Research publications | IRB Barcelona

Title

Year

Research Group

Reduced mutation rate in exons due to differential mismatch repair

Frigola J; Sabarinathan R; Mularoni L; Muinõs F; Gonzalez-Perez A; López-Bigas N

Nature Genetics

1684 -

2017

Super-Resolution Microscopy Unveils Dynamic Heterogeneities in Nanoparticle Protein Corona

Feiner-Gracia N; Beck M; Pujals S; Tosi S; Mandal T; Buske C; Linden M; Albertazzi L

Small

1701631 -

1701631

2017

Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial

Coleman R; Hall A; Albanell J; Hanby A; Bell R; Cameron D; Dodwell D; Marshall H; Jean-Mairet J; Tercero JC; Rojo F; Gregory W; Gomis RR

Lancet Oncology

1543 -

1552

2017

Cancer stem cells revisited

Batlle E; Clevers H

Nature Medicine

1124 -

1134

2017

Differential requirements for Tousled-like kinases 1 and 2 in mammalian development

Segura-Bayona S; Knobel PA; Gonzalez-Buron H; Youssef SA; Peña-Blanco A; Coyaud E; Lopez-Rovira T; Rein K; Palenzuela L; Colombelli J; Forrow S; Raught B; Groth A; De Bruin A; Stracker TH

Cell Death And Differentiation

1872 -

1885

2017

Boundary Dpp promotes growth of medial and lateral regions of the Drosophila wing

Barrio L; Milán M

Elife

e22013

e22013 -

2017

Feedback amplification loop drives malignant growth in epithelial tissues

Muzzopappa M; Murcia L; Milán M

Proceedings Of The National Academy Of Sciences Of The United States Of America

114

E7291 -

E7300

2017

Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin

Bayona-Feliu A; Casas-Lamesa A; Reina O; Bernués J; Azorín F

Nature Communications

283 -

2017

Musashi 1 regulates the timing and extent of meiotic mRNA translational activation by promoting the use of specific CPEs

Weill L; Belloc E; Castellazzi CL; Méndez R

Nature Structural & Molecular Biology

672 -

2017

Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment

Testoni G; Duran J; García-Rocha M; Vilaplana F; Serrano A; Sebastián D; López-Soldado I; Sullivan M; Slebe F; Vilaseca M; Muñoz-Cánoves P; Guinovart J

Cell Metabolism

256 -

2017

A genome editing approach to study cancer stem cells in human tumors

Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E

Embo Molecular Medicine

869 -

879

2017

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E

Cell Stem Cell

801 -

2017

JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

Recasens-Alvarez C; Ferreira A; Milán M

Nature Communications

13815

13815 -

2017

Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Pluta, Radoslaw; Boer, D Roeland; Lorenzo-Diaz, Fabian; Russi, Silvia; Gomez, Hansel; Fernandez-Lopez, Cris; Perez-Luque, Rosa; Orozco, Modesto; Espinosa, Manuel; Coll, Miquel

Proceedings Of The National Academy Of Sciences Of The United States Of America

114

E6526 -

E6535

2017

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M

Cell Metabolism

1390 -

2017

Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar; Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul

Nature Cell Biology

94 -

105

2017

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA

Nature

541

7635

41 -

2017

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA

Nature

541

7635

41 -

2017

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T., Mayor-Ruiz C., Vega-Sendino M., Gomez C., Ortega S., Ruiz S. & Fernandez-Capetillo O.

PNAS

114

9367 -

9372

2017

TrapSeq: An RNA sequencing-based pipeline for the identification of genetrap insertions in mammalian cells

Mayor-Ruiz C., Dominguez O., Fernandez-Capetillo O

J Mol Bio

429

2780 -

2789

2017

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

Slebe F; Rojo F; Vinaixa M; García-Rocha M; Testoni G; Guiu M; Planet E; Samino S; Arenas E; Beltran A; Rovira A; Lluch A; Salvatella X; Yanes O; Albanell J; Guinovart J; Gomis R

Nature Communications

11199

11199 -

2016

Epigenetic control of adult stem cell function

Avgustinova A; Benitah S

Nature Reviews Molecular Cell Biology

643 -

658

2016

CPEB4 is regulated during cell cycle by ERK2/Cdk1-mediated phosphorylation and its assembly into liquid-like droplets

Guillén-Boixet J; Buzon V; Salvatella X; Méndez R

Elife

e19298

e19298 -

2016

Amino acid transport associated to cluster of differentiation 98 heavy chain (CD98HC) is at the cross-road of oxidative stress and amino acid availability

De La Ballina LR; Cano-Crespo S; González-Muñoz E; Bial S; Estrach S; Cailleteau L; Tissot F; Daniel H; Zorzano A; Ginsberg MH; Palacín M; Féral CC

Journal Of Biological Chemistry

291

9700 -

9711

2016

The N-Terminal Phosphorylation of RB by p38 Bypasses Its Inactivation by CDKs and Prevents Proliferation in Cancer Cells

Gubern A; Joaquin M; Marquès M; Maseres P; Garcia-Garcia J; Amat R; González-Nuñez D; Oliva B; Real F; de Nadal E; Posas F

Molecular Cell

25 -

2016

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

Becker D; Kaczmarska Z; Arkona C; Schulz R; Tauber C; Wolber G; Hilgenfeld R; Coll M; Rademann J

Nature Communications

12761

12761 -

2016

Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez MI; Serrano AL; Palacín M; Zorzano A

Embo Journal

1677 -

1693

2016

Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches

Izquierdo-Serra M; Bautista-Barrufet A; Trapero A; Garrido-Charles A; Diaz-Tahoces A; Camarero N; Pittolo S; Valbuena S; Perez-Jimenez A; Gay M; Garcia-Moll A; Rodriguez-Escrich C; Lerma J; De La Villa P; Fernandez E; Pericas M; Llebaria A; Gorostiza P

Nature Communications

12221

12221 -

2016

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

Sánchez-Huertas C; Freixo F; Viais R; Lacasa C; Soriano E; Lüders J

Nature Communications

12187

12187 -

2016

Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract

Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X

Biophysical Journal

110

2361 -

2366

2016

Nucleotide excision repair is impaired by binding of transcription factors to DNA

Sabarinathan R; Mularoni L; Deu-Pons J; Gonzalez-Perez A; Lopez-Bigas N

Nature

532

7598

264 -

267

2016

Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea

Djabrayan N; Casanova J

Plos Genetics

e1005909 -

2016

A feedback mechanism converts individual cell features into a supracellular ECM structure in drosophila trachea

Öztürk-Çolak A; Moussian B; Araújo SJ; Casanova J

Elife

FEBRUARY2016

2016

Developing Epithelia: What the Eye Cannot Grasp

Tosi, Sebastien; Milan, Marco

Developmental Cell

7 -

2016

Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis

Clemente-Ruiz, Marta; Murillo-Maldonado, Juan M; Benhra, Najate; Barrio, Lara; Perez, Lidia; Quiroga, Gonzalo; Nebreda, Angel R; Milan, Marco

Developmental Cell

290 -

302

2016

Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis

Rinaldi, Lorenzo; Datta, Debayan; Serrat, Judit; Morey, Lluis; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Ignacio Pons, Jose; Matallanas, David; Von Kriegsheim, Alex; Di Croce, Luciano; Aznar Benitah, Salvador

Cell Stem Cell

491 -

501

2016

Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry

Pittis, Alexandros A; Gabaldon, Toni

Nature

531

7592

101 -

2016

Saturation of recognition elements blocks evolution of new tRNA identities

Saint-Leger, Adelaide; Bello, Carla; Dans, Pablo D; Gabriel Torres, Adrian; Maria Novoa, Eva; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A; Ribas de Pouplana, Lluis

Science Advances

e1501860 -

2016

Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides

Salomó E, Orgué S, Riera A, Verdaguer X

Angewandte Chemie (International Ed. Print)

7988 -

7992

2016

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

De Mol E, Fenwick RB, Phang CT, Buzón V, Szulc E, de la Fuente A, Escobedo A, García J, Bertoncini CW, Estébanez-Perpiñá E, McEwan IJ, Riera A, Salvatella X

Acs Chemical Biology

2499 -

2505

2016

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Nagamori S; Wiriyasermkul P; Guarch M; Okuyama H; Nakagomi S; Tadagaki K; Nishinaka Y; Bodoy S; Takafuji K; Okuda S; Kurokawa J; Ohgaki R; Nunes V; Palacín M; Kanai Y

Proceedings Of The National Academy Of Sciences Of The United States Of America

113

775 -

780

2016

Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y, Nebreda AR

Nature Communications

11084

11084 -

2016

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease

Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R

Gastroenterology

150

982 -

2016

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Latorre-Pellicer A; Moreno-Loshuertos R; Lechuga-Vieco, AV

Nature

2016

BRD4 connects super enhancer remodeling to senescence immune surveillance

Tasdemir N*, Banito B*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CV, Lowe SW.
(*) these authors contributed equally

Cancer Discovery

2016

A genome- wide CRISPR screen identifies Cdc25A as a determinant of sensitivity to ATR inhibitors

Ruiz S. (#), Mayor-Ruiz C. (#), Lafarga V., Murga M., Vega-Sendino M., Ortega S., Fernandez-Capetillo O. ( # Equal contribution)

Mol Cell

307 -

313

2016

Designing alternative splicing RNA-seq studies. Beyond generic guidelines

Stephan-Otto Attolini C; Peña V; Rossell D

Bioinformatics

3631 -

3637

2015

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models

Huang Y; Skwarek-Maruszewska A; Horré K; Vandewyer E; Wolfs L; Snellinx A; Saito T; Radaelli E; Corthout N; Colombelli J; Lo AC; Van Aerschot L; Callaerts-Vegh Z; Trabzuni D; Bossers K; Verhaagen J; Ryten M; Munck S; D'Hooge R; Swaab DF; Hardy J; Saido TC; De Strooper B; Thathiah A

Science Translational Medicine

309

309ra164 -

2015