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Research

At the forefront of biomedicine

Ignasi Toledano

about us
Unit:
Position:
Alumni - PhD Student
Office:
CL01C74
Telephone:
+34 93 40 39954
Left IRB Barcelona in September 2024
Research Group

Selected group publications

TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
Alvarez, MM; Biayna, J; Supek, F
Nature Communications,
13
(1 )
4520
(2022)
The impact of rare germline variants on human somatic mutation processes
Vali-Pour, M; Lehner, B; Supek, F
Nature Communications,
13
(1 )
3724
(2022)
Mutational signatures are markers of drug sensitivity of cancer cells
Levati, J; Salvadores, M; Fuster-Tormo, F; Supek, F
Nature Communications,
13
(1 )
2926
(2022)
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells
Biayna, J; Garcia-Cao, I; Alvarez, MM; Salvadores, M; Espinosa-Carrasco, J; McCullough, M; Supek, F; Stracker, TH
Plos Biology,
19
(3 )
e3001176
(2021)
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
Mas-Ponte, D; Supek, F
Nature Genetics,
52
(9 )
958
(2020)
Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns
Salvadores, M; Fuster-Tormo, F; Supek, F
Science Advances,
6
(27 )
eaba1862
(2020)
The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy
Lindeboom, RGH; Vermeulen, M; Lehner, B; Supek, F
Nature Genetics,
51
(11 )
1645
(2019)