Resistance to antibiotics

3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon

3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon


The radio programme of RNE Laboratorio de Jal has referred to the study of Miquel Coll’s group on the resistance of Staphylococcus aureus to antibiotics. This lethal bacterium has a mechanism by which antibiotic resistance genes are transferred.

Thanks to the resolution of a three-dimensional structure of the complex formed by relaxase with a fragment of the plasmid DNA, the researchers have identified an amino acid as a pivotal element of the transfer.

Link to RNE