Ernest Giralt

    Research Group: 
    Design, synthesis and structure of peptides and proteins
    Unit: 
    CHEMISTRY & MOLECULAR PHARMACOLOGY
    Position: 
    Group Leader
    Office: 
    EM01B21-22
    Telephone: 
    +34 93 40 37125
    Email: 
    ernest.giralt@irbbarcelona.org

    Emeritus Professor (Inorganic and Organic Chemistry Dept. - UB)

     

    View research group

    Emeritus Professor (Inorganic and Organic Chemistry Dept.), University of Barcelona, Spain. Group leader of a Research Group in the Institute for Research in Biomedicine, in the Barcelona Science Park, where he is the Head of the Chemistry and Molecular Pharmacology Programme.

    His major interests lie in the field of peptide synthesis and structure determination, in particular using NMR to the study of complex molecular recognition processes, with emphasis on the design of specific ligands for interaction with protein surfaces, related to possible therapeutic uses. This includes studies concerning new drug delivery systems for the treatment of central nervous system pathologies.

    He has published around 450 papers, 20 patents, review articles and several books that have become a reference in the field of peptide chemistry. He is one of the founding members of the European Peptide Society. In 2011, he received the National Research Award from the Ministerio de Ciencia e Innovación (Spain).  He has been also awarded, among others, with the Premi Ciutat de Barcelona (2014), the Max Bergmann Medal (2014), and the Josef Rudinger Memorial Lecture Award (2014). by the European Peptide Society (EPS), the Novartis Chemistry Lectureship Award (2012), the Dimitrios Theodoropoulos Award (2010) and the Leonidas Zervas Award (1994).

    Meet our scientists Videos

    Ernest Giralt: "The power of medicinal chemistry"

    Selected group publications

    Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons.
    Pujols J, Peña-Díaz S, Lázaro DF, Peccati F, Pinheiro F, González D, Carija A, Navarro S, Conde-Giménez M, García J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Fleming Outeiro T, Dalfó E, Ventura.
    P Natl Acad Sci Usa, 115 10481-1048 (2018)
    Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
    Dıaz-Perlas C, Oller-Salvia B, Sanchez-Navarro M, Teixidó M, Giralt E.
    Chem Sci, (2018)
    Anti-EGF nanobodies block EGFR activation via two distinct molecular recognition mechanisms
    Guardiola S, Varese M, Sánchez-Navarro M, Vincke C, Teixido M, Garcia J, Muyldermans S and Giralt E.
    Angew Chem Int Edit, 15 13843-1384 (2018)
    Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics
    Guardiola S, Prades R, Mendieta L, Brouwer AJ, Streefkerk J, Nevola L, Tarragó T, Liskamp RMJ, Giralt E.
    Cell Chemical Biology, 25 1031-1037 (2018)
    Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics
    Guardiola S, Prades R, Mendieta L, Brouwer AJ, Streefkerk J, Nevola L, Tarragó T, Liskamp RMJ and Giralt E.
    Cell Chemical Biology, (2018)
    Combating virulence of Gram-negative bacilli by OmpA inhibition
    Vila-Farrés X, Parra-Millán R, Sánchez-Encinales V, Varese M, Ayerbe-Algaba R, Bayó N, Guardiola S, Pachón-Ibáñez ME, Kotev M, García J, Teixidó M, Vila J, Pachón J, Giralt E and Smani Y.
    Sci Rep, 7 (1), 14683 (2017)
    Jumping Hurdles: Peptides Able To Overcome Biological Barriers
    Sánchez-Navarro M, Teixidó M and Giralt E.
    Accounts Chem Res, 50 (8), 1847-1854 (2017)
    Cytosolic delivery: Just passing through
    Sánchez-Navarro M, Teixidó M and Giralt E.
    Nat Chem, 9 (8), 727-728 (2017)
    Blood-brain barrier peptide shuttles
    Sánchez-Navarro M, Giralt E and Teixidó M.
    Curr Opin Chem Biol, 38 134-140 (2017)
    Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery
    Oller-Salvia B, Sánchez-Navarro M, Giralt E and Teixidó M.
    Chem Soc Rev, 45 (17), 4690-707 (2016)
    MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery
    Oller-Salvia B, Sánchez-Navarro M, Ciudad S, Guiu M, Arranz-Gibert P, Garcia C, Gomis RR, Cecchelli R, García J, Giralt E and Teixidó M.
    Angew Chem Int Edit, 55 (2), 572-5 (2016)
    Lipid bilayer crossing--the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier shuttles
    Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M and Giralt E.
    J Am Chem Soc, 137 (23), 7357-64 (2015)
    Applying the retro-enantio approach to obtain a Peptide capable of overcoming the blood-brain barrier
    Prades R, Oller-Salvia B, Schwarzmaier SM, Selva J, Moros M, Balbi M, Grazú V, de La Fuente JM, Egea G, Plesnila N, Teixidó M and Giralt E.
    Angew Chem Int Edit, 54 (13), 3967-72 (2015)
    Modulating protein-protein interactions: the potential of peptides
    Nevola L and Giralt E.
    Chem Commun, 51 3302-3315 (2015)
    Absence of a stable secondary structure is not a limitation for photoswitchable inhibitors of β-arrestin/β-Adaptin 2 protein-protein interaction
    Martín-Quirós A, Nevola L, Eckelt K, Madurga S, Gorostiza P and Giralt E.
    Chem Biol, 22 (1), 31-7 (2015)
    Delivering wasp venom for cancer therapy.
    Moreno M, Zurita E, Giralt E.
    J Control Release, 182 13-21 (2014)
    Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer's disease
    Pujadas L, Rossi D, Andrés R, Teixeira CM, Serra-Vidal B, Parcerisas A, Maldonado R, Giralt E, Carulla N and Soriano E.
    Nat Commun, 5 3443 (2014)
    Hydrogen/deuterium exchange-protected oligomers populated during Aβ fibril formation correlate with neuronal cell death
    Serra-Vidal B, Pujadas L, Rossi D, Soriano E, Madurga S and Carulla N.
    Acs Chem Biol, 9 (11), 2678-85 (2014)
    From venoms to BBB shuttles: Synthesis and blood-brain barrier transport assessment of apamin and a nontoxic analog
    Oller-Salvia B, Teixidó M and Giralt E.
    Biopolymers, 100 (6), 675-86 (2013)
    Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis
    Nevola L, Martín-Quirós A, Eckelt K, Camarero N, Tosi S, Llobet A, Giralt E and Gorostiza P.
    Angew Chem Int Edit, 52 (30), 7704-8 (2013)
    Shuttle-Mediated Drug Delivery to the Brain
    Malakoutikhah M, Teixidó M and Giralt E.
    Angew Chem Int Edit, 50 7998-8014 (2011)
    Design, synthesis and characterization of a new anionic cell-penetrating peptide: SAP(E)
    Martín I, Teixidó M and Giralt E.
    Chembiochem, 12 (6), 896-903 (2011)
    Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties
    Sánchez L, Madurga S, Pukala T, Vilaseca M, López-Iglesias C, Robinson CV, Giralt E and Carulla N.
    J Am Chem Soc, 133 (17), 6505-8 (2011)
    Structure and intermolecular dynamics of aggregates populated during amyloid fibril formation studied by hydrogen/deuterium exchange
    Carulla N, Zhou M, Giralt E, Robinson CV and Dobson CM.
    Accounts Chem Res, 43 (8), 1072-9 (2010)
    Stability and structural recovery of the tetramerization domain of p53-R337H mutant induced by a designed templating ligand
    Gordo S, Martos V, Santos E, Menéndez M, Bo C, Giralt E and de Mendoza J.
    P Natl Acad Sci Usa, 105 (43), 16426-31 (2008)
    Redesign of protein domains using one-bead-one compound combinatorial chemistry
    Pastor JJ, Granados G, Carulla N, Rabanal F and Giralt E
    J Am Chem Soc, 129 14922-32 (2007)
    Replacement of a proline with silaproline causes a 20-fold increase in the cellular uptake of a pro-rich peptide
    Pujals S, Fernandez-Carneado J, Kogan M, Martinez J, Cavelier F and Giralt E
    J Am Chem Soc, 128 8479-83 (2006)
    Full publication list