Resistance to antibiotics

<p>3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon</p>

The radio programme of RNE Laboratorio de Jal has referred to the study of Miquel Coll’s group on the resistance of Staphylococcus aureus to antibiotics. This lethal bacterium has a mechanism by which antibiotic resistance genes are transferred.

Thanks to the resolution of a three-dimensional structure of the complex formed by relaxase with a fragment of the plasmid DNA, the researchers have identified an amino acid as a pivotal element of the transfer.

Link to RNE