New York.

Published in Cell Stem Cell, the study identifies a new group of intestinal stem cells with very different characteristics to those of the abundant and active stem cells already known in this organ. It is a small group of passive stem cells—quiescent. These cells are activated when needed, such as in situations of stress, like after chemotherapy, in inflammatory processes, and in tissue infections and have the capacity to produce any kind of intestinal cell and are thus relevant for tissue regeneration.

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About IRB Barcelona

The Institute for Research in Biomedicine (IRB Barcelona) pursues a society free of disease. To this end, it conducts multidisciplinary research of excellence to cure cancer and other diseases linked to ageing. It establishes technology transfer agreements with the pharmaceutical industry and major hospitals to bring research results closer to society, and organises a range of science outreach activities to engage the public in an open dialogue. IRB Barcelona is an international centre that hosts 400 researchers and more than 30 nationalities. Recognised as a Severo Ochoa Centre of Excellence since 2011, IRB Barcelona is a CERCA centre and member of the Barcelona Institute of Science and Technology (BIST).