Skip to main content
About IRB
Technology Transfer
Young Scientists
Research
Donate
Public engagement
Events
News
English
Català
Español
The medicine of the future
starts here
Toggle navigation
Alumni
Ernest Giralt
Research Group:
Design, synthesis and structure of peptides and proteins
Unit:
CHEMISTRY & MOLECULAR PHARMACOLOGY
Position:
Group Leader
Office:
EM01B21-22
Telephone:
+34 93 40 37125
Email:
ernest.giralt@irbbarcelona.org
Professor (Organic Chemistry Dept. - UB)
View research group
Meet our scientists Videos
Ernest Giralt: "The power of medicinal chemistry"
Selected group publications
Combating virulence of Gram-negative bacilli by OmpA inhibition
Vila-Farrés X, Parra-Millán R, Sánchez-Encinales V, Varese M, Ayerbe-Algaba R, Bayó N, Guardiola S, Pachón-Ibáñez ME, Kotev M, García J, Teixidó M, Vila J, Pachón J, Giralt E and Smani Y.
Sci Rep,
7
(1), 14683 (2017)
Jumping Hurdles: Peptides Able To Overcome Biological Barriers
Sánchez-Navarro M, Teixidó M and Giralt E.
Accounts Chem Res,
50
(8), 1847-1854 (2017)
Cytosolic delivery: Just passing through
Sánchez-Navarro M, Teixidó M and Giralt E.
Nat Chem,
9
(8), 727-728 (2017)
Blood-brain barrier peptide shuttles
Sánchez-Navarro M, Giralt E and Teixidó M.
Curr Opin Chem Biol,
38
134-140 (2017)
Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery
Oller-Salvia B, Sánchez-Navarro M, Giralt E and Teixidó M.
Chem Soc Rev,
45
(17), 4690-707 (2016)
MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery
Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.
Angew Chem Int Edit,
55
(2), 572-5 (2016)
Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles
Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M and Giralt E.
J Am Chem Soc,
137
(23), 7357-64 (2015)
Applying the retro-enantio approach to obtain a Peptide capable of overcoming the blood-brain barrier
Prades R, Oller-Salvia B, Schwarzmaier SM, Selva J, Moros M, Balbi M, Grazú V, de La Fuente JM, Egea G, Plesnila N, Teixidó M and Giralt E.
Angew Chem Int Edit,
54
(13), 3967-72 (2015)
Modulating protein-protein interactions: the potential of peptides
Nevola L and Giralt E.
Chem Commun,
51
3302-3315 (2015)
Absence of a stable secondary structure is not a limitation for photoswitchable inhibitors of β-arrestin/β-Adaptin 2 protein-protein interaction
Martín-Quirós A, Nevola L, Eckelt K, Madurga S, Gorostiza P and Giralt E.
Chem Biol,
22
(1), 31-7 (2015)
Delivering wasp venom for cancer therapy.
Moreno M, Zurita E, Giralt E.
J Control Release,
182
13-21 (2014)
Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease
Pujadas L, Rossi D, Andrés R, Teixeira CM, Serra-Vidal B, Parcerisas A, Maldonado R, Giralt E, Carulla N and Soriano E.
Nat Commun,
5
3443 (2014)
Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death
Serra-Vidal B, Pujadas L, Rossi D, Soriano E, Madurga S and Carulla N.
Acs Chem Biol,
9
(11), 2678-85 (2014)
From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog
Oller-Salvia B, Teixidó M and Giralt E.
Biopolymers,
100
(6), 675-86 (2013)
Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis
Nevola L, Martín-Quirós A, Eckelt K, Camarero N, Tosi S, Llobet A, Giralt E and Gorostiza P.
Angew Chem Int Edit,
52
(30), 7704-8 (2013)
Shuttle-Mediated Drug Delivery to the Brain
Malakoutikhah M, Teixidó M and Giralt E.
Angew Chem Int Edit,
50
7998-8014 (2011)
Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E)
Martín I, Teixidó M and Giralt E.
Chembiochem,
12
(6), 896-903 (2011)
Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties
Sánchez L, Madurga S, Pukala T, Vilaseca M, López-Iglesias C, Robinson CV, Giralt E and Carulla N.
J Am Chem Soc,
133
(17), 6505-8 (2011)
Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange
Carulla N, Zhou M, Giralt E, Robinson CV and Dobson CM.
Accounts Chem Res,
43
(8), 1072-9 (2010)
Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand
Gordo S, Martos V, Santos E, Menéndez M, Bo C, Giralt E and de Mendoza J.
P Natl Acad Sci Usa,
105
(43), 16426-31 (2008)
Redesign of protein domains using one-bead-one compound combinatorial chemistry
Pastor JJ, Granados G, Carulla N, Rabanal F and Giralt E
J Am Chem Soc,
129
14922-32 (2007)
Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
Pujals S, Fernandez-Carneado J, Kogan M, Martinez J, Cavelier F and Giralt E
J Am Chem Soc,
128
8479-83 (2006)