Aikaterini Sfyaki

Unit:

Mechanisms of Disease

Position:

PhD Student

Office:

EM01B24

Telephone:

+34 93 40 37123

Email:

aikaterini.sfyaki@irbbarcelona.org

Research Group

Targeted protein degradation and drug discovery

Mechanisms of Disease

Selected group publications

Biophysical and computational approaches to study ternary complexes: A 'cooperative relationship' to rationalize targeted protein degradation

Ward JA, Perez-Lopez C, Mayor-Ruiz C

Chembiochem

(10 )

e202300163 -

e202300163

(2023)

Molecular glue degraders: From serendipity to hunting and design

Nieto-Barrado L; Domostegui A; Mayor-Ruiz C

In: Inducing Targeted Protein Degradation: From Chemical Biology To Drug Discovery And Clinical Applications. Ed: Wiley-Vch.

Chapter 6

177 -

204

(2022)

Chasing molecular glue degraders: screening approaches

Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C

Chemical Society Reviews

(13 )

5498 -

5517

(2022)

Identification and selectivity profiling of small-molecule degraders via multi-omics approaches

Scholes NS; Mayor-Ruiz C; Winter GE

Cell Chemical Biology

(7 )

1048 -

1060

(2021)

Rational discovery of molecular glue degraders via scalable chemical profiling

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Mueller, A.C., Zuber, J., Geyer, M., Thomä, N.H., Kubicek, S., Winter, G.E

Nat Chem Bio

(2020)