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Research

At the forefront of biomedicine

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Research publications

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial
Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR
18
11
1543 -
1552
2017
Cancer stem cells revisited
Batlle E; Clevers H
23
10
1124 -
1134
2017
Differential requirements for Tousled-like kinases 1 and 2 in mammalian development
Segura-Bayona S; Knobel PA; Gonzalez-Buron H; Youssef SA; Peña-Blanco A; Coyaud E; Lopez-Rovira T; Rein K; Palenzuela L; Colombelli J; Forrow S; Raught B; Groth A; De Bruin A; Stracker TH
24
11
1872 -
1885
2017
Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing
Barrio L; Milán M
6
e22013
-
2017
Feedback amplification loop drives malignant growth in epithelial tissues
Muzzopappa M; Murcia L; Milán M
114
35
E7291 -
E7300
2017
Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
Bayona-Feliu A; Casas-Lamesa A; Reina O; Bernués J; Azorín F
8
283
283 -
2017
Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs
Weill L; Belloc E; Castellazzi CL; Méndez R
24
8
672 -
+
2017
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment
Testoni G; Duran J; García-Rocha M; Vilaplana F; Serrano A; Sebastián D; López-Soldado I; Sullivan M; Slebe F; Vilaseca M; Muñoz-Cánoves P; Guinovart J
26
1
256 -
+
2017
A genome editing approach to study cancer stem cells in human tumors
Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E
9
7
869 -
879
2017
Quantification of pathway cross-talk reveals novel synergistic drug combinations for breast cancer
Jaeger S; Igea A; Arroyo R; Alcalde V; Canovas B; Orozco M; Nebreda A; Aloy P
77
2
459 -
469
2017
Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells
Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E
20
6
801 -
+
2017
JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling
Recasens-Alvarez C; Ferreira A; Milán M
8
13815
13815 -
2017
Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance
Pluta, Radoslaw; Boer, D Roeland; Lorenzo-Diaz, Fabian; Russi, Silvia; Gomez, Hansel; Fernandez-Lopez, Cris; Perez-Luque, Rosa; Orozco, Modesto; Espinosa, Manuel; Coll, Miquel
114
32
E6526 -
E6535
2017
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M
25
6
1390 -
1399
2017
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul
19
2
94 -
105
2017
Targeting metastasis-initiating cells through the fatty acid receptor CD36.
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA
541
7635
41 -
+
2017
A p53-dependent response limits the viability of mammalian haploid cells
Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.
114
9367 -
9372
2017
TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells
Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O
429
2780 -
2789
2017
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R
7
11199
11199 -
2016
Epigenetic control of adult stem cell function
Avgustinova A; Benitah S
17
10
643 -
658
2016
Small Details Matter: The 2′-Hydroxyl as a Conformational Switch in RNA
Darré L; Ivani I; Dans P; Gómez H; Hospital A; Orozco M
138
50
16355 -
16363
2016
CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets
Guillén-Boixet J; Buzon V; Salvatella X; Méndez R
5
e19298
-
2016
Amino acid transport associated to cluster of differentiation 98 heavy chain (CD98HC) is at the cross-road of oxidative stress and amino acid availability
De La Ballina LR; Cano-Crespo S; González-Muñoz E; Bial S; Estrach S; Cailleteau L; Tissot F; Daniel H; Zorzano A; Ginsberg MH; Palacín M; Féral CC
291
18
9700 -
9711
2016
The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells
Gubern A; Joaquin M; Marquès M; Maseres P; Garcia-Garcia J; Amat R; González-Nuñez D; Oliva B; Real F; de Nadal E; Posas F
64
1
25 -
36
2016
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
Becker D; Kaczmarska Z; Arkona C; Schulz R; Tauber C; Wolber G; Hilgenfeld R; Coll M; Rademann J
7
12761
12761 -
2016
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez MI; Serrano AL; Palacín M; Zorzano A
35
15
1677 -
1693
2016
Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
Izquierdo-Serra M; Bautista-Barrufet A; Trapero A; Garrido-Charles A; Diaz-Tahoces A; Camarero N; Pittolo S; Valbuena S; Perez-Jimenez A; Gay M; Garcia-Moll A; Rodriguez-Escrich C; Lerma J; De La Villa P; Fernandez E; Pericas M; Llebaria A; Gorostiza P
7
12221
12221 -
2016
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
Sánchez-Huertas C; Freixo F; Viais R; Lacasa C; Soriano E; Lüders J
7
12187
12187 -
2016
Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X
110
11
2361 -
2366
2016
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Sabarinathan R; Mularoni L; Deu-Pons J; Gonzalez-Perez A; Lopez-Bigas N
532
7598
264 -
267
2016
Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea
Djabrayan N; Casanova J
12
3
e1005909 -
2016
A feedback mechanism converts individual cell features into a supracellular ECM structure in drosophila trachea
Öztürk-Çolak A; Moussian B; Araújo SJ; Casanova J
5
FEBRUARY2016
-
2016
Multiscale simulation of DNA
Dans P; Walther J; Gómez H; Orozco M
37
29 -
45
2016
Developing Epithelia: What the Eye Cannot Grasp
Tosi, Sebastien; Milan, Marco
36
1
7 -
8
2016
Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis
Clemente-Ruiz, Marta; Murillo-Maldonado, Juan M; Benhra, Najate; Barrio, Lara; Perez, Lidia; Quiroga, Gonzalo; Nebreda, Angel R; Milan, Marco
36
3
290 -
302
2016
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis
Rinaldi, Lorenzo; Datta, Debayan; Serrat, Judit; Morey, Lluis; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Ignacio Pons, Jose; Matallanas, David; Von Kriegsheim, Alex; Di Croce, Luciano; Aznar Benitah, Salvador
19
4
491 -
501
2016
Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry
Pittis, Alexandros A; Gabaldon, Toni
531
7592
101 -
+
2016
Saturation of recognition elements blocks evolution of new tRNA identities
Saint-Leger, Adelaide; Bello, Carla; Dans, Pablo D; Gabriel Torres, Adrian; Maria Novoa, Eva; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A; Ribas de Pouplana, Lluis
2
4
e1501860 -
2016
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
Salomó E, Orgué S, Riera A, Verdaguer X
55
28
7988 -
7992
2016
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor
De Mol E, Fenwick RB, Phang CT, Buzón V, Szulc E, de la Fuente A, Escobedo A, García J, Bertoncini CW, Estébanez-Perpiñá E, McEwan IJ, Riera A, Salvatella X
11
9
2499 -
2505
2016
Parmbsc1: A refined force field for DNA simulations
Ivani I; Dans P; Noy A; Pérez A; Faustino I; Hospital A; Walther J; Andrio P; Goñi R; Balaceanu A; Portella G; Battistini F; Gelpí J; González C; Vendruscolo M; Laughton C; Harris S; Case D; Orozco M
13
1
55 -
+
2016
Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1
Nagamori S; Wiriyasermkul P; Guarch M; Okuyama H; Nakagomi S; Tadagaki K; Nishinaka Y; Bodoy S; Takafuji K; Okuda S; Kurokawa J; Ohgaki R; Nunes V; Palacín M; Kanai Y
113
3
775 -
780
2016
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y, Nebreda AR
7
11084
11084 -
2016
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R
150
4
982 -
+
2016
BRD4 connects super enhancer remodeling to senescence immune surveillance
Tasdemir N*, Banito B*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CV, Lowe SW. *Co-first authors
2016
A genome- wide CRISPR screen identifies Cdc25A as a determinant of sensitivity to ATR inhibitors
Ruiz S. (#), Mayor-Ruiz C. (#), Lafarga V., Murga M., Vega-Sendino M., Ortega S., Fernandez-Capetillo O. ( # Equal contribution)
62
307 -
313
2016
Designing alternative splicing RNA-seq studies. Beyond generic guidelines
Stephan-Otto Attolini C; Peña V; Rossell D
31
22
3631 -
3637
2015
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models
Huang Y; Skwarek-Maruszewska A; Horré K; Vandewyer E; Wolfs L; Snellinx A; Saito T; Radaelli E; Corthout N; Colombelli J; Lo AC; Van Aerschot L; Callaerts-Vegh Z; Trabzuni D; Bossers K; Verhaagen J; Ryten M; Munck S; D'Hooge R; Swaab DF; Hardy J; Saido TC; De Strooper B; Thathiah A
7
309
309ra164 -
2015