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Research

At the forefront of biomedicine

Lorena Gonzalez

Gonzalez
Unit:
Position:
Alumni - Postdoctoral Fellow
Office:
EM01B53-4-C53
Telephone:
+34 93 40 20596
Left IRB Barcelona in December 2021
Research Group

Selected group publications

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α
Pous, J; Baginski, B; Martin-Malpartida, P; González, L; Scarpa, M; Aragon, E; Ruiz, L; Mees, RA; Iglesias-Fernández, J; Orozco, M; Nebreda, AR; Macias, MJ
Nature Communications,
14
(1 )
7920
(2023)
Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway
González, L; Díaz, L; Pous, J; Baginski, B; Duran-Corbera, A; Scarpa, M; Brun-Heath, I; Igea, A; Martin-Malpartida, P; Ruiz, L; Pallara, C; Esguerra, M; Colizzi, F; Mayor-Ruiz, C; Biondi, RM; Soliva, R; Macias, MJ; Orozco, M; Nebreda, AR
Nature Communications,
14
(1 )
3318
(2023)
Characterization of p38α signaling networks in cancer cells using quantitative proteomics and phosphoproteomics
Dan, YZ; Radic, N; Gay, M; Fernández-Torras, A; Arauz, G; Vilaseca, M; Aloy, P; Canos, B; Nebreda, AR
MOLECULAR & CELLULAR PROTEOMICS,
22
(4 )
100527
(2023)
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate
Gutierrez-Prat, N; Cubillos-Rojas, M; Canovas, B; Kuzmanic, A; Gupta, J; Igea, A; Llonch, E; Gaestel, M; Nebreda, AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
118
(29 )
e2024562118
(2021)
Diversity and versatility of p38 kinase signalling in health and disease
Canovas, B; Nebreda, AR
NATURE REVIEWS MOLECULAR CELL BIOLOGY,
22
(5 )
346
- 366
(2021)
Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation
Donoghue, C; Cubillos-Rojas, M; Gutierrez-Prat, N; Sanchez-Zarzalejo, C; Verdaguer, X; Riera, A; Nebreda, AR
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,
201
112451
(2020)
Requirement for epithelial p38α in KRAS-driven lung tumor progression
Vitos-Faleato, J; Real, SM; Gutierrez-Prat, N; Villanueva, A; Llonch, E; Drosten, M; Barbacid, M; Nebreda, AR
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
117
(5 )
2588
- 2596
(2020)
Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
Batlle, R; Andrés, E; Gonzalez, L; Llonch, E; Igea, A; Gutierrez-Prat, N; Berenguer-Llergo, A; Nebreda, AR
Nature Communications,
10
(1 )
3071
(2019)
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis
Youssif, C; Cubillos-Rojas, M; Comalada, M; Llonch, E; Perna, C; Djouder, N; Nebreda, AR
EMBO Molecular Medicine,
10
(7 )
e8403
(2018)