Noticias Científicas

<p>Antonio Zorzano and his team at the Complex Metabolic Diseases and Mitochondria Lab have participated in this study. IRB Barcelona.</p>
3 May 2019

Work headed by scientist Antonio Zorzano proposes a possible therapeutic target to treat fatty liver, a disease for which there is currently no treatment. 

The study, which was done in collaboration with the Pere Virgili Institute, has been published in the journal Cell.

<p>Structure of EGFR. Purple indicates the region recognised by mAB806. Laura Orellana.</p>
2 May 2019

The antibody mAb806 is used to treat glioblastoma, although its mechanism of action has been unknown until now. 

The study, published in the journal PNAS, paves the way to extend treatment with mAb806 to more types of tumours and to the development of more personalised therapies. 

<p>Structure of the BasC transporter. Manuel Palacín, IRB Barcelona.</p>
24 Apr 2019

Mutations in L-amino acid transporters (LATs) can lead to a wide range of conditions, such as autism, hearing loss and aminoacidurias.

Published in the journal Nature Communications, this study presents key data on how amino acids bind to these transporters.

The work is a collaboration between IRB Barcelona, CIBERER, IBMB-CSIC and the Barcelona Supercomputing Center.

<p>Different localization of the proteins involved in apoptosis in basal (Ctrl) and upon death receptor induction with TRAIL. Saška Ivanova, IRB Barcelona</p>
15 Apr 2019

Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis.

A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments.

<p>Picture of the three crystal systems examined in this study. These systems contain (from left to right) 27, 24 and 36 double-stranded DNA respectively. Pablo Dans Puiggròs, IRB Barcelona.</p>
21 Jan 2019

The breakthrough made by researchers at IRB Barcelona allows the study of the role of each molecular component in the stability and conformation of DNA crystals.

The new molecular simulation techniques are expected to reduce the time and cost of obtaining crystals in the laboratory.

<p>Maximum likelihood phylogenetic tree based on ADAT2 and ADAT3 amino acid sequences. Source: Molecular Biology and Evolution</p>
10 Jan 2019

The study, published in the journal Molecular Biology and Evolution, has been headed by Lluís Ribas, at IRB Barcelona.

<p>Scheme of the intracellular processing of the 2shRNAs by the activity of Dicer enzyme, producing two independent fragments of shRNA, one against each target (M Terrazas, IRB Barcelona)</p>
21 Dec 2018

Modesto Orozco’s lab has published a paper in Chemical Communications about a therapeutic tool to prevent treatment resistance in breast cancer.

The tool has been tested in tumour cells in vitro and will now need to be tested in animal models before moving on to the development of a valid treatment for patients.

<p>A invasive front of highly aggressive tumour cells (in green). Confocal microscopy image. Alexandra Avgustinova, IRB Barcelona.</p>
19 Nov 2018

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.

Published in Nature Cell Biology, the study is a collaboration between a biomedical lab and a computational lab at IRB Barcelona.

<p>Giant Yellow Israeli scorpion. Image: Ester Inbar</p>
14 Nov 2018

Researchers at IRB Barcelona modify chlorotoxin—a small protein present in scorpion venom with blood-brain barrier permeability—to transport drugs into the brain. 

The barrier, which protects the brain, prevents drugs used for the treatment of neurological diseases and brain tumours from entering the organ.

<p>Skin of a young mouse. The image shows a cross section of the skin with the fibroblasts indicated in green. The thickness of the dermis and the density of fibroblasts is much greater in young skin than in aged skin– cell nuclei, in blue (M Salzer, IRB Bar</p>
8 Nov 2018

A study in mice done at IRB Barcelona and CNAG-CRG explains that dermal fibroblasts lose their cell identify over time and with it their capacity to produce and secrete collagen and other proteins.