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Research publications

Iridium-Catalyzed Isomerization of N-Sulfonyl Aziridines to Allyl Amines
Cabré A, Sciortino G, Ujaque G, Verdaguer X, Lledós A, Riera A
20
18
5747 -
5751
2018
A versatile drug delivery system targeting senescent cells
Muñoz-Espín D; Rovira M; Galiana I; Giménez C; Lozano-Torres B; Paez-Ribes M; Llanos S; Chaib S; Muñoz-Martín M; Ucero AC; Garaulet G; Mulero F; Dann SG; VanArsdale T; Shields DJ; Bernardos A; Murguía JR; Martínez-Máñez R; Serrano M
10
9
-
2018
Total Synthesis of ( R)-Sarkomycin Methyl Ester via Regioselective Intermolecular Pauson-Khand Reaction and Iridium-Catalyzed Asymmetric Isomerization.
Cabré A, Khaizourane H, Garçon M, Verdaguer X, Riera A
20
13
3953 -
3957
2018
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Parras A; Anta H; Santos-Galindo M; Swarup V; Elorza A; Nieto-González J; Picó S; Hernández I; Díaz-Hernández J; Belloc E; Rodolosse A; Parikshak N; Peñagarikano O; Fernández-Chacón R; Irimia M; Navarro P; Geschwind D; Méndez R; Lucas J
560
7719
441 -
446
2018
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.
Tauriello DVF, Palomo-Ponce S, Stork D, Berenguer-Llergo A, Badia-Ramentol J, Iglesias M, Sevillano M, Ibiza S, Cañellas A, Hernando-Momblona X, Byrom D, Matarin JA, Calon A, Rivas EI, Nebreda AR, Riera A, Attolini CS, Batlle E
554
7693
538 -
543
2018
NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization
Freixo, Francisco; Delgado, Paula Martinez; Manso, Yasmina; Sanchez-Huertas, Carlos; Lacasa, Cristina; Soriano, Eduardo; Roig, Joan; Lueders, Jens
9
2330
2330 -
2018
Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
Cánovas B; Igea A; Sartori A; Gomis R; Paull T; Isoda M; Pérez-Montoyo H; Serra V; González-Suárez E; Stracker T; Nebreda A
33
6
1094 -
1110.e8
2018
The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity
Lynch, Cian J; Bernad, Raquel; Calvo, Isabel; Nobrega-Pereira, Sandrina; Ruiz, Sergio; Ibarz, Nuria; Martinez-Val, Ana; Grana-Castro, Osvaldo; Gomez-Lopez, Gonzalo; Andres-Leon, Eduardo; Angarica, Vladimir Espinosa; del Sol, Antonio; Ortega, Sagrario; Fernandez-Capetillo, Oscar; Rojo, Enrique; Munoz, Javier; Serrano, Manuel
22
2
396 -
410
2018
Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids.
Vilches C, Boiadjieva-Knöpfel E, Bodoy S, Camargo S, López de Heredia M, Prat E, Ormazabal A, Artuch R, Zorzano A, Verrey F, Nunes V, Palacín M
29
6
1624 -
1635
2018
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
Tamborero D; Rubio-Perez C; Deu-Pons J; Schroeder M; Vivancos A; Rovira A; Tusquets I; Albanell J; Rodon J; Tabernero J; de Torres C; Dienstmann R; Gonzalez-Perez A; Lopez-Bigas N
10
1
467 -
2018
Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in Age-Related Hearing Loss.
Espino Guarch M, Font-Llitjós M, Murillo-Cuesta S, Errasti-Murugarren E, Celaya AM, Girotto G, Vuckovic D, Mezzavilla M, Vilches C, Bodoy S, Sahún I, González L, Prat E, Zorzano A, Dierssen M, Varela-Nieto I, Gasparini P, Palacín M, Nunes V
7
e31511
-
2018
MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+breast cancer
Gawrzak S; Rinaldi L; Gregorio S; Arenas EJ; Salvador F; Urosevic J; Figueras-Puig C; Rojo F; Del Barco Barrantes I; Cejalvo JM; Palafox M; Guiu M; Berenguer-Llergo A; Symeonidi A; Bellmunt A; Kalafatovic D; Arnal-Estapé A; Fernández E; Müllauer B; Groeneveld R; Slobodnyuk K; Stephan-Otto Attolini C; Saura C; Arribas J; Cortes J; Rovira A; Muñoz M; Lluch A; Serra V; Albanell J; Prat A; Nebreda AR; Benitah SA; Gomis RR
20
2
211 -
221
2018
ERF deletion rescues RAS deficiency in mouse ES cells
Mayor-Ruiz C., Olbrich T., Drosten M., Lecona E., Vega-Sendino M., Ortega S., Dominguez O., Barbacid M., Ruiz S. & Fernandez-Capetillo O
32
568 -
576
2018
Clonal analysis of lineage fate in native haematopoiesis
Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo
2018
The transcriptome of human oocytes is related to age and ovarian reserve
Barragán M; Pons J; Ferrer-Vaquer A; Cornet-Bartolomé D; Schweitzer A; Hubbard J; Auer H; Rodolosse A; Vassena R
23
8
535 -
548
2017
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas G; Peixoto FO; Perdiguero E; Jardí M; Ruiz-Bonilla V; Datta D; Symeonidi A; Castellanos A; Welz PS; Caballero JM; Sassone-Corsi P; Muñoz-Cánoves P; Benitah SA
170
4
678 -
692.e20
2017
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging
Sato S; Solanas G; Peixoto FO; Bee L; Symeonidi A; Schmidt MS; Brenner C; Masri S; Benitah SA; Sassone-Corsi P
170
4
664 -
677.e11
2017
The dynamic assembly of distinct RNA polymerase i complexes modulates rDNA transcription
Torreira E; Louro J; Pazos I; González-Polo N; Gil-Carton D; Duran A; Tosi S; Gallego O; Calvo O; Fernández-Tornero C
6
e20832
-
2017
Tetraspanin 6: A pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Guix FX; Sannerud R; Berditchevski F; Arranz AM; Horré K; Snellinx A; Thathiah A; Saido T; Saito T; Rajesh S; Overduin M; Kumar-Singh S; Radaelli E; Corthout N; Colombelli J; Tosi S; Munck S; Salas IH; Annaert W; De Strooper B
12
1
25 -
2017
Structure of the homodimeric androgen receptor ligand-binding domain
Nadal M; Prekovic S; Gallastegui N; Helsen C; Abella M; Zielinska K; Gay M; Vilaseca M; Taulès M; Houtsmuller A; Van Royen M; Claessens F; Fuentes-Prior P; Estébanez-Perpiñá E
8
14388
14388 -
2017
Polarized cortical tension drives zebrafish epiboly movements
Hernández-Vega A; Marsal M; Pouille P; Tosi S; Colombelli J; Luque T; Navajas D; Pagonabarraga I; Martín-Blanco E
36
1
25 -
41
2017
An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth
Rossi F; Molnar C; Hashiyama K; Heinen J; Pampalona J; Llamazares S; Reina J; Hashiyama T; Rai M; Pollarolo G; Fernández-Hernández I; Gonzalez C
7
8
-
2017
The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation
Carbonell A; Pérez-Montero S; Climent-Cantó P; Reina O; Azorín F
21
11
3178 -
3189
2017
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
Martin-Malpartida P; Batet M; Kaczmarska Z; Freier R; Gomes T; Aragón E; Zou Y; Wang Q; Xi Q; Ruiz L; Vea A; Márquez J; Massagué J; Macias M
8
1
2070 -
2017
Reduced mutation rate in exons due to differential mismatch repair
Frigola J; Sabarinathan R; Mularoni L; Muinõs F; Gonzalez-Perez A; López-Bigas N
49
12
1684 -
1692
2017
Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona
Feiner-Gracia N; Beck M; Pujals S; Tosi S; Mandal T; Buske C; Linden M; Albertazzi L
13
41
-
2017
Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial
Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR
18
11
1543 -
1552
2017
Cancer stem cells revisited
Batlle E; Clevers H
23
10
1124 -
1134
2017
Differential requirements for Tousled-like kinases 1 and 2 in mammalian development
Segura-Bayona S; Knobel PA; Gonzalez-Buron H; Youssef SA; Peña-Blanco A; Coyaud E; Lopez-Rovira T; Rein K; Palenzuela L; Colombelli J; Forrow S; Raught B; Groth A; De Bruin A; Stracker TH
24
11
1872 -
1885
2017
Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing
Barrio L; Milán M
6
e22013
-
2017
Feedback amplification loop drives malignant growth in epithelial tissues
Muzzopappa M; Murcia L; Milán M
114
35
E7291 -
E7300
2017
Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
Bayona-Feliu A; Casas-Lamesa A; Reina O; Bernués J; Azorín F
8
1
283 -
2017
Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs
Weill L; Belloc E; Castellazzi CL; Méndez R
24
8
672 -
681
2017
Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes
Supek F; Lehner B
170
3
534 -
547.e23
2017
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment
Testoni G; Duran J; García-Rocha M; Vilaplana F; Serrano A; Sebastián D; López-Soldado I; Sullivan M; Slebe F; Vilaseca M; Muñoz-Cánoves P; Guinovart J
26
1
256 -
266.e4
2017
A genome editing approach to study cancer stem cells in human tumors
Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E
9
7
869 -
879
2017
Quantification of pathway cross-talk reveals novel synergistic drug combinations for breast cancer
Jaeger S; Igea A; Arroyo R; Alcalde V; Canovas B; Orozco M; Nebreda A; Aloy P
77
2
459 -
469
2017
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E
20
6
801 -
816.e7
2017
JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
Recasens-Alvarez C; Ferreira A; Milán M
8
13815
13815 -
2017
Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance
Pluta, Radoslaw; Boer, D Roeland; Lorenzo-Diaz, Fabian; Russi, Silvia; Gomez, Hansel; Fernandez-Lopez, Cris; Perez-Luque, Rosa; Orozco, Modesto; Espinosa, Manuel; Coll, Miquel
114
32
E6526 -
E6535
2017
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M
25
6
1390 -
1399
2017
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul
19
2
94 -
105
2017
Targeting metastasis-initiating cells through the fatty acid receptor CD36.
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA
541
7635
41-45 -
+
2017
A p53-dependent response limits the viability of mammalian haploid cells
Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.
114
9367 -
9372
2017
TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells
Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O
429
2780 -
2789
2017
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R
7
11199
11199 -
2016
Epigenetic control of adult stem cell function
Avgustinova A; Benitah S
17
10
643 -
658
2016
The landscape of microbial phenotypic traits and associated genes
Brbi? M; Piškorec M; Vidulin V; Kriško A; Šmuc T; Supek F
44
21
10074 -
10090
2016