Scientific News

2 Jul 2020

Of the 614 cell lines studied, 7% closely corresponded to a different type of cancer than that thought to give rise to the cell line.

The Genome Data Science Laboratory at IRB Barcelona has drawn up a reference list of 366 cell lines in which the genetic pattern corresponds to the type of tumour that they intend to model.

The work shows that studies using the cell lines on this reference list have a greater discovery rate, and has been published in the journal Science Advances.

 

<p>After APP cleavage at the neuronal membrane, Aβ protein self-assembles into 4 or 8 copies adopting an arrangement allowing passage of water and ions (in red) and thus disrupting ion cell homeostasis © Benjamin Bardiaux.</p>
26 Jun 2020

Researchers led by Natàlia Carulla find that specific amyloid-beta (Aβ) protein ensembles have the capacity to disrupt the membrane of neurons, causing their death.

The results have been published in the journal Nature communications.

<p>DNA lesions. Credit: Petra Korlevic</p>
25 Jun 2020

DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours, as lesions pass on unrepaired over several rounds of cell division.

A study by the Liver Cancer Evolution Consortium explores the evolution of tumours after chemical damage, offering interesting insights into how mutational processes work.

The work has been published in the journal Nature.

 

2 Jun 2020

A role of colibactin-producing E. coli in carcinogenesis.

19 May 2020

The Chemical Checker provides processed, harmonized and ready-to-use bioactivity information on more than 1M small molecules

The tool, developed by the Structural Bioinformatics and Network Biology lab at IRB Barcelona, has been published in Nature Biotechnology.

 

<p>Immunofluorescence of a mouse mammary gland duct (IRB Barcelona)</p>
18 May 2020

Researchers at IRB Barcelona discover a new mechanism in estrogen receptor-positive breast cancer cells.

The inhibition of CPEB2, a key factor in the estrogen signalling pathway, causes cancer cells to proliferate less and protects mice against luminal breast cancer.

 

<p>Tumour heterogeneity: cancer stem cells (green) and differentiated cells (in red). IRB Barcelona.</p>
12 May 2020

The Colorectal Cancer Lab at IRB Barcelona identifies the capacity to synthesize proteins (or biosynthetic capacity) as a key property for the regenerative potential of colon cancer cells.

Published in Cell Stem Cell, the study proposes a new therapeutic focus for the scientific community and the pharmaceutical industry to explore.

<p>Histone residues required for an adaptive response to an increase in temperature (blue) or salt concentration (red). IRB Barcelona.</p>
16 Apr 2020

More than 200 regions (amino acids) in histones are identified as responsible for regulating the response to cell stress.

The study reports that histones undergo distinct modifications depending on the type of cell stress.

The work by the Cell Signaling laboratory has been published in the journal Nucleic Acids Research.

7 Apr 2020

The Centre for Genomic Regulation (CRG) is coordinating a task force with the Institute for Research in Biomedicine (IRB Barcelona) and the Institute for Bioengineering of Catalonia (IBEC), as requested by Generalitat de Catalunya, to set up mass testing for citizens to stop the spread of the new coronavirus outbreak.

There will be two mass testing sites – one coordinated by the CRG at its labs at the Barcelona Biomedical Research Park (PRBB) and another at the Parc Cientific de Barcelona, jointly coordinated by IRB Barcelona, IBEC and the Centro Nacional de Análisis Genómico (CNAG-CRG), part of the CRG.

The project, codenamed Programa Orfeu by the Generalitat de Catalunya...

<p> Cells of the yeast Saccharomyces cerevisiae in  the mitosis phase of the cell cycle</p>
6 Apr 2020

The HOG signalling pathway regulates the stress response in the yeast Saccharomyces cerevisiae and halts cell division, thereby regulating the segregation of chromosomes through protein Net1.

The p38 signalling pathway in humans is equivalent to that of HOG and is involved in tumour development.

The study by the Signaling Laboratory at IRB Barcelona has been published in the journal PNAS.