News

Scientific news
<p>Figure showing the binding of a nanobody derived from alpaca to the EGF protein. The scientists demonstrate the high affinity and selectivity of a family of nanobodies for EGF, target of interest for the treatment of cancer (S Guardiola, IRB Barcelona)</p>
2 Oct 2018

A study done at IRB Barcelona and the Vrije Universiteit Brussel identifies camelid nanobodies able to block EGF, a protein that is abundant in tumour cells and that helps them to proliferate.

Scientific news
<p>Drosophila epithelium subjected to chromosomal instability (CIN): cells start invading the neighbouring tissues. Magenta labels the nuclei of all the epithelium while green labels the membranes of cells subjected to CIN (L Barrio, IRB Barcelona)</p>
26 Sep 2018

Most solid tumours with metastatic potential show a high degree of chromosomal instability.

A study published in the journal Developmental Cell demonstrates that chromosomal instability itself promotes invasive behaviour.

The researchers identify the oncogene Fos and the tumour suppressor Capicua as necessary molecular elements mediating this invasive behaviour.

Institutional news
<p>The AECC ceremony was held in Madrid yesterday, 25th September, the World Cancer Research Day</p>
25 Sep 2018

The projects address breast, lung, colon, prostate and melanoma cancer.

Institutional news
<p>"Legado Solidario" Campaign. Source: Legadosolidario.org</p>
13 Sep 2018

25 non-profit organisations working in the fields of social welfare, the environment, and biomedical research and associated with the LegadoSolidario.org campaign inform the public about the possibility of including a donation to a cause or charity with which they identify.

According to data from 2015, only 1% of wills made in Spain included a charitable bequest.

Institutional news
<p>Eduard Batlle, head of the Colorectal Cancer laboratory at IRB Barcelona</p>
10 Sep 2018

IRB Barcelona has been awarded two ERC PoC grants to optimise and validate tools with potential clinical applications.

Angel R. Nebreda’s project seeks to develop treatments to reduce the cardiotoxicity caused by chemotherapy.

Eduard Batlle’s project will build a biobank of mouse tumour organoids with the aim to contribute to the treatment of patients with advanced colon cancer.

Institutional news
<p>Montserrat Romero, Antonio Zorzano, David Sebastián and Juan Pablo Muñoz from the Complex Metabolic Diseases and Mitochondria Lab at IRB Barcelona. Source: Fundación BBVA</p>
6 Sep 2018

A project headed by Antonio Zorzano at IRB Barcelona has been awarded funding from the BBVA Foundation to explore a possible link between ageing and cancer.

Called MitoFuss, the project focuses on the mitochondrial protein Mitofusin 2.

Institutional news
<p>Manuel Serrano, head of the Cellular Plasticity and Disease laboratory at IRB Barcelona</p>
3 Sep 2018

Manuel Serrano, ICREA researcher at IRB Barcelona, is the subject of the next video in the Meet Our Scientists series: “Killing zombie cells”.

In the video, Serrano talks about the work undertaken in his lab to find compounds that can remove damaged cells from the body.

Scientific news
<p>Raúl Méndez and Eulàlia Belloc from the Translational Control of Cell Cycle and Differentiation Lab at IRB Barcelona</p>
16 Aug 2018

The protein CPEB4, which coordinates the expression of hundreds of genes required for neuronal activity, is altered in the brains of individuals with autism

Published in Nature, the study indicates that a defect in CPEB4 could be the link between environmental factors that alter brain development and the genes that determine susceptibility to autism

Scientific news
<p>Structure of TGIF1, attached to DNA.</p>
13 Aug 2018
  • A group of scientists headed by Maria Macias, ICREA researcher at IRB Barcelona, describes the mechanism through which TGIF1 inhibits the activity of Smad proteins.
  • The study, which used molecular and structural biology techniques to analyse this interaction, has been published in Nucleic Acids.
Scientific news
<p>TLK inhibition leads to replication stress (green) and extensive DNA damage (red) in cultured cancer cells. Sandra Segura-Bayona, IRB Barcelona.</p>
8 Aug 2018

Published in Science Advances, the study shows that the TLK1 and TLK2 enzymes are critical for ensuring the copying of DNA.

Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death.

Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials