The radio station COPE, the newspaper ABC, RTVE and the scientific news agency SINC, among other media, have echoed news about a study led by Xavier Salvatella, head of the Molecular Biophysics Laboratory at IRB Barcelona. This study indicates that chaperone protein Hps70 could be an attractive therapeutic target for the treatment of Kennedy’s disease, a rare neuromuscular disorder, as well as castration-resistant prostate cancer.
Link to COPE
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Link to SINC
The newspapers Público and El Punt Avui,and the TV channel La Sexta, among other media, have reported on a recent study headed by Cayetano González, ICREA researcher at IRB Barcelona. Using the vinegar fly, Drosophila melanogaster, this study has identified possible regulators of the differences in tumours associated with the sex of an individual. Published in Science Advances, the study compares the brain tumours of male and female flies at the molecular level and identifies the protein responsible for the different degrees of aggressiveness.
An understanding of the molecular basis of differences in the incidence and survival of cancer between men and women may allow the discovery of specific and more effective treatments.
The study, published in Science Advances, compares the brain tumours of male and female flies at the molecular level and identifies proteins responsible for the different degree of aggressiveness.
Activation of the chaperone protein Hsp70 leads to a decrease in the formation of androgen receptor aggregates, which give rise to muscular atrophy in patients with Kennedy´s disease, a rare condition for which no treatment is available.
The results may also be useful in the search for a treatment for castration-resistant prostate cancer, a disease that causes 30,000 death a year in Europe and for which there is no treatment.
The study, which has been published in Nature Communications, is a collaboration with the University of California San Francisco and the University of Michigan.
