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At the forefront of biomedicine

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Research publications

Clonal analysis of lineage fate in native haematopoiesis
Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo
2018
The transcriptome of human oocytes is related to age and ovarian reserve
Barragán M; Pons J; Ferrer-Vaquer A; Cornet-Bartolomé D; Schweitzer A; Hubbard J; Auer H; Rodolosse A; Vassena R
23
8
535 -
548
2017
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas G; Peixoto FO; Perdiguero E; Jardí M; Ruiz-Bonilla V; Datta D; Symeonidi A; Castellanos A; Welz PS; Caballero JM; Sassone-Corsi P; Muñoz-Cánoves P; Benitah SA
170
4
678 -
692.e20
2017
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging
Sato S; Solanas G; Peixoto FO; Bee L; Symeonidi A; Schmidt MS; Brenner C; Masri S; Benitah SA; Sassone-Corsi P
170
4
664 -
677.e11
2017
The dynamic assembly of distinct RNA polymerase i complexes modulates rDNA transcription
Torreira E; Louro J; Pazos I; González-Polo N; Gil-Carton D; Duran A; Tosi S; Gallego O; Calvo O; Fernández-Tornero C
6
e20832
-
2017
Tetraspanin 6: A pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Guix FX; Sannerud R; Berditchevski F; Arranz AM; Horré K; Snellinx A; Thathiah A; Saido T; Saito T; Rajesh S; Overduin M; Kumar-Singh S; Radaelli E; Corthout N; Colombelli J; Tosi S; Munck S; Salas IH; Annaert W; De Strooper B
12
1
25 -
2017
Structure of the homodimeric androgen receptor ligand-binding domain
Nadal M; Prekovic S; Gallastegui N; Helsen C; Abella M; Zielinska K; Gay M; Vilaseca M; Taulès M; Houtsmuller A; Van Royen M; Claessens F; Fuentes-Prior P; Estébanez-Perpiñá E
8
14388
14388 -
2017
Polarized cortical tension drives zebrafish epiboly movements
Hernández-Vega A; Marsal M; Pouille P; Tosi S; Colombelli J; Luque T; Navajas D; Pagonabarraga I; Martín-Blanco E
36
1
25 -
41
2017
An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth
Rossi F; Molnar C; Hashiyama K; Heinen J; Pampalona J; Llamazares S; Reina J; Hashiyama T; Rai M; Pollarolo G; Fernández-Hernández I; Gonzalez C
7
8
-
2017
The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation
Carbonell A; Pérez-Montero S; Climent-Cantó P; Reina O; Azorín F
21
11
3178 -
3189
2017
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
Martin-Malpartida P; Batet M; Kaczmarska Z; Freier R; Gomes T; Aragón E; Zou Y; Wang Q; Xi Q; Ruiz L; Vea A; Márquez J; Massagué J; Macias M
8
1
2070 -
2017
Reduced mutation rate in exons due to differential mismatch repair
Frigola J; Sabarinathan R; Mularoni L; Muinõs F; Gonzalez-Perez A; López-Bigas N
49
12
1684 -
1692
2017
Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona
Feiner-Gracia N; Beck M; Pujals S; Tosi S; Mandal T; Buske C; Linden M; Albertazzi L
13
41
-
2017
Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial
Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR
18
11
1543 -
1552
2017
Cancer stem cells revisited
Batlle E; Clevers H
23
10
1124 -
1134
2017
Differential requirements for Tousled-like kinases 1 and 2 in mammalian development
Segura-Bayona S; Knobel PA; Gonzalez-Buron H; Youssef SA; Peña-Blanco A; Coyaud E; Lopez-Rovira T; Rein K; Palenzuela L; Colombelli J; Forrow S; Raught B; Groth A; De Bruin A; Stracker TH
24
11
1872 -
1885
2017
Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing
Barrio L; Milán M
6
e22013
-
2017
Feedback amplification loop drives malignant growth in epithelial tissues
Muzzopappa M; Murcia L; Milán M
114
35
E7291 -
E7300
2017
Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
Bayona-Feliu A; Casas-Lamesa A; Reina O; Bernués J; Azorín F
8
1
283 -
2017
Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs
Weill L; Belloc E; Castellazzi CL; Méndez R
24
8
672 -
681
2017
Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes
Supek F; Lehner B
170
3
534 -
547.e23
2017
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment
Testoni G; Duran J; García-Rocha M; Vilaplana F; Serrano A; Sebastián D; López-Soldado I; Sullivan M; Slebe F; Vilaseca M; Muñoz-Cánoves P; Guinovart J
26
1
256 -
266.e4
2017
A genome editing approach to study cancer stem cells in human tumors
Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E
9
7
869 -
879
2017
Quantification of pathway cross-talk reveals novel synergistic drug combinations for breast cancer
Jaeger S; Igea A; Arroyo R; Alcalde V; Canovas B; Orozco M; Nebreda A; Aloy P
77
2
459 -
469
2017
A Drosophila model of myeloproliferative neoplasm reveals a feedforward loop in the JAK pathway mediated by p38 MAPK signalling
Terriente-Félix A; Pérez L; Bray S; Nebreda A; Milán M
10
4
399 -
407
2017
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E
20
6
801 -
816.e7
2017
JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
Recasens-Alvarez C; Ferreira A; Milán M
8
13815
13815 -
2017
Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance
Pluta, Radoslaw; Boer, D Roeland; Lorenzo-Diaz, Fabian; Russi, Silvia; Gomez, Hansel; Fernandez-Lopez, Cris; Perez-Luque, Rosa; Orozco, Modesto; Espinosa, Manuel; Coll, Miquel
114
32
E6526 -
E6535
2017
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M
25
6
1390 -
1399
2017
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul
19
2
94 -
105
2017
Targeting metastasis-initiating cells through the fatty acid receptor CD36.
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA
541
7635
41-45 -
+
2017
A p53-dependent response limits the viability of mammalian haploid cells
Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.
114
9367 -
9372
2017
TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells
Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O
429
2780 -
2789
2017
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R
7
11199
11199 -
2016
Epigenetic control of adult stem cell function
Avgustinova A; Benitah S
17
10
643 -
658
2016
The landscape of microbial phenotypic traits and associated genes
Brbi? M; Piškorec M; Vidulin V; Kriško A; Šmuc T; Supek F
44
21
10074 -
10090
2016
Small Details Matter: The 2′-Hydroxyl as a Conformational Switch in RNA
Darré L; Ivani I; Dans P; Gómez H; Hospital A; Orozco M
138
50
16355 -
16363
2016
CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets
Guillén-Boixet J; Buzon V; Salvatella X; Méndez R
5
NOVEMBER2016
-
2016
Amino acid transport associated to cluster of differentiation 98 heavy chain (CD98HC) is at the cross-road of oxidative stress and amino acid availability
De La Ballina LR; Cano-Crespo S; González-Muñoz E; Bial S; Estrach S; Cailleteau L; Tissot F; Daniel H; Zorzano A; Ginsberg MH; Palacín M; Féral CC
291
18
9700 -
9711
2016
The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells
Gubern A; Joaquin M; Marquès M; Maseres P; Garcia-Garcia J; Amat R; González-Nuñez D; Oliva B; Real F; de Nadal E; Posas F
64
1
25 -
36
2016
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
Becker D; Kaczmarska Z; Arkona C; Schulz R; Tauber C; Wolber G; Hilgenfeld R; Coll M; Rademann J
7
12761
12761 -
2016
The rules and impact of nonsense-mediated mRNA decay in human cancers
Lindeboom R; Supek F; Lehner B
48
10
1112 -
1118
2016
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez MI; Serrano AL; Palacín M; Zorzano A
35
15
1677 -
1693
2016
Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
Izquierdo-Serra M; Bautista-Barrufet A; Trapero A; Garrido-Charles A; Diaz-Tahoces A; Camarero N; Pittolo S; Valbuena S; Perez-Jimenez A; Gay M; Garcia-Moll A; Rodriguez-Escrich C; Lerma J; De La Villa P; Fernandez E; Pericas M; Llebaria A; Gorostiza P
7
12221
12221 -
2016
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
Sánchez-Huertas C; Freixo F; Viais R; Lacasa C; Soriano E; Lüders J
7
12187
12187 -
2016
Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X
110
11
2361 -
2366
2016
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Sabarinathan R; Mularoni L; Deu-Pons J; Gonzalez-Perez A; Lopez-Bigas N
532
7598
264 -
267
2016
Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea
Djabrayan N; Casanova J
12
3
e1005909 -
2016