The Huffington Post publishes an extensive report on cancer-causing mutations, with a special focus on random DNA errors that occur when self-renewing cells divide, according to a recent paper published in Science by researchers at Johns Hopkins University.
The report includes declarations of several experts on cancer studies, among them IRB Barcelona research associates Elena Sancho, in the Colorectal Cancer Lab, and Gloria Pascual, in the Stem Cells and Cancer Lab. "Does this means that we can do as we please because whatever we do, we'll have the same probability of having cancer? The answer is a resounding no", stresses Elena Sancho.
Link to The Huffington Post
Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
The newspaper ABC has reported on a new project to be launched by IRB Barcelona researcher Roger Gomis thanks to a grant from the Fundación Fero y Mango. Focusing on luminal breast cancer, one of the most common subtypes, the project aims to decipher the “dialogue” between tumour cells and bone stem cells. This information can then be used to design therapeutic targets and to limit the capacity of these cells to metastasize. “This is a groundbreaking approach to tackle metastasis in this kind of cancer,” says Gomis.
The newspaper La Tribuna de Albacete has interviewed IRB Barcelona researcher Erika López Arribillaga about a grant awarded to her on 24 September by the Spanish Association Against Cancer (AECC). López Arribillaga’s project aims to unravel the long-term effects of some chemotherapy treatments on colorectal cancer patients.
Link to La Tribuna de Albacete
