Conducted on the fly Drosophila, the study shows that tumours caused by chromosomal instability delay entry into the adult phase.
The tumours produce the Upd3 protein (equivalent to human Interleukin-6) to block the production of developmental steroid hormones.
The work of IRB Barcelona's Growth Control and Development laboratory has been published in the journal Current Biology.
Experiments carried out in the Drosophila fly have led to the identification of the headcase (hdc) gene as pivotal for adult progenitor cells, allowing them to undergo metamorphosis and give rise to adult tissue structures.
The study by IRB Barcelona’s Development and Morphogenesis in Drosophila lab has been published in PLOS Genetics.
This work paves the way for the in vitro study of the nucleation process that is essential for assembly and organisation of the microtubule cytoskeleton.
The paper is a collaboration between Jens Lüders’ group at IRB Barcelona and Oscar Llorca’s at CNIO.
The results have been published in Science Advances.
This work is a collaboration between Núria López-Bigas’ lab at IRB Barcelona and the groups headed by Anna Bigas (Hospital del Mar Medical Research Institute) and Josep Maria Ribera (Josep Carreras Leukaemia Research Institute).
The results have been published in Genome Biology.
A collaboration between the Development and Morphogenesis in Drosophila lab, led by Jordi Casanova at IRB Barcelona, and Marta Llimargas (IBMB-CSIC) has studied cell intercalation in the Drosophila trachea.
The work has been published in Open Biology.
By analysing duplicates of thousands of genes, researchers have reconstructed the evolutionary events leading to the creation of eukaryotic cells, the precursors to virtually all life you can see with the naked eye.
The evolutionary timeline from simple bacterial cells to complex eukaryotic cells progressed differently than previously thought.
The study, a collaboration between the Comparative Genomics lab at IRB Barcelona and the University of Utrecht, has been published in Nature Ecology & Evolution.
Diseases that stem from or are affected by defective amino acid transport, such as cancer, cystic fibrosis or neurodegenerative conditions, may benefit from advances in this field.
The work, a collaboration between the Amino Acid Transporters and Disease laboratory at IRB Barcelona and the Ballester group at ICIQ, has been published in the journal CHEM.
The collaboration has taken place under the BIST Ignite project CALIX4TRANS.
Researchers at IRB Barcelona’s Cellular Plasticity and Disease Laboratory propose a more efficient way to limit cell plasticity without causing cell damage.
The new method sheds light on processes in which cell plasticity is important, such as cancer and immunology.
The study has been published in the journal Nature Cell Biology and has been supported by ”la Caixa” Foundation.
Researchers from the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona develop a system to predict tumour response to different treatments.
Called Targeted Cancer Therapy for You (TCT4U), this system has allowed them to identify a set of complex biomarkers that are available to the medical-scientific community.
The work has been published in the journal Genome Medicine.
Analysis of the genomes of 28,000 tumours from 66 types of cancer has led to the identification of 568 cancer driver genes
Performed by the Biomedical Genomics Lab at IRB Barcelona, the study has allowed a major update of the Integrative OncoGenomics (IntOGen) platform, aimed at identifying mutational cancer driver genes.
Published in Nature Reviews Cancer, the results provide the most complete snapshot of the compendium of cancer driver genes to date.