CPEB4 links the clock and the UPR to protect the liver


Paul C. Moore and Scott A. Oakes write a "News and Views" article in Nature Cell Biology February's issue about the findings recently published by Maíllo et al, in Raúl Méndez laboratory, in the same journal on the role of CEPB4 in the liver. Under the title "CPEB4 links the clock and the UPR to protect the liver", the researchers at the Diabetes Center, and Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco, explain that the IRB Barcelona study uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

Reference article:

Paul C. Moore & Scott A. Oakes

CPEB4 links the clock and the UPR to protect the liver

Nature Cell Biology (2017) doi:10.1038/ncb3460

RELATED INFO:

Article by Maillo at al: http://www.nature.com/ncb/journal/v19/n2/full/ncb3461.html

IRB Barcelona press release: Researchers discover a protein that protects against fatty liver