Scientific News

<p>In the picture, Núria López-Bigas and the team that published the study in Nature Genetics this week.</p>
7 Nov 2017

A study published by IRB Barcelona in Nature Genetics demonstrates that the error (mutation) surveillance and repair system shows greater efficiency in the protein-coding regions of genes.

<p>Picture showing the metastasis of a primary breast tumour to bone (Author: Formas Naturales by Inbiomotion, IRB Barcelona)</p>
19 Oct 2017

A study published in the Lancet Oncology by an international team led by Prof Rob E. Coleman (University of Sheffield) and Prof Roger R. Gomis (IRB Barcelona) identifies the effect of MAF amplification on the outcome of treatment with adjuvant zoledronic acid in early breast cancer.

This new knowledge may be key to the early detection of patients who would benefit from zoledronic acid and those who should be spared, and both reduce disease recurrence and deaths from breast cancer.

Inbiomotion, an IRB Barcelona spin off company and financed by venture investors Ysios Capital and Caixa Capital Risc, will soon start a confirmatory trial.

<p>Tumour (red) covered by collagen (green), which is being deposited by cells of the immune system (cyan). (Image: Mariana Muzzopappa, IRB Barcelona)</p>
7 Sep 2017

Researchers at IRB Barcelona reveal the capacity of epithelial-derived tumours to grow in the absence of a microenvironment.

Featured on the cover of the journal Proceedings of the National Academic of Sciences (PNAS), the study identifies the cell types and molecular mechanism involved in tumour initiation and growth.

The results of this study contribute to our understanding of the internal mechanisms of the tumour, which may provide a therapeutic target.

<p>Drosophila polytene chromosome. In yellow, the chromocenter region where heterochromatin is accumulated. Image: Jordi Bernués, IRB Barcelona.</p>
16 Aug 2017

Genomic instability is the main risk factor for tumour development in humans. Therefore understanding its origin and exploring therapeutic targets is paramount.

Histone 1 silences a region of the genome that causes irreparable DNA damage when translated and is lethal for the organism.

<p>Image representing the effects of the circadian clock in ageing (Author: Iris Joval Granollers)</p>
10 Aug 2017

Stem cell functions continue to be governed by day and night cycles (circadian rhythms) during ageing, but their rhythms become devoted to tissue repair and not to the maintenance of tissue tone.

The two studies published in Cell and headed by Salvador Aznar Benitah at IRB Barcelona reject the scientific dogma associating ageing with the loss of stem cell circadian rhythm.

A low-calorie diet delays alterations in the rhythmic functions of stem cells and slows down ageing.

<p>Fran Supek is the first author of the study published today in Cell. Supek developed this work while he was working with Ben Lehner at CRG (Photo: M Minocri, IRB Barcelona)</p>
27 Jul 2017

Fran Supek (IRB Barcelona) and Ben Lehner (CRG) identify important processes that create mutations that cause cancer by studying the genomes of more than 1,000 tumors.

Many mutations in human cancers are caused by mistakes made by a repair mechanism or ‘DNA spellchecker’ rather than the actual damage to DNA caused by the environment.

Sunlight and alcohol consumption increase the rate at which this happens, resulting in more mutations in the most important parts of our genomes.

 

<p>3D structure of the protein relaxase bound to a DNA fragment. The histidine residue that performs the DNA nicking, is shown in blue (bottom right) (Radoslaw Pluta, IRB Barcelon</p>
26 Jul 2017

Scientists at IRB Barcelona identify a key component of the machinery that allows Staphylococcus aureus to transfer genes that confer antibiotic resistance. 

Infection by antibiotic-resistant S. aureus is a serious threat in hospitals worldwide.

Halting the spread of antibiotic-resistant bacteria is one of the strategies available to tackle hospital infections.

<p>The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to study fundamental processes involved in gene regulation. Image: microscopy, Eulàlia Belloc.</p>
18 Jul 2017

Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.

These findings will help researchers to better understand pathological processes such as cancer. 

<p>Cross sections of wild type or TLK2 deficient embryos stained for the proliferative marker Ki67. Embryos lacking TLK2 (left) appear morphologically normal but developmentally delayed. (S. Segura-Bayona, IRB Barcelona)</p>
17 Jul 2017

The work is the first to report on the key role of the TLK2 gene in mouse embryo development.

The study solidifies an important role for both TLK1 and TLK2 in genome stability.

A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.

<p>Glycogen (black particles) accumulates in large amounts in the muscle due to the absence of the protein glycogenin (Giorgia Testoni, IRB Barcelona)</p>
6 Jul 2017

A study published in Cell Metabolism by IRB Barcelona scientists turns long-standing assumptions about glycogen biology on their head.

The results may explain the muscular defects of patients with glycogen storage disease XV.