Scientific News

<p>Left, atomic structure of RNA polymerase I in its inactive form - homodimer; Right, atomic structure of RNA polymerase I in its active form -heterodimer with Rrn3-. (Carlos Fernández-Tornero CIB/CSIC and Oriol Gallego, IRB Barcelona)</p>
16 Mar 2017

Researchers unveil a mechanism responsible for halting protein synthesis when cells are deprived of nutrients.

The cell regulates its growth by forming various assemblies of RNA polymerase I.

The study has implications for cancer research.

<p>The image shows tumour cells infected by the virus, which expresses a fluorescent protein. Over the days (in the image fifth day), the virus multiplies, generating new virions that infect more cancer cells (IDIBAPS, IRB Barcelona)</p>
16 Mar 2017

IDIBAPS and IRB Barcelona researchers show the effectiveness of a new strategy to achieved genetically modified viruses that infect only tumor cells, thus preserving healthy tissues.

It is an innovative approach that exploits the different expression profiles of certain proteins between tumor and healthy cells, thus allowing the virus to infect only the former.

 

<p>After chemotherapy, quiescent cells change their  behaviour​, become active​ ​and regenerate all cell types in the intestine (in green). (F Barriga, IRB Barcelona)</p>
9 Mar 2017

These comprise a small group of passive stem cells—quiescent—that are activated when needed and have the capacity to produce any kind of intestinal cell.

Quiescent cells are relevant for tissue regeneration and for their participation in tumour development.

<p>On the left, in vivo image of nanomachines using current microscopy techniques; on the right, the new method allows 3D observation of nanomachines in vivo and provides 25-fold improvement in resolution  (O. Gallego, IRB Barcelona)</p>
26 Jan 2017

Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3D the protein machinery inside living cells

Published in the journal Cell, the study unveils key functional features of an assembly of proteins that is vital for animals and plants.

With this new strategy in hand, it will be possible to study cellular protein machinery in health and in disease.

<p>Staining of mouse liver sections showing steatosis of the liver (fatty liver), with accumulation of fat, lipid droplets (in red), within cells. Cell nuclei stain blue (C. Maíllo, IRB Barcelona).</p>
17 Jan 2017

It is a disease of the liver caused by excessive fat deposits in liver cells.

It is now the most prevalent chronic liver disease in industrialised countries and is a major public health concern because it leads to serious liver conditions.

 

<p>Examples of computationally designed proteins made of curved beta-sheets and helices forming cavities with different sizes and shapes (E.Marcos, IRB Barcelona-UW)</p>
13 Jan 2017

The international team achieved it by discovering the rules behind a type of protein structures that are essential for the interaction between proteins and small molecules

IRB Barcelona researcher, Enrique Marcos, is the first author of the study published today in Science

<p>Ectopic wings upon ectopic activation of JAK/STAT (Carles Recasens-Alvarez and Ana Ferreira, IRB Barcelona)</p>
9 Jan 2017

Researchers at IRB Barcelona identify a fundamental role of the JAK/STAT signalling pathway in the development and growth regulation of limbs in Drosophila.

Published in Nature Communications, the study paves the way to research into the function of this pathway in vertebrate development and its possible involvement in human congenital diseases.

<p>Despite the expanding repertoire of new anti-cancer agents, treatment failure remains a major challenge in the management of most advanced solid tumours, including breast cancer.</p>
20 Dec 2016

A bioinformatics analysis of pairing 64 drugs used to treat breast cancer allows researchers at IRB Barcelona to identify 10 previously untested combinations with potential to tackle resistance to breast cancer treatment.

In spite of the many drugs available to treat breast cancer, resistance continues to be a problem.

<p>Iproteos is currently performing the regulatory preclinical phase of its drug candidate for CIAS treatment.</p>
19 Dec 2016

Compound IPR19, a drug to stop the progression and reverse the cognitive deficits associated with schizophrenia.

<p>Group leader Salvador Aznar Benitah and first author Gloria Pascual in the Stem Cells and Cancer lab at the IRB Barcelona (M. Minocri, IRB Barcelona)</p>
7 Dec 2016

A study at IRB Barcelona has identified the cells responsible for initiating and promoting metastasis in several types of human tumours.

Their results show that the protein CD36, which absorbs fat from the cell membrane, is an essential factor that determines whether tumour cells become metastatic.

In the absence of CD36, the human tumours analysed did not develop metastasis. In addition, the inhibition of this protein also dramatically reduced the size of existing metastases.

Mice given a high-fat diet developed the most aggressive metastases. The study reports that the metastatic process is enhanced by fat intake.

IRB Barcelona will co-develop antibodies against CD36 with the potential to treat patients.