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Research

At the forefront of biomedicine

Institutional selected publications

Phylogenomics of Asgard archaea reveals a unique blend of prokaryotic-like horizontal transfer and eukaryotic-like gene duplication
Manzano-Morales, Saioa; Gabaldon, Toni
Nature Communications,
17
(1)
5103
(2026)
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Bernabeu, Moises; Manzano-Morales, Saioa; Marcet-Houben, Marina; Gabaldon, Toni
NATURE,
(2026)
Targeted KRASG12V Degradation in vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis
Martín, Alberto; García-Pérez, Inés M.; San José, Sonia; Rojo, Pep; Riego-Mejías, Carlos; Teodosio, Cristina; Barbosa, Bárbara MG.; Sánchez-Zarzalejo, Carolina; Folch-I-Casanovas, Ignasi; Odena-Caballol, Antonia; Jarió, Sònia; Hijazo-Pechero, Sara; Rodríguez-López, Silvia M.; Entrialgo-Cadierno, Rodrigo; Nokin, Marie-Julie;...
CANCER RESEARCH,
(2026)
Proteostasis failure and mitochondrial dysfunction contribute to chromosomal instability-induced microcephaly
Gonzalez-Blanco, Amanda; Acuna-Higaki, Adrian; Boettger, David; Joy, Jery; Milan, Marco
Nature Communications,
17
(1)
3829
(2026)
Stromal biomarker-based framework for identifying pMMR/MSS and dMMR/MSI colorectal cancers with poor outcomes and limited benefit from immunotherapy
Iglesias Coma, Mar; Badia-Ramentol, Jordi; Martinez-Ciarpaglini, Carolina; Linares, Jenniffer; Tarazona, Noelia; Mulet-Margalef, Nuria; Tornero-Pinero, Paula; Sallent-Aragay, Anna; Recort-Bascuas, Alba; Gibert, Joan; Sant-Albors, Marta; Tauriello, Daniele V F; Cruz-Moral, Melba; Carreras-Gallardo, Marina; Sancho, Elena; Morral Martinez, Clara;...
GUT,
(2026)
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells
Heras-Murillo, Ignacio; Mañanes, Diego; Calafell-Segura, Josep; (...); Ballestar, Esteban; Wculek, Stefanie K. (*); Sancho, David (*)
(*) Senior and Corresponding authors
Cell Metabolism,
38
(6)
1254
(2026)
Posttranscriptional reprogramming controls MASLD progression through chronic ER stress adaptation
Belloc, Eulalia; Calderone, Vittorio; Naranjo-Suarez, Salvador; Mateo, Lidia; Martin, Judit; Malizia, Florencia; Sibilio, Annarita; Chanes, Veronica; Ramirez-Pedraza, Marta; Delgado, M Eugenia; Drebber, Uta; Rheinwalt, Karl-Peter; Klein, Sabine; Brol, Maximilian Joseph; Schierwagen, Robert; Trebicka, Jonel; Aloy, Patrick; Fernandez, Mercedes;...
Science Advances,
12
(14)
eaea4125
(2026)
Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule
Bielskute-García, S; Mateos, B; Awawdy, M; Garcia-Cabau, C; Niskanen, H; Sánchez-Zarzalejo, C; Bracaglia, L; Pierattelli, R; Felli, IC; Frigolé-Vivas, M; García, J; Riera, A; Hnisz, D; Salvatella, X
Science Advances,
12
(9)
eadz7400
(2026)
A Plastic EMP1+ to LGR5+ Cell State Conversion as a Bypass to KRASG12D Pharmacologic Inhibition in Metastatic Colorectal Cancer
Centonze, Alessia; Roura, Adria-Jaume; Novillo-Font, Meritxell; Giordano, Cristina; Hernando-Momblona, Xavier; Llanses, Montserrat; Prats, Paula; Sevillano, Marta; Cabot, Debora; Novell, Mireia; Pabst, Gabriel; Andersch, Florian; Canellas-Socias, Adria; Zhang, Chong; Giakoumakis, Nikolaos-Nikiforos; Sparks, Hugh; Dunsby, Chris; Colombelli,...
Cancer Discovery,
16
(2)
320
- 344
(2026)
Structures of Vibrio cholerae transcription complexes reveal how ToxR and TcpP recruit the RNA polymerase and activate virulence genes
Alcaide-Jiménez, A; Canals, A; Baudin, F; Machón, C; Fàbrega-Ferrer, M; Bantysh, O; Pérez-Luque, R; Murciano, B; Mohammad, AA; Rowse, MJ; Ferracciolo, JM; Krukonis, ES; Müller, CW; Coll, M
Science Advances,
12
(3)
eadx9680
(2026)
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Scherer, Michael; Singh, Indranil; Maria Braun, Martina; Szu-Tu, Chelsea; Sanchez Sanchez, Pedro; Lindenhofer, Dominik; Jakobsen, Niels Asger; Korber, Verena; Kardorff, Michael; Nitsch, Lena; Kautz, Pauline; Ruhle, Julia; Bianchi, Agostina; Cozzuto, Luca; Fromel, Robert; Beneyto-Calabuig, Sergi; Lareau, Caleb; Satpathy, Ansuman T; Beekman, Renee;...
NATURE,
643
(8071)
478
(2025)
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
Henriques; A; Salvany-Celades; M; Nieto; P; Palomo-Ponce; S; Sevillano; M; Hernando-Momblona; X; Middendorp-Guerra; E; Llanses Martinez; M; Haak; EM; Nieto; JC; Caratù; G; Marchese; D; Ruiz-Gil; M; Tosi; S; Suckert; T; Badia-Ramentol; J; Caballé-Mestres; A; Sánchez-Zarzalejo; C; Mateo; L; Tauriello; DVF; Riera; A; Sancho; E; Stephan-Otto...
NATURE GENETICS,
53
3050
- 3065
(2025)
Sex and smoking bias in the selection of somatic mutations in human bladder
Calvet, F; Martinez-Illescas, RB; Muiños, F; Tretiakova, M; Latorre-Esteves, ES; Fredrickson, J; Andrianova, M; Pellegrini, S; Huber, AR; Ramis-Zaldivar, JE; An, SC; Thieme, E; Kohrn, BF; Grau, ML; Gonzalez-Perez, A; Lopez-Bigas, N; Risques, RA
NATURE,
647
(8089)
436
- 444
(2025)
Spatiotemporal T-cell tracking for personalized T-cell receptor T-cell therapy designs in childhood cancer
Sentís, I; Melero, JL; Cebria-Xart, A; Grzelak, M; Soto, M; Michel, A; Rovira, Q; Rodriguez-Hernandez, CJ; Caratù, G; Urpi, A; Sauvage, C; Mendizabal-Sasieta, A; Maspero, D; Lavarino, CE; Pascual-Reguant, A; Heredia, AC; Perez, JPM; Mora, J; Harari, A; Nieto, JC; Avgustinova, A; Heyn, H
ANNALS OF ONCOLOGY,
36
(9)
1096
- 1106
(2025)
Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue
Sánchez-Feutrie, M; Romero, M; Veiga, SR; Borràs-Ferré, N; Berrow, N; Ràfols, M; Giménez, N; Rodgers-Furones, A; Sabaté-Pérez, A; Pérez, AR; Cataldo, LR; Burghardt, H; Sebastián, D; Plana, N; Hernández, V; Alcaide, LI; Reina, O; Monte, MJ; Marin, JJG; Palacín, M; Burcelin, R; Antonson, P; Gustafsson, JA; Zorzano, A
Nature Communications,
16
(1)
7033
(2025)
DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy
Khalil, A; Supek, F
Nature Communications,
16
(1)
4209
(2025)
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse
Heras-Murillo, I; Mañanes, D; Munné, P; Núñez, V; Herrera, J; Catalá-Montoro, M; Alvarez, M; del Pozo, MA; Melero, I; Wculek, SK (*); Sancho, D (*)
(*) Senior and Corresponding authors
Nature Communications,
16
(1)
3369
(2025)
Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response
Ricolo, D; Casanova, J; Giannios, P
Science Advances,
11
(13)
eads2086
(2025)
Transcriptional heterogeneity shapes stress-adaptive responses in yeast
Nadal-Ribelles, M; Lieb, G; Solé, C; Matas, Y; Szachnowski, U; Andjus, S; Quintana, M; Romo, M; Herrero, AG; Morillon, A; Pelet, S; de Nadal, E; Posas, F
Nature Communications,
16
(1)
2631
(2025)
A single-cell resolved genotype-phenotype map using genome-wide genetic and environmental perturbations
Nadal-Ribelles, M; Solé, C; Díez-Villanueva, A; Attolini, CSO; Matas, Y; Steinmetz, L; de Nadal, E; Posas, F
Nature Communications,
16
(1)
2645
(2025)
Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemic driver mutations
Singh, I; Fernandez-Perez, D; Sanchez, PS; Rodriguez-Fraticelli, AE
Cell Stem Cell,
32
(4)
564
- 580
(2025)
Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD
Garcia-Cabau C; Bartomeu A; Tesei G; Cheung KC; Pose-Utrilla J; Picó S; Balaceanu A; Duran-Arqué B; Fernández-Alfara M; Martín J; De Pace C; Ruiz-Pérez L; García J; Battaglia G; Lucas JJ; Hervás R; Lindorff-Larsen K; Méndez R; Salvatella X
NATURE,
637
(8045)
496
- 503
(2025)
Five latent factors underlie response to immunotherapy
Usset, J; Huber, AR; Andrianova, MA; Batlle, E; Carles, J; Cuppen, E; Elez, E; Felip, E; Gómez-Rey, M; Lo Giacco, D; Martinez-Jimenez, F; Muñoz-Couselo, E; Siu, LL; Tabernero, J; Vivancos, A; Muiños, F; Gonzalez-Perez, A; Lopez-Bigas, N
NATURE GENETICS,
56:
(10)
2112
- 2120
(2024)
Comprehensive detection and characterization of human druggable pockets through binding site descriptors
Comajuncosa-Creus, Arnau; Jorba, Guillem; Barril, Xavier; Aloy, Patrick
Nature Communications,
15
(1)
7917
(2024)
Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells
López-Polo, V; Maus, M; Zacharioudakis, E; Lafarga, M; Attolini, CSO; Marques, FDM; Kovatcheva, M; Gavathiotis, E; Serrano, M
Nature Communications,
15
(1)
7378
(2024)
Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules
Toledano, I; Supek, F; Lehner, B
NATURE GENETICS,
56
(9)
1914
- 1924
(2024)
Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver mutations
Besedina, E; Supek, F
Nature Communications,
15
(1)
6139
(2024)
An integrated machine-learning model to predict nucleosome architecture
Sala, A; Labrador, M; Buitrago, D; De Jorge, P; Battistini, F; Heath, IB; Orozco, M
NUCLEIC ACIDS RESEARCH,
52
(17)
10132
- 10143
(2024)
Formation of left-handed helices by C2′-fluorinated nucleic acids under physiological salt conditions
El-Khoury, Roberto; Cabrero, Cristina; Movilla, Santiago; Kaur, Harneesh; Friedland, David; Dominguez, Arnau; Thorpe, James D; Roman, Morgane; Orozco, Modesto; Gonzalez, Carlos; Damha, Masad J
NUCLEIC ACIDS RESEARCH,
52
(13)
7414
- 7428
(2024)
CGeNArate: a sequence-dependent coarse-grained model of DNA for accurate atomistic MD simulations of kb-long duplexes
Farre-Gil, David; Arcon, Juan Pablo; Laughton, Charles A; Orozco, Modesto
NUCLEIC ACIDS RESEARCH,
52
(12)
6791
- 6801
(2024)
Brain-muscle communication prevents muscle aging by maintaining daily physiology
Kumar, A; Vaca-Dempere, M; Mortimer, T; Deryagin, O; Smith, JG; Petrus, P; Koronowski, KB; Greco, CM; Segales, J; Andres, E; Lukesova, V; Zinna, VM; Welz, PS; Serrano, AL; Perdiguero, E; Sassone-Corsi, P; Benitah, SA; Munoz-Canoves, P
SCIENCE,
384
(6695)
563
- 572
(2024)
The epidermal circadian clock integrates and subverts brain signals to guarantee skin homeostasis
Mortimer, T; Zinna, VM; Atalay, M; Laudanna, C; Deryagin, O; Posas, G; Smith, JG; Garcia-Lara, E; Vaca-Dempere, M; de Assis, LVM; Heyde, I; Koronowski, KB; Petrus, P; Greco, CM; Forrow, S; Oster, H; Sassone-Corsi, P; Welz, PS; Munoz-Cánoves, P; Benitah, SA
Cell Stem Cell,
31
(6)
834
- 849
(2024)
Cyclometallated Imides as Templates for the H‐Bond Directed Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Methyl, N‐Alkyl and N‐Aryl Imines
Wen, Yisong; Fernández‐Sabaté, Marc; Lledós, Agustí; Sciortino, Giuseppe; Eills, James; Marco‐Rius, Irene; Riera, Antoni; Verdaguer, Xavier
Angewandte Chemie,
63
(26)
e202404955
(2024)
Origins of Second Malignancies in Children and Mutational Footprint of Chemotherapy in Normal Tissues
Sanchez-Guixé, M; Muinos, F; Pinheiro-Santin, M; Gonzalez-Huici, V; Rodriguez-Hernandez, CJ; Avgustinova, A; Lavarino, C; Gonzalez-Pérez, A; Mora, J; López-Bigas, N
Cancer Discovery,
14
(6)
953
- 964
(2024)
Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis
Demajo, S; Ramis-Zaldivar, JE; Muiños, F; Grau, ML; Andrianova, M; López-Bigas, N; González-Pérez, A
Cancer Discovery,
14
(9)
1717
- 1731
(2024)
Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
Rullo-Tubau, Josep; Martinez-Molledo, Maria; Bartoccioni, Paola; Puch-Giner, Ignasi; Arias, Angela; Saen-Oon, Suwipa; Stephan-Otto Attolini, Camille; Artuch, Rafael; Diaz, Lucia; Guallar, Victor; Errasti-Murugarren, Ekaitz; Palacin, Manuel; Llorca, Oscar
Nature Communications,
15
(1)
2986
(2024)
Mutation rate heterogeneity at the sub-gene scale due to local DNA hypomethylation
Mas-Ponte, D; Supek, F
NUCLEIC ACIDS RESEARCH,
52
(8)
4393
- 4408
(2024)
The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization
Puerto, M; Shukla, M; Bujosa, P; Pérez-Roldán, J; Torràs-Llort, M; Tamirisa, S; Carbonell, A; Solé, C; Puspo, JA; Cummings, CT; de Nadal, E; Posas, F; Azorín, F; Rowley, MJ
NUCLEIC ACIDS RESEARCH,
52
(10)
5596
- 5609
(2024)
Site-specific incorporation of a fluorescent nucleobase analog enhances i-motif stability and allows monitoring of i-motif folding inside cells
Mir, B; Serrano-Chacón, I; Medina, P; Macaluso, V; Terrazas, M; Gandioso, A; Garavís, M; Orozco, M; Escaja, N; González, C
NUCLEIC ACIDS RESEARCH,
52
(6)
3375
- 3389
(2024)
PD-L2 expression in senescent cancer cells limits tumor clearance after chemotherapy
Lopez-Dominguez, JA; Chaib, S; Serrano, M
Nature Cancer,
5
(3)
382
- 383
(2024)
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
Chaib, S; López-Domínguez, JA; Lalinde-Gutiérrez, M; Prats, N; Marin, I; Boix, O; García-Garijo, A; Meyer, K; Muñoz, MI; Aguilera, M; Mateo, L; Attolini, CSO; Llanos, S; Pérez-Ramos, S; Escorihuela, M; Al-Shahrour, F; Cash, TP; Tchkonia, T; Kirkland, JL; Abad, M; Gros, A; Arribas, J; Serrano, M
Nature Cancer,
5
(3)
448
- 462
(2024)
Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers
Salvadores, M; Supek, F
Nature Cancer,
5
(2)
330
- 346
(2024)
Mucosal TLR5 activation controls healthspan and longevity
Lim, JS; Jeon, EJ; Go, HS; Kim, HJ; Kim, KY; Nguyen, TQT; Lee, DY; Kim, KS; Pietrocola, F; Hong, SH; Lee, SE; Kim, KS; Park, TS; Choi, DH; Jeong, YJ; Park, JH; Kim, HS; Min, JJ; Kim, YS; Park, JT; Cho, JH; Lee, GW; Lee, JH; Choy, HE; Park, SC; Lee, CH; Rhee, JH; Serrano, M; Cho, KA
Nature Communications,
15
(1)
46
- 46
(2024)
Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Schikora-Tamarit, MA; Gabaldón, T
Nature Microbiology,
9
(1)
284
- 307
(2024)
Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders
Barbosa, BMG; Sfyaki, A; Rafael, S; Jose-Duran, F; Pous, J; Sánchez-Zarzalejo, C; Perez-Lopez, C; Vilanova, M; Cigler, M; Gay, M; Vilaseca, M; Winter, GE; Riera, A; Mayor-Ruiz, C
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
63
(12)
e202316730
- e202316730
(2024)