Research publications

Title

Year

Research Group

Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity

Finley LWS*, Vardhana SA*, Carey BW*, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, et al, [corr author] Thompson CB. (*equal contribution)

2018

Arid1a restrains Kras-dependent changes in acinar cell identity

Livshits D, Alonso-Curbelo D, Morris JP4th, Koche R, Saborowski M, Wilkinson JE, Lowe SW

2018

ERF deletion rescues RAS deficiency in mouse ES cells

Mayor-Ruiz C., Olbrich T., Drosten M., Lecona E., Vega-Sendino M., Ortega S., Dominguez O., Barbacid M., Ruiz S. & Fernandez-Capetillo O

568 -

576

2018

Clonal analysis of lineage fate in native haematopoiesis

Alejo E Rodriguez-Fraticelli, Samuel L Wolock, Caleb S Weinreb, Riccardo Panero, Sachin H Patel, Maja Jankovic, Jianlong Sun, Raffaele A Calogero, Allon M Klein, Fernando D Camargo

2018

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, Navarro P, Geschwind DH, Méndez R*, Lucas JJ*. (* co-corresponding authors).

560

7719

441 -

2018

The transcriptome of human oocytes is related to age and ovarian reserve

Barragán M; Pons J; Ferrer-Vaquer A; Cornet-Bartolomé D; Schweitzer A; Hubbard J; Auer H; Rodolosse A; Vassena R

535 -

548

2017

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Solanas G; Peixoto FO; Perdiguero E; Jardí M; Ruiz-Bonilla V; Datta D; Symeonidi A; Castellanos A; Welz PS; Caballero JM; Sassone-Corsi P; Muñoz-Cánoves P; Benitah SA

170

678 -

2017

Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging

Sato S; Solanas G; Peixoto FO; Bee L; Symeonidi A; Schmidt MS; Brenner C; Masri S; Benitah SA; Sassone-Corsi P

170

664 -

2017

Loss of dnmt3a and dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-g

Rinaldi L; Avgustinova A; Martín M; Datta D; Solanas G; Neus P; Benitah SA

e21697

e21697 -

2017

The dynamic assembly of distinct RNA polymerase i complexes modulates rDNA transcription

Torreira E; Louro J; Pazos I; González-Polo N; Gil-Carton D; Duran A; Tosi S; Gallego O; Calvo O; Fernández-Tornero C

e20832

e20832 -

2017

Tetraspanin 6: A pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Guix FX; Sannerud R; Berditchevski F; Arranz AM; Horré K; Snellinx A; Thathiah A; Saido T; Saito T; Rajesh S; Overduin M; Kumar-Singh S; Radaelli E; Corthout N; Colombelli J; Tosi S; Munck S; Salas IH; Annaert W; De Strooper B

25 -

2017

Structure of the homodimeric androgen receptor ligand-binding domain

Nadal M; Prekovic S; Gallastegui N; Helsen C; Abella M; Zielinska K; Gay M; Vilaseca M; Taulès M; Houtsmuller A; Van Royen M; Claessens F; Fuentes-Prior P; Estébanez-Perpiñá E

14388

14388 -

2017

Polarized cortical tension drives zebrafish epiboly movements

Hernández-Vega A; Marsal M; Pouille P; Tosi S; Colombelli J; Luque T; Navajas D; Pagonabarraga I; Martín-Blanco E

25 -

2017

An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth

Rossi F; Molnar C; Hashiyama K; Heinen J; Pampalona J; Llamazares S; Reina J; Hashiyama T; Rai M; Pollarolo G; Fernández-Hernández I; Gonzalez C

170156 -

2017

The Germline Linker Histone dBigH1 and the Translational Regulator Bam Form a Repressor Loop Essential for Male Germ Stem Cell Differentiation

Carbonell A; Pérez-Montero S; Climent-Cantó P; Reina O; Azorín F

3178 -

3189

2017

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

Martin-Malpartida P; Batet M; Kaczmarska Z; Freier R; Gomes T; Aragón E; Zou Y; Wang Q; Xi Q; Ruiz L; Vea A; Márquez J; Massagué J; Macias M

2070

2070 -

2017

Reduced mutation rate in exons due to differential mismatch repair

Frigola J; Sabarinathan R; Mularoni L; Muinõs F; Gonzalez-Perez A; López-Bigas N

1684 -

2017

Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona

Feiner-Gracia N; Beck M; Pujals S; Tosi S; Mandal T; Buske C; Linden M; Albertazzi L

1701631 -

1701631

2017

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial

Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR

1543 -

1552

2017

Cancer stem cells revisited

Batlle E; Clevers H

1124 -

1134

2017

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development

Segura-Bayona S; Knobel PA; Gonzalez-Buron H; Youssef SA; Peña-Blanco A; Coyaud E; Lopez-Rovira T; Rein K; Palenzuela L; Colombelli J; Forrow S; Raught B; Groth A; De Bruin A; Stracker TH

1872 -

1885

2017

Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing

Barrio L; Milán M

e22013

e22013 -

2017

Feedback amplification loop drives malignant growth in epithelial tissues

Muzzopappa M; Murcia L; Milán M

114

E7291 -

E7300

2017

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

Bayona-Feliu A; Casas-Lamesa A; Reina O; Bernués J; Azorín F

283

283 -

2017

Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs

Weill L; Belloc E; Castellazzi CL; Méndez R

672 -

2017

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

Testoni G; Duran J; García-Rocha M; Vilaplana F; Serrano A; Sebastián D; López-Soldado I; Sullivan M; Slebe F; Vilaseca M; Muñoz-Cánoves P; Guinovart J

256 -

2017

A genome editing approach to study cancer stem cells in human tumors

Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E

869 -

879

2017

Quantification of pathway cross-talk reveals novel synergistic drug combinations for breast cancer

Jaeger S; Igea A; Arroyo R; Alcalde V; Canovas B; Orozco M; Nebreda A; Aloy P

459 -

469

2017

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E

801 -

2017

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

Recasens-Alvarez C; Ferreira A; Milán M

13815

13815 -

2017

Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Pluta, Radoslaw; Boer, D Roeland; Lorenzo-Diaz, Fabian; Russi, Silvia; Gomez, Hansel; Fernandez-Lopez, Cris; Perez-Luque, Rosa; Orozco, Modesto; Espinosa, Manuel; Coll, Miquel

114

E6526 -

E6535

2017

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M

1390 -

1399

2017

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul

94 -

105

2017

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA

541

7635

41 -

2017

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.

114

9367 -

9372

2017

TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells

Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O

429

2780 -

2789

2017

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R

11199

11199 -

2016

Epigenetic control of adult stem cell function

Avgustinova A; Benitah S

643 -

658

2016

Small Details Matter: The 2′-Hydroxyl as a Conformational Switch in RNA

Darré L; Ivani I; Dans P; Gómez H; Hospital A; Orozco M

138

16355 -

16363

2016

CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

Guillén-Boixet J; Buzon V; Salvatella X; Méndez R

e19298

e19298 -

2016

Amino acid transport associated to cluster of differentiation 98 heavy chain (CD98HC) is at the cross-road of oxidative stress and amino acid availability

De La Ballina LR; Cano-Crespo S; González-Muñoz E; Bial S; Estrach S; Cailleteau L; Tissot F; Daniel H; Zorzano A; Ginsberg MH; Palacín M; Féral CC

291

9700 -

9711

2016

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

Gubern A; Joaquin M; Marquès M; Maseres P; Garcia-Garcia J; Amat R; González-Nuñez D; Oliva B; Real F; de Nadal E; Posas F

25 -

2016

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Becker D; Kaczmarska Z; Arkona C; Schulz R; Tauber C; Wolber G; Hilgenfeld R; Coll M; Rademann J

12761

12761 -

2016

Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez MI; Serrano AL; Palacín M; Zorzano A

1677 -

1693

2016

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Izquierdo-Serra M; Bautista-Barrufet A; Trapero A; Garrido-Charles A; Diaz-Tahoces A; Camarero N; Pittolo S; Valbuena S; Perez-Jimenez A; Gay M; Garcia-Moll A; Rodriguez-Escrich C; Lerma J; De La Villa P; Fernandez E; Pericas M; Llebaria A; Gorostiza P

12221

12221 -

2016

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

Sánchez-Huertas C; Freixo F; Viais R; Lacasa C; Soriano E; Lüders J

12187

12187 -

2016

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X

110

2361 -