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Research

At the forefront of biomedicine

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Research publications

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination
Marjanovi? M; Sánchez-Huertas C; Terré B; Gómez R; Scheel J; Pacheco S; Knobel P; Martínez-Marchal A; Aivio S; Palenzuela L; Wolfrum U; McKinnon P; Suja J; Roig I; Costanzo V; Lüders J; Stracker T
6
7676
7676 -
2015
Hyperactivated endolysosomal trafficking in melanoma
Alonso-Curbelo D, Soengas MS
2015
RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development
Alonso-Curbelo D, Osterloh L, Cañón E, Calvo TG, Martínez-Herranz R, Karras P, Martínez S, et al, [corr. author] Soengas MS.
2015
Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
Urosevic, Jelena; Garcia-Albeniz, Xabier; Planet, Evarist; Real, Sebastian; Cespedes, Maria Virtudes; Guiu, Marc; Fernandez, Esther; Bellmunt, Anna; Gawrzak, Sylwia; Pavlovic, Milica; Mangues, Ramon; Dolado, Ignacio; Barriga, Francisco M; Nadal, Cristina; Kemeny, Nancy; Batlle, Eduard; Nebreda, Angel R; Gomis, Roger R
16
7
685 -
694
2014
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
Whissell, Gavin; Montagni, Elisa; Martinelli, Paola; Hernando-Momblona, Xavier; Sevillano, Marta; Jung, Peter; Cortina, Carme; Calon, Alexandre; Abuli, Anna; Castells, Antoni; Castellvi-Bel, Sergi; Nacht, Ana Silvina; Sancho, Elena; Stephan-Otto Attolini, Camille; Vicent, Guillermo P; Real, Francisco X; Batlle, Eduard
16
7
695 -
707
2014
Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia
Saez, Isabel; Duran, Jordi; Sinadinos, Christopher; Beltran, Antoni; Yanes, Oscar; Tevy, Maria F; Martinez-Pons, Carlos; Milan, Marco; Guinovart, Joan J
34
6
945 -
955
2014
Converging axons collectively initiate and maintain synaptic selectivity in a constantly remodeling sensory organ
Pujol-Martí J; Faucherre A; Aziz-Bose R; Asgharsharghi A; Colombelli J; Trapani J; López-Schier H
24
24
2968 -
2974
2014
Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry
Slamnoiu S; Vlad C; Stumbaum M; Moise A; Lindner K; Engel N; Vilanova M; Diaz M; Karreman C; Leist M; Ciossek T; Hengerer B; Vilaseca M; Przybylski M
25
8
1472 -
1481
2014
Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function
Cuartero S; Fresán U; Reina O; Planet E; Espinàs M
33
6
637 -
647
2014
Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements
Zhou R; Maisuradze G; Suñol D; Todorovski T; Macias M; Xiao Y; Scheraga H; Czaplewski C; Liwo A
111
51
18243 -
18248
2014
The dynamics of microtubule minus ends in the human mitotic spindle
Lecland N; Lüders J
16
8
770 -
778
2014
Forces driving epithelial wound healing
Brugués A; Anon E; Conte V; Veldhuis JH; Gupta M; Colombelli J; Muñoz JJ; Brodland GW; Ladoux B; Trepat X
10
9
683 -
690
2014
A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Afroz T; Skrisovska L; Belloc E; Guillén-Boixet J; Méndez R; Allain F
28
13
1498 -
1514
2014
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation
Morales M; Arenas EJ; Urosevic J; Guiu M; Fernández E; Planet E; Fenwick RB; Fernández-Ruiz S; Salvatella X; Reverter D; Carracedo A; Massagué J; Gomis RR
6
7
865 -
881
2014
Correlated motions are a fundamental property of β-sheets
Fenwick R; Orellana L; Esteban-Martín S; Orozco M; Salvatella X
5
4070
4070 -
2014
Glycogen accumulation underlies neurodegeneration and autophagy impairment in lafora disease
Duran J; Gruart A; García-Rocha M; Delgado-García J; Guinovart J
23
12
3147 -
3156
2014
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes
Sala D; Ivanova S; Plana N; Ribas V; Duran J; Bach D; Turkseven S; Laville M; Vidal H; Karczewska-Kupczewska M; Kowalska I; Straczkowski M; Testar X; Palacín M; Sandri M; Serrano AL; Zorzano A
124
5
1914 -
1927
2014
Inferring gene function from evolutionary change in signatures of translation efficiency
Krisko A; Copic T; Gabaldón T; Lehner B; Supek F
15
3
R44 -
2014
Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival
Gupta J; delBarcoBarrantes I; Igea A; Sakellariou S; Pateras I; Gorgoulis V; Nebreda A
25
4
484 -
500
2014
Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
Rosell A; Meury M; A?varez-Marimon E; Costa M; Pe?ez-Cano L; Zorzano A; Ferna?dez-Recio J; Palaci? M; Fotiadis D
111
8
2966 -
2971
2014
Metastatic stem cells: Sources, niches, and vital pathways
Oskarsson T; Batlle E; Massagué J
14
3
306 -
321
2014
ChroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome
Font-Burgada J; Reina O; Rossell D; Azorín F
42
4
2126 -
2137
2014
Control of Cdc28 CDK1 by a Stress-Induced lncRNA
Nadal-Ribelles M; Solé C; Xu Z; Steinmetz LM; deNadal E; Posas F
53
4
549 -
561
2014
Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of at base pairs and cross-linking of DNA duplexes
Boer D; Wu L; Lincoln P; Coll M
53
7
1949 -
1952
2014
Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors
Boer D; Freire-Rios A; Van Den Berg W; Saaki T; Manfield I; Kepinski S; López-Vidrieo I; Franco-Zorrilla J; De Vries S; Solano R; Weijers D; Coll M
156
3
577 -
589
2014
Specification of leading and trailing cell features during collective migration in the Drosophila trachea
Lebreton G; Casanova J
127
2
465 -
474
2014
MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
Barrio, Lara; Dekanty, Andres; Milan, Marco
8
2
527 -
540
2014
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo
Maria Novoa, Eva; Camacho, Noelia; Tor, Anna; Wilkinson, Barrie; Moss, Steven; Marin-Garcia, Patricia; Azcarate, Isabel G; Bautista, Jose M; Mirando, Adam C; Francklyn, Christopher S; Varon, Sonia; Royo, Miriam; Cortes, Alfred; Ribas de Pouplana, Lluis
111
51
E5508 -
E5517
2014
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway
Alonso-Curbelo D, Riveiro-Falkenbach E, Pérez-Guijarro E, Cifdaloz M, Karras P, Osterloh L, Megías D, Cañón E, et al, [corr. author] Soengas MS.
2014
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
Winter G.E., Radic B. (#), Mayor-Ruiz C. (#), Blomen V.A., Trefzer C., Kandasamy R.K., Huber K.V.M., Gridling M., Chen D., Klampfl T., Kralovics R., Kubicek S., Fernandez-Capetillo O., Brummelkamp T.R., Superti-Furga G. (# Equal contribution)
10
768 -
773
2014
Erratum: Applications and future of ion mobility mass spectrometry in structural biology (New Journal of Chemistry (2013) 37 (1283-1289) DOI:10.1039/C3NJ41051J)
Branowska D; Chaciak B; Siuchta O; Olender E; Ledwon P; Lapkowski M; Poronik E; Wysocki W; Karczmarzyk Z; Skorka L; Filapek M; Krompiec S; Urbanczyk-Lipkowska Z; Kalicki P; Aresu E; Fioravanti S; Pellacani L; Sciubba F; Trulli L; López A; Tarragó T; Vilaseca M; Giralt E; Saßmannshausen J; Klett J; Kennedy AR; Parkinson JA; Armstrong D
37
12
4250 -
2013
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK
Pereira L; Igea A; Canovas B; Dolado I; Nebreda A
5
11
1759 -
1774
2013
Multi-phosphorylation of the intrinsically disordered unique domain of c-src studied by in-cell and real-time NMR spectroscopy
Amata I; Maffei M; Igea A; Gay M; Vilaseca M; Nebreda A; Pons M
14
14
1820 -
1827
2013
Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies
Guitart T; Picchioni D; Piñeyro D; Ribas De Pouplana L
41
13
6595 -
6608
2013
On the origin of the selectivity of plasmidic H-NS towards horizontally acquired DNA: Linking H-NS oligomerization and cooperative DNA binding
Fernández-De-Alba C; Berrow NS; Garcia-Castellanos R; García J; Pons M
425
13
2347 -
2358
2013
Applications and future of ion mobility mass spectrometry in structural biology
López A; Tarragó T; Vilaseca M; Giralt E
37
5
1283 -
1289
2013
Drosophila melanogaster: A model and a tool to investigate malignancy and identify new therapeutics
Gonzalez C
13
3
172 -
183
2013
Bantam miRNA promotes systemic growth by connecting insulin signaling and ecdysone production
Boulan L; Martín D; Milán M
23
6
473 -
478
2013
SnapShot: P38 MAPK substrates
Trempolec N; Dave-Coll N; Nebreda A
152
4
924 -
924.e1
2013
Characterization of superoxide dismutase 1 (SOD-1) by electrospray ionization-ion mobility mass spectrometry
Borges-Alvarez M; Benavente F; Vilaseca M; Barbosa J; Sanz-Nebot V
48
1
60 -
67
2013
Coordinated control of replication and transcription by a SAPK protects genomic integrity
Duch, Alba; Felipe-Abrio, Irene; Barroso, Sonia; Yaakov, Gilad; Garcia-Rubio, Maria; Aguilera, Andres; de Nadal, Eulalia; Posas, Francesc
493
7430
116 -
119
2013
Centrobin controls mother-daughter centriole asymmetry in Drosophila neuroblasts
Januschke, J; Reina, J; Llamazares, S; Bertran, T; Rossi, F; Roig, J; Gonzalez, C
15
3
241 -
248
2013
CPEB1 coordinates alternative 3''-UTR formation with translational regulation
Bava, Felice-Alessio; Eliscovich, Carolina; Ferreira, Pedro G; Minana, Belen; Ben-Dov, Claudia; Guigo, Roderic; Valcarcel, Juan; Mendez, Raul
495
7439
121 -
125
2013
Force communication in multicellular tissues addressed by laser nanosurgery
Colombelli, Julien; Solon, Jerome
352
1
133 -
147
2013
Fabrication of hierarchical micro-nanotopographies for cell attachment studies
Lopez-Bosque, M J; Tejeda-Montes, E; Cazorla, M; Linacero, J; Atienza, Y; Smith, K H; Llado, A; Colombelli, J; Engel, E; Mata, A
24
25
255305 -
255305
2013
Light-regulated stapled peptides to inhibit protein-protein interactions involved mediated endocytosis
Nevola, Laura; Martin-Quiros, Andres; Eckelt, Kay; Camarero, Nuria; Tosi, Sebastien; Llobet, Artur; Giralt, Ernest; Gorostiza, Pau
52
30
7704 -
7708
2013
The SLC3 and SLC7 families of amino acid transporters
Fotiadis D; Kanai Y; Palacín M
34
2-3
139 -
158
2013
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
Munoz, Juan Pablo; Ivanova, Saska; Sanchez-Wandelmer, Jana; Martinez-Cristobal, Paula; Noguera, Eduard; Sancho, Ana; Diaz-Ramos, Angels; Hernandez-Alvarez, Maria Isabel; Sebastian, David; Mauvezin, Caroline; Palacin, Manuel; Zorzano, Antonio
32
17
2348 -
2361
2013