The video series Meet Our Scientists presents Travis Stracker, head of the Genomic Instability and Cancer lab at IRB Barcelona.
The video “Maintaining stability of the genome” highlights the research underway to unravel how cells prevent genomic instability.
The research performed by biologist Travis Stracker (Cleveland, OH, USA, 1974), head of the Genomic Instability and Cancer lab at IRB Barcelona, focuses on understanding of how cells prevent the accumulation of genomic instability.
This instability is caused by the accumulation of unrepaired mutations and errors in chromosomes. DNA damage occurs during each cell division or through exposure to exogenous agents, such as solar radiation, and chemical substances, such as tobacco smoke.
Stracker studies how cells prevent the accumulation of genomic instability by identifying the basic mechanisms that maintain the genome: “We have a genome consisting of millions of base pairs and it’s so delicate and susceptible: one mistake in the wrong place can have severe consequences.
In addition, his team studies how genomic instability influences cancer and rare diseases such as microcephaly. Stracker believes that his findings may be able to help provide patients with better treatments in the future.
Barcelona is a great place in which to do research, says the scientist, who is very happy to be living in a city that inspires creativity. In this regard, he thinks that there are parallels between music and science, saying “in both we have to work well as a team, depending on the individual talents of each of the group members, and we have to use creativity and improvisation in order to tackle challenging questions”.
Stracker shows the music tapes that his friends have given him over the years that reflect how far technology has progressed. “I look forward to seeing what the next 25 years bring in terms of technological development”, he says.
"Meet Our Scientists" is a series of short videos that presents the group leaders at IRB Barcelona. The videos seek to showcase the vision, passion, character and talent of the scientists working at the centre, as well as to disseminate biomedical research.
This video has been supported by the Spanish Foundation of Science and Technology (FECYT) and the Ministry of Economy and Competitiveness.
The newspapers Público and El Punt Avui,and the TV channel La Sexta, among other media, have reported on a recent study headed by Cayetano González, ICREA researcher at IRB Barcelona. Using the vinegar fly, Drosophila melanogaster, this study has identified possible regulators of the differences in tumours associated with the sex of an individual. Published in Science Advances, the study compares the brain tumours of male and female flies at the molecular level and identifies the protein responsible for the different degrees of aggressiveness.
An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments.
The study, published in Science Advances, compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness.
The radio station COPE, the newspaper ABC, RTVE and the scientific news agency SINC, among other media, have echoed news about a study led by Xavier Salvatella, head of the Molecular Biophysics Laboratory at IRB Barcelona. This study indicates that chaperone protein Hps70 could be an attractive therapeutic target for the treatment of Kennedy’s disease, a rare neuromuscular disorder, as well as castration-resistant prostate cancer.
