Scientific News

<p>The experiments have been carried out using Xenopus laevis oocytes, an animal model used by the laboratory to study fundamental processes involved in gene regulation. Image: microscopy, Eulàlia Belloc.</p>
18 Jul 2017

Published in the journal Nature Structural & Molecular Biology, the study reveals new insights into translation regulation, an essential step in genome regulation.

These findings will help researchers to better understand pathological processes such as cancer. 

<p>Cross sections of wild type or TLK2 deficient embryos stained for the proliferative marker Ki67. Embryos lacking TLK2 (left) appear morphologically normal but developmentally delayed. (S. Segura-Bayona, IRB Barcelona)</p>
17 Jul 2017

The work is the first to report on the key role of the TLK2 gene in mouse embryo development.

The study solidifies an important role for both TLK1 and TLK2 in genome stability.

A massive genomics study of people with intellectual disabilities performed in the Netherlands points to patient mutations in the TLK2 gene.

<p>Glycogen (black particles) accumulates in large amounts in the muscle due to the absence of the protein glycogenin (Giorgia Testoni, IRB Barcelona)</p>
6 Jul 2017

A study published in Cell Metabolism by IRB Barcelona scientists turns long-standing assumptions about glycogen biology on their head.

The results may explain the muscular defects of patients with glycogen storage disease XV.

<p>The top and bottom of the image show how the Dpp concentration gradient affects the organisation of the wing structure of Drosophila melanogaster. In the centre, in the absence of Dpp, the wing does not grow. Image: Lara Barrio.</p>
5 Jul 2017

Scientists at IRB Barcelona clarify the function of the genes that drive wing development in the fruit fly Drosophila melanogaster.

Published in the journal eLife, this study unveils that the Dpp morphogen is necessary for wing growth but that its gradient does not govern this process.

Understanding the development of limbs in Drosophila paves the way to research into congenital defects in vertebrates.

<p>Fluorescence microscopy image of the hypothalamus arcuate nucleus with POMC neurons in green (Image: Alicia G Gómez-Valadés).</p>
7 Jun 2017

A study co-led by IRB Barcelona and IDIBAPS emphasizes the importance of the neuronal mechanisms in the detection of nutrients and the control of glucose levels.

The results published in Cell Metabolism help to understand diabetes in greater detail.

<p>Representative images of different subtypes of skin tumors (L. Rinaldi, IRB Barcelona)</p>
25 May 2017

Researchers led by Salvador Aznar-Benitah at IRB Barcelona investigate the role of Dnmt3a and Dnmt3b proteins in skin homeostasis and tumour development in adult mice.

The study has been published in eLife and deserved an eLife digest aimed at a more general audience.

<p>Patient derived colorectal cancer in mice with LGR5-enhanced flourescent protein (EGFP) modification to follow the behaviour of cancer stem cells (image: G. Turon, IRB Barcelona)</p>
3 May 2017

In EMBO Molecular Medicine, IRB Barcelona scientists report a technique based on a combination of CRISPR/Cas9 genome editing and patient-derived tumour organoids that allows the study of cell heterogeneity in human tumours.

The novel approach was used to examine the behaviour of colorectal cancer stem cells by tracing specific marker genes.

<p>Researchers revealed details of the p38 activation mechanism. The image represents the structural changes from the inactive state (purple) to the active one (green) proposed by X-ray crystallography. Image: Antonija Kuzmanic.</p>
27 Apr 2017

p38α is a protein involved in chronic inflammatory diseases and cancer, among other pathological conditions.

Published in the journal eLife, the study provides a deeper understanding of the structure of this protein, thereby paving the way for the development of more effective inhibitors.

These findings are the result of combining fundamental biological data using computational techniques.

<p>Aleix Prat (IDIBAPS), Roger Gomis (IRB Barcelona) and Juan Miguel Cejalvo (PhD student in the joint programme PhD4MD)</p>
20 Apr 2017

Researchers at IDIBAPS and IRB Barcelona have described in Cancer Research, that the longer the time from the onset of the tumour to the development of metastasis is, the more aggressive this cancer becomes.

<p>Left, atomic structure of RNA polymerase I in its inactive form - homodimer; Right, atomic structure of RNA polymerase I in its active form -heterodimer with Rrn3-. (Carlos Fernández-Tornero CIB/CSIC and Oriol Gallego, IRB Barcelona)</p>
16 Mar 2017

Researchers unveil a mechanism responsible for halting protein synthesis when cells are deprived of nutrients.

The cell regulates its growth by forming various assemblies of RNA polymerase I.

The study has implications for cancer research.