The web Hidden Nature has published an article about the 10 investigations that they considered to be the most important ones published in 2018. One of them refers to epigenetic therapies and mentions research research that supports and rejects them. In this regard, they mention the study led by Salvador Aznar Benitah at IRB Barcelona and published in Nature Cell Biology. The study in question concludes that care must be taken with drugs that inhibit epigenetic factors as they could cause the appearance of aggressive tumours.
Link to Hidden Nature