The study, published in the journal Developmental Cell and performed in Drosophila, unravels how developmental genes regulate organ size and proportions.
Researchers at IRB Barcelona demonstrate that the size and patterning of a given organ are regulated by different mechanisms.
Given the high genetic and mechanistic conservation between flies and humans, these discoveries pave the way for new research lines into congenital malformations and other diseases
The study infers the genetic changes that coincided with the appearance of different groups of animals and their main traits.
Researchers at IRB Barcelona and BSC-CNS have confirmed that the dynamics of genomic evolution, in addition to the presence or absence of the genes themselves, determines diversity in the animal kingdom.
Published in Nature Ecology and Evolution, the study has been based for the first time on the genomic data of all the large groups of animals.
Ángel Nebreda’s team has published a study in the journal PNAS reporting the involvement of the protein p38 in the progression of lung cancer.
The work shows that patients with low levels of this protein have a better prognosis.
One of the biggest challenges faced by biomedicine is the development of more selective and efficient cancer treatments.
This species shows several genetic duplications, which may explain its high plasticity and capacity to adapt to diverse farming conditions.
CSIC has headed this research, which has brought about a considerable advance in the development of genomic and biotechnological tools to achieve more sustainable fish farming.
The findings of the study will be applied in genetic selection and environmental programming in order to improve fish quality and interaction with the microorganisms present in the host environment.
Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby leading to abnormal cell behaviour.
A machine-learning model has allowed the scientists to obtain the most extensive annotation of the ubiquitin-mediated protein degradation system.
The analysis proposes a potential new clinical approach for cancer through the inhibition of oncoproteins with impaired degradation systems.
Scientists at IRB Barcelona determine the genetic alterations in the cells of cancer patients caused by the main cancer therapies.
This is an important step towards understanding the long-term side effects and optimizing treatments against cancer.
The results have been published in the journal Nature Genetics.
Both transcription factors regulate the expression of genes involved in embryo development, among other functions, although they exert very different roles.
The study also refutes the theory accepted to date that SMAD2 does not bind to DNA.
Published in Genes & Development, the research is the result of collaboration between Maria J. Macias’ lab at IRB Barcelona and Joan Massagué’s group at the Sloan Kettering Institute (New York, US).
Using machine learning, researchers have built a tool that detects genetic mutations that trigger the immune system, helping identify which cancer patients are more likely to benefit from immunotherapy
The algorithm also reveals which people living with hereditary diseases may benefit from drugs that already exist
The new technology’s potential is described today in Nature Genetics by researchers at IRB Barcelona, the Centre for Genomic Regulation and Radboud University
Scientists shed light on how the genome organizes groups of genes linked to specific processes, like the release of toxins
They carried out a study on fungi and found more than 11,000 gene families grouped together or near each other in the genome
The results are published today in the journal Nature Microbiology