An 'interpreter' of relevant mutations
Diario Médico has published an article on the "Cancer Geneme Interpreter" (CGI) that includes statements by Nuria López-Bigas, head of the Biomedical Genomics Lab at IRB Barcelona. The CGI is an open platform on the Internet that automates the interpretation of genomic alterations in specific tumours, reporting their relationship with tumour onset. This platform has been developed by researchers from IRB Barcelona and the Vall d'Hebrón Institute of Oncology.
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Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells.
The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.
Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
The newspaper La Tribuna de Albacete has interviewed IRB Barcelona researcher Erika López Arribillaga about a grant awarded to her on 24 September by the Spanish Association Against Cancer (AECC). López Arribillaga’s project aims to unravel the long-term effects of some chemotherapy treatments on colorectal cancer patients.
Link to La Tribuna de Albacete
