News

Scientific news
<p>Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona</p>
16 Aug 2018

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism

Published in Nature, the study indicates that a defect in CPEB4 could be the link between environmental factors that alter brain development and the genes that determine susceptibility to autism

Scientific news
<p>Structure of TGIF1, attached to DNA.</p>
13 Aug 2018
  • A group of scientists headed by Maria Macias, ICREA researcher at IRB Barcelona, describes the mechanism through which TGIF1 inhibits the activity of Smad proteins.
  • The study, which used molecular and structural biology techniques to analyse this interaction, has been published in Nucleic Acids.
Scientific news
<p>TLK inhibition leads to replication stress (green) and extensive DNA damage (red) in cultured cancer cells. Sandra Segura-Bayona, IRB Barcelona.</p>
8 Aug 2018

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials

Scientific news
<p>Miquel Duran-Frigola, Associate Researcher at the Structural Bioinformatics and Network Biology lab, IRB Barcelona</p>
31 Jul 2018

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH.

The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

Scientific news
<p>The figure shows two views, frontal and lateral, of the image obtained by CT of the lungs of a mouse with fibrosis (grey areas) before and after receiving nano-therapy directed at senescent cells. (Guillem Garaulet and Francisca Mulero, CNIO)</p>
26 Jul 2018

A team headed by Manuel Serrano at IRB Barcelona has designed a drug encapsulation system that selectively targets senescent cells.

The study paves the way for therapeutic approaches to eliminate senescent cells in many diseases, such as pulmonary fibrosis and cancer.

Institutional news
25 Jul 2018

The scientist Roger Gomis receives funding from the “la Caixa” Foundation for a project devoted to metastatic breast cancer.

Scientific news
<p>Diversity is key: metagenomes from different enviroments can predict different types of gene functions (Graphic, F Supek, IRB Barcelona)</p>
17 Jul 2018

An international team led by computational biologist Fran Supek at IRB Barcelona develop a machine learning method to predict unknown gene functions of microbes.

The system examines and compares ‘big data’ available on the metagenomes of human and environmental microbiomes.

Scientific news
<p>Intestine of a patient  with ulcerative colitis, a chronic inflammatory disease of the intestine. Macrophage marker is shown in green, activated p38 protein in red, and nucleus in blue. Author: Catrin Youssif, IRB Barcelona</p>
11 Jul 2018

A new study by researchers at IRB Barcelona demonstrates that myeloid cells, which belong to the leucocyte family and form part of the innate immune system, use p38 protein signalling to support inflammation-associated colon cancer.

Published in EMBO Molecular Medicine, the study by Angel R. Nebreda suggests that inhibition of the p38 pathway in myeloid cells may be a useful therapeutic approach, especially in tumours associated with chronic inflammation.

Scientific news
<p>Image: CRG</p>
9 Jul 2018

Researchers at the Centre for Genomic Regulation (CRG) in collaboration with IRB Barcelona, developed a new method to systematically identify genes contributing to heritable cancer risk.

The study, published in Nature Communications, is a success story for data sharing and openness in science.

Institutional news
<p>Image: La Pedrera</p>
6 Jul 2018

BIYSC 2018 starts with 90 students from all over the world.

IRB Barcelona receives today eight students that will participate through the workshop "Drosophila melanogaster: a model to study human disease".