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Research

At the forefront of biomedicine

Research publications

Mitotic cell rounding and epithelial thinning regulate lumen growth and shape
Hoijman E; Rubbini D; Colombelli J; Alsina B
Nature Communications
6
7355
7355 -
2015
Self-assembled trityl radical capsules -implications for dynamic nuclear polarization
Marin-Montesinos I; Paniagua J; Vilaseca M; Urtizberea A; Luis F; Feliz M; Lin F; Van Doorslaer S; Pons M
Physical Chemistry Chemical Physics
17
8
5785 -
5794
2015
The stress kinase p38α as a target for cancer therapy
Igea A; Nebreda A
Cancer Research
75
19
3997 -
4002
2015
SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer's disease: Appealing for ESI-IM-MS
Pujol-Pina R; Vilaprinyó-Pascual S; Mazzucato R; Arcella A; Vilaseca M; Orozco M; Carulla N
Scientific Reports
5
14809
14809 -
2015
Studying tumor growth in Drosophila using the tissue allograft method
Rossi F; Gonzalez C
Nature Protocols
10
10
1525 -
1534
2015
Dally proteoglycan mediates the autonomous and nonautonomous effects on tissue growth caused by activation of the PI3K and TOR pathways
Ferreira A; Milán M
Plos Biology
13
8
e1002239 -
2015
Loss of Centrobin Enables Daughter Centrioles to Form Sensory Cilia in Drosophila
Gottardo M; Pollarolo G; Llamazares S; Reina J; Riparbelli M; Callaini G; Gonzalez C
Current Biology
25
17
2319 -
2324
2015
A role for E-cadherin in ensuring cohesive migration of a heterogeneous population of non-epithelial cells
Campbell K; Casanova J
Nature Communications
6
7998
7998 -
2015
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
Nadal-Ribelles M; Mas G; Millán-Zambrano G; Solé C; Ammerer G; Chávez S; Posas F; De Nadal E
Nucleic Acids Research
43
10
4937 -
4949
2015
Inosine modifications in human tRNAs are incorporated at the precursor tRNA level
Torres A; Piñeyro D; Rodríguez-Escribà M; Camacho N; Reina O; Saint-Léger A; Filonava L; Batlle E; Ribas De Pouplana L
Nucleic Acids Research
43
10
5145 -
5157
2015
Structural determinants of Smad function in TGF-β signaling
Macias M; Martin-Malpartida P; Massagué J
Trends In Biochemical Sciences
40
6
296 -
308
2015
DDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes
Kessler R; Tisserand J; Font-Burgada J; Reina O; Coch L; Attolini CSO; Garcia-Bassets I; Azorín F
Nature Communications
6
7049
7049 -
2015
Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model
López-Soldado I; Zafra D; Duran J; Adrover A; Calbó J; Guinovart J
Diabetes
64
3
796 -
807
2015
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
Calon A; Lonardo E; Berenguer-Llergo A; Espinet E; Hernando-Momblona X; Iglesias M; Sevillano M; Palomo-Ponce S; Tauriello D; Byrom D; Cortina C; Morral C; Barceló C; Tosi S; Riera A; Attolini C; Rossell D; Sancho E; Batlle E
Nature Genetics
47
4
320 -
U62
2015
In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities
Rubio-Perez C; Tamborero D; Schroeder M; Antolín A; Deu-Pons J; Perez-Llamas C; Mestres J; Gonzalez-Perez A; Lopez-Bigas N
Cancer Cell
27
3
382 -
396
2015
Asymmetric intermolecular cobalt-catalyzed pauson-khand reaction using a p-stereogenic bis-phosphane
Orgué S; León T; Riera A; Verdaguer X
Organic Letters
17
2
250 -
253
2015
QUIESCENCE Quantitative differences, qualitative outcomes
Pollarolo, Giulia; Gonzalez, Cayetano
Elife
3
e04869
-
2015
Decrease in Cell Volume Generates Contractile Forces Driving Dorsal Closure
Saias, Laure; Swoger, Jim; D'Angelo, Arturo; Hayes, Peran; Colombelli, Julien; Sharpe, James; Salbreux, Guillaume; Solon, Jerome
Developmental Cell
33
5
611 -
621
2015
Enhanced MAF Oncogene Expression and Breast Cancer Bone Metastasis
Pavlovic, Milica; Arnal-Estape, Anna; Rojo, Federico; Bellmunt, Anna; Tarragona, Maria; Guiu, Marc; Planet, Evarist; Garcia-Albeniz, Xabier; Morales, Monica; Urosevic, Jelena; Gawrzak, Sylwia; Rovira, Ana; Prat, Aleix; Nonell, Lara; Lluch, Ana; Jean-Mairet, Joel; Coleman, Robert; Albanell, Joan; Gomis, Roger R
Jnci-Journal Of The National Cancer Institute
107
12
djv256 -
2015
Quantitative analysis of post-translational modifications in human serum transthyretin associated with familial amyloidotic polyneuropathy by targeted LC-MS and intact protein MS
Vilà-Rico M; Colomé-Calls N; Martín-Castel L; Gay M; Azorín S; Vilaseca M; Planas A; Canals F
Journal Of Proteomics
127
pt b
234 -
246
2015
Neutrophils support lung colonization of metastasis-initiating breast cancer cells
Wculek SK, Malanchi I#
(#) Corresponding author
Nature
528(7582):413-7
2015
Hyperactivated endolysosomal trafficking in melanoma
Alonso-Curbelo D, Soengas MS
Oncotarget
2015
RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development
Alonso-Curbelo D, Osterloh L, Cañón E, Calvo TG, Martínez-Herranz R, Karras P, Martínez S, et al, [corr. author] Soengas MS.
Oncotarget
2015
Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH
Urosevic, Jelena; Garcia-Albeniz, Xabier; Planet, Evarist; Real, Sebastian; Cespedes, Maria Virtudes; Guiu, Marc; Fernandez, Esther; Bellmunt, Anna; Gawrzak, Sylwia; Pavlovic, Milica; Mangues, Ramon; Dolado, Ignacio; Barriga, Francisco M; Nadal, Cristina; Kemeny, Nancy; Batlle, Eduard; Nebreda, Angel R; Gomis, Roger R
Nature Cell Biology
16
7
685 -
+
2014
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
Whissell, Gavin; Montagni, Elisa; Martinelli, Paola; Hernando-Momblona, Xavier; Sevillano, Marta; Jung, Peter; Cortina, Carme; Calon, Alexandre; Abuli, Anna; Castells, Antoni; Castellvi-Bel, Sergi; Nacht, Ana Silvina; Sancho, Elena; Stephan-Otto Attolini, Camille; Vicent, Guillermo P; Real, Francisco X; Batlle, Eduard
Nature Cell Biology
16
7
695 -
+
2014
Neurons have an active glycogen metabolism that contributes to tolerance to hypoxia
Saez, Isabel; Duran, Jordi; Sinadinos, Christopher; Beltran, Antoni; Yanes, Oscar; Tevy, Maria F; Martinez-Pons, Carlos; Milan, Marco; Guinovart, Joan J
Journal Of Cerebral Blood Flow And Metabolism
34
6
945 -
955
2014
Converging axons collectively initiate and maintain synaptic selectivity in a constantly remodeling sensory organ
Pujol-Martí J; Faucherre A; Aziz-Bose R; Asgharsharghi A; Colombelli J; Trapani J; López-Schier H
Current Biology
24
24
2968 -
74
2014
Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry
Slamnoiu S; Vlad C; Stumbaum M; Moise A; Lindner K; Engel N; Vilanova M; Diaz M; Karreman C; Leist M; Ciossek T; Hengerer B; Vilaseca M; Przybylski M
Journal Of The American Society For Mass Spectrometry
25
8
1472 -
1481
2014
Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function
Cuartero S; Fresán U; Reina O; Planet E; Espinàs M
Embo Journal
33
6
637 -
647
2014
Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements
Zhou R; Maisuradze G; Suñol D; Todorovski T; Macias M; Xiao Y; Scheraga H; Czaplewski C; Liwo A
Proceedings Of The National Academy Of Sciences Of The United States Of America
111
51
18243 -
18248
2014
The dynamics of microtubule minus ends in the human mitotic spindle
Lecland N; Lüders J
Nature Cell Biology
16
8
770 -
U248
2014
A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Afroz T; Skrisovska L; Belloc E; Guillén-Boixet J; Méndez R; Allain F
Genes & Development
28
13
1498 -
1514
2014
RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation
Morales M; Arenas EJ; Urosevic J; Guiu M; Fernández E; Planet E; Fenwick RB; Fernández-Ruiz S; Salvatella X; Reverter D; Carracedo A; Massagué J; Gomis RR
Embo Molecular Medicine
6
7
865 -
881
2014
Correlated motions are a fundamental property of β-sheets
Fenwick R; Orellana L; Esteban-Martín S; Orozco M; Salvatella X
Nature Communications
5
4070
4070 -
2014
Glycogen accumulation underlies neurodegeneration and autophagy impairment in lafora disease
Duran J; Gruart A; García-Rocha M; Delgado-García J; Guinovart J
Human Molecular Genetics
23
12
3147 -
3156
2014
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes
Sala D; Ivanova S; Plana N; Ribas V; Duran J; Bach D; Turkseven S; Laville M; Vidal H; Karczewska-Kupczewska M; Kowalska I; Straczkowski M; Testar X; Palacín M; Sandri M; Serrano AL; Zorzano A
Journal Of Clinical Investigation
124
5
1914 -
1927
2014
Dual Function of p38α MAPK in Colon Cancer: Suppression of Colitis-Associated Tumor Initiation but Requirement for Cancer Cell Survival
Gupta J; delBarcoBarrantes I; Igea A; Sakellariou S; Pateras I; Gorgoulis V; Nebreda A
Cancer Cell
25
4
484 -
500
2014
Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc
Rosell A; Meury M; A?varez-Marimon E; Costa M; Pe?ez-Cano L; Zorzano A; Ferna?dez-Recio J; Palaci? M; Fotiadis D
Proceedings Of The National Academy Of Sciences Of The United States Of America
111
8
2966 -
2971
2014
Metastatic stem cells: Sources, niches, and vital pathways
Oskarsson T; Batlle E; Massagué J
Cell Stem Cell
14
3
306 -
321
2014
ChroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome
Font-Burgada J; Reina O; Rossell D; Azorín F
Nucleic Acids Research
42
4
2126 -
2137
2014
Control of Cdc28 CDK1 by a Stress-Induced lncRNA
Nadal-Ribelles M; Solé C; Xu Z; Steinmetz LM; deNadal E; Posas F
Molecular Cell
53
4
549 -
561
2014
Thread insertion of a bis(dipyridophenazine) diruthenium complex into the DNA double helix by the extrusion of at base pairs and cross-linking of DNA duplexes
Boer D; Wu L; Lincoln P; Coll M
Angewandte Chemie (International Ed. Print)
53
7
1949 -
1952
2014
Structural basis for DNA binding specificity by the auxin-dependent ARF transcription factors
Boer D; Freire-Rios A; Van Den Berg W; Saaki T; Manfield I; Kepinski S; López-Vidrieo I; Franco-Zorrilla J; De Vries S; Solano R; Weijers D; Coll M
Cell
156
3
577 -
589
2014
Specification of leading and trailing cell features during collective migration in the Drosophila trachea
Lebreton G; Casanova J
Journal Of Cell Science
127
2
465 -
474
2014
MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation
Barrio, Lara; Dekanty, Andres; Milan, Marco
Cell Reports
8
2
527 -
540
2014
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo
Maria Novoa, Eva; Camacho, Noelia; Tor, Anna; Wilkinson, Barrie; Moss, Steven; Marin-Garcia, Patricia; Azcarate, Isabel G; Bautista, Jose M; Mirando, Adam C; Francklyn, Christopher S; Varon, Sonia; Royo, Miriam; Cortes, Alfred; Ribas de Pouplana, Lluis
Proceedings Of The National Academy Of Sciences Of The United States Of America
111
51
E5508 -
E5517
2014
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway
Alonso-Curbelo D, Riveiro-Falkenbach E, Pérez-Guijarro E, Cifdaloz M, Karras P, Osterloh L, Megías D, Cañón E, et al, [corr. author] Soengas MS.
Cancer Cell
2014
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity
Winter G.E., Radic B. (#), Mayor-Ruiz C. (#), Blomen V.A., Trefzer C., Kandasamy R.K., Huber K.V.M., Gridling M., Chen D., Klampfl T., Kralovics R., Kubicek S., Fernandez-Capetillo O., Brummelkamp T.R., Superti-Furga G. (# Equal contribution)
Nat Chem Bio
10
768 -
773
2014