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Research

At the forefront of biomedicine

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Research publications

Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
Becker D; Kaczmarska Z; Arkona C; Schulz R; Tauber C; Wolber G; Hilgenfeld R; Coll M; Rademann J
7
12761
12761 -
2016
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez MI; Serrano AL; Palacín M; Zorzano A
35
15
1677 -
1693
2016
Optical control of endogenous receptors and cellular excitability using targeted covalent photoswitches
Izquierdo-Serra M; Bautista-Barrufet A; Trapero A; Garrido-Charles A; Diaz-Tahoces A; Camarero N; Pittolo S; Valbuena S; Perez-Jimenez A; Gay M; Garcia-Moll A; Rodriguez-Escrich C; Lerma J; De La Villa P; Fernandez E; Pericas M; Llebaria A; Gorostiza P
7
12221
12221 -
2016
Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
Sánchez-Huertas C; Freixo F; Viais R; Lacasa C; Soriano E; Lüders J
7
12187
12187 -
2016
Sequence Context Influences the Structure and Aggregation Behavior of a PolyQ Tract
Eftekharzadeh B; Piai A; Chiesa G; Mungianu D; García J; Pierattelli R; Felli I; Salvatella X
110
11
2361 -
2366
2016
Nucleotide excision repair is impaired by binding of transcription factors to DNA
Sabarinathan R; Mularoni L; Deu-Pons J; Gonzalez-Perez A; Lopez-Bigas N
532
7598
264 -
267
2016
Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea
Djabrayan N; Casanova J
12
3
e1005909 -
2016
A feedback mechanism converts individual cell features into a supracellular ECM structure in drosophila trachea
Öztürk-Çolak A; Moussian B; Araújo SJ; Casanova J
5
FEBRUARY2016
-
2016
Multiscale simulation of DNA
Dans P; Walther J; Gómez H; Orozco M
37
29 -
45
2016
Developing Epithelia: What the Eye Cannot Grasp
Tosi, Sebastien; Milan, Marco
36
1
7 -
8
2016
Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis
Clemente-Ruiz, Marta; Murillo-Maldonado, Juan M; Benhra, Najate; Barrio, Lara; Perez, Lidia; Quiroga, Gonzalo; Nebreda, Angel R; Milan, Marco
36
3
290 -
302
2016
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis
Rinaldi, Lorenzo; Datta, Debayan; Serrat, Judit; Morey, Lluis; Solanas, Guiomar; Avgustinova, Alexandra; Blanco, Enrique; Ignacio Pons, Jose; Matallanas, David; Von Kriegsheim, Alex; Di Croce, Luciano; Aznar Benitah, Salvador
19
4
491 -
501
2016
Late acquisition of mitochondria by a host with chimaeric prokaryotic ancestry
Pittis, Alexandros A; Gabaldon, Toni
531
7592
101 -
+
2016
Saturation of recognition elements blocks evolution of new tRNA identities
Saint-Leger, Adelaide; Bello, Carla; Dans, Pablo D; Gabriel Torres, Adrian; Maria Novoa, Eva; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A; Ribas de Pouplana, Lluis
2
4
e1501860 -
2016
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
Salomó E, Orgué S, Riera A, Verdaguer X
55
28
7988 -
7992
2016
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor
De Mol E, Fenwick RB, Phang CT, Buzón V, Szulc E, de la Fuente A, Escobedo A, García J, Bertoncini CW, Estébanez-Perpiñá E, McEwan IJ, Riera A, Salvatella X
11
9
2499 -
2505
2016
Parmbsc1: A refined force field for DNA simulations
Ivani I; Dans P; Noy A; Pérez A; Faustino I; Hospital A; Walther J; Andrio P; Goñi R; Balaceanu A; Portella G; Battistini F; Gelpí J; González C; Vendruscolo M; Laughton C; Harris S; Case D; Orozco M
13
1
55 -
+
2016
Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1
Nagamori S; Wiriyasermkul P; Guarch M; Okuyama H; Nakagomi S; Tadagaki K; Nishinaka Y; Bodoy S; Takafuji K; Okuda S; Kurokawa J; Ohgaki R; Nunes V; Palacín M; Kanai Y
113
3
775 -
780
2016
Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope
Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y, Nebreda AR
7
11084
11084 -
2016
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Angulo-Urarte A, Graupera M, Navarro P, Bosch J, Fernandez M, Mendez R
150
4
982 -
+
2016
BRD4 connects super enhancer remodeling to senescence immune surveillance
Tasdemir N*, Banito B*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CV, Lowe SW. *Co-first authors
2016
A genome- wide CRISPR screen identifies Cdc25A as a determinant of sensitivity to ATR inhibitors
Ruiz S. (#), Mayor-Ruiz C. (#), Lafarga V., Murga M., Vega-Sendino M., Ortega S., Fernandez-Capetillo O. ( # Equal contribution)
62
307 -
313
2016
Designing alternative splicing RNA-seq studies. Beyond generic guidelines
Stephan-Otto Attolini C; Peña V; Rossell D
31
22
3631 -
3637
2015
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models
Huang Y; Skwarek-Maruszewska A; Horré K; Vandewyer E; Wolfs L; Snellinx A; Saito T; Radaelli E; Corthout N; Colombelli J; Lo AC; Van Aerschot L; Callaerts-Vegh Z; Trabzuni D; Bossers K; Verhaagen J; Ryten M; Munck S; D'Hooge R; Swaab DF; Hardy J; Saido TC; De Strooper B; Thathiah A
7
309
309ra164 -
2015
Mitotic cell rounding and epithelial thinning regulate lumen growth and shape
Hoijman E; Rubbini D; Colombelli J; Alsina B
6
7355
7355 -
2015
Self-assembled trityl radical capsules -implications for dynamic nuclear polarization
Marin-Montesinos I; Paniagua J; Vilaseca M; Urtizberea A; Luis F; Feliz M; Lin F; Van Doorslaer S; Pons M
17
8
5785 -
5794
2015
Inntags: Small self-structured epitopes for innocuous protein tagging
Georgieva M; Yahya G; Codó L; Ortiz R; Teixidó L; Claros J; Jara R; Jara M; Iborra A; Gelpí J; Gallego C; Orozco M; Aldea M
12
10
955 -
958
2015
The stress kinase p38α as a target for cancer therapy
Igea A; Nebreda A
75
19
3997 -
4002
2015
SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer's disease: Appealing for ESI-IM-MS
Pujol-Pina R; Vilaprinyó-Pascual S; Mazzucato R; Arcella A; Vilaseca M; Orozco M; Carulla N
5
14809
14809 -
2015
Studying tumor growth in Drosophila using the tissue allograft method
Rossi F; Gonzalez C
10
10
1525 -
1534
2015
Dally proteoglycan mediates the autonomous and nonautonomous effects on tissue growth caused by activation of the PI3K and TOR pathways
Ferreira A; Milán M
13
8
e1002239 -
2015
Loss of Centrobin Enables Daughter Centrioles to Form Sensory Cilia in Drosophila
Gottardo M; Pollarolo G; Llamazares S; Reina J; Riparbelli M; Callaini G; Gonzalez C
25
17
2319 -
2324
2015
A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells
Campbell K; Casanova J
6
7998
7998 -
2015
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
Nadal-Ribelles M; Mas G; Millán-Zambrano G; Solé C; Ammerer G; Chávez S; Posas F; De Nadal E
43
10
4937 -
4949
2015
Inosine modifications in human tRNAs are incorporated at the precursor tRNA level
Torres A; Piñeyro D; Rodríguez-Escribà M; Camacho N; Reina O; Saint-Léger A; Filonava L; Batlle E; Ribas De Pouplana L
43
10
5145 -
5157
2015
Structural determinants of Smad function in TGF-β signaling
Macias M; Martin-Malpartida P; Massagué J
40
6
296 -
308
2015
DDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes
Kessler R; Tisserand J; Font-Burgada J; Reina O; Coch L; Attolini CSO; Garcia-Bassets I; Azorín F
6
7049
7049 -
2015
Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model
López-Soldado I; Zafra D; Duran J; Adrover A; Calbó J; Guinovart J
64
3
796 -
807
2015
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Calon A; Lonardo E; Berenguer-Llergo A; Espinet E; Hernando-Momblona X; Iglesias M; Sevillano M; Palomo-Ponce S; Tauriello D; Byrom D; Cortina C; Morral C; Barceló C; Tosi S; Riera A; Attolini C; Rossell D; Sancho E; Batlle E
47
4
320 -
U62
2015
In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities
Rubio-Perez C; Tamborero D; Schroeder M; Antolín A; Deu-Pons J; Perez-Llamas C; Mestres J; Gonzalez-Perez A; Lopez-Bigas N
27
3
382 -
396
2015
Visualizing phosphodiester-bond hydrolysis by an endonuclease
Molina R; Stella S; Redondo P; Gomez H; Marcaida MJ; Orozco M; Prieto J; Montoya G
22
1
65 -
72
2015
Structure and dynamics of oligonucleotides in the gas phase
Arcella A; Dreyer J; Ippoliti E; Ivani I; Portella G; Gabelica V; Carloni P; Orozco M
54
2
467 -
471
2015
Asymmetric intermolecular cobalt-catalyzed pauson-khand reaction using a p-stereogenic bis-phosphane
Orgué S; León T; Riera A; Verdaguer X
17
2
250 -
253
2015
QUIESCENCE Quantitative differences, qualitative outcomes
Pollarolo, Giulia; Gonzalez, Cayetano
3
e04869
-
2015
Decrease in Cell Volume Generates Contractile Forces Driving Dorsal Closure
Saias, Laure; Swoger, Jim; D'Angelo, Arturo; Hayes, Peran; Colombelli, Julien; Sharpe, James; Salbreux, Guillaume; Solon, Jerome
33
5
611 -
621
2015
Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis
Pavlovic, Milica; Arnal-Estape, Anna; Rojo, Federico; Bellmunt, Anna; Tarragona, Maria; Guiu, Marc; Planet, Evarist; Garcia-Albeniz, Xabier; Morales, Monica; Urosevic, Jelena; Gawrzak, Sylwia; Rovira, Ana; Prat, Aleix; Nonell, Lara; Lluch, Ana; Jean-Mairet, Joel; Coleman, Robert; Albanell, Joan; Gomis, Roger R
107
12
djv256 -
2015
Can A Denaturant Stabilize DNA? Pyridine Reverses DNA Denaturation in Acidic pH
Portella G; Terrazas M; Villegas N; González C; Orozco M
54
36
10488 -
10491
2015
The structural impact of DNA mismatches
Rossetti G; Dans P; Gomez-Pinto I; Ivani I; Gonzalez C; Orozco M
43
8
4309 -
4321
2015