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Structural Characterization of Macromolecular Assemblies News

Scientific
A new inactive form of p38a protein discovered
Media mentions
Descrito el mecanismo de acción de un importante factor de transcripción - BioTech
Scientific
Researchers uncover the mechanism of action of an important transcription factor
Scientific
Scientists disclose the mechanism of action of solnatide, a possible treatment for pulmonary edema
Family of structural conformers in solution determined by NMR (above). Detail of the key contacts between amino acids (in yellow) that define the characteristics of the active analogue.
Scientific
Towards a new treatment for Crohn's disease and ulcerative colitis
The SMAD2 protein can have two orientations. Green indicates the open configuration that allows DNA binding and red the closed configuration, which is incompatible with such binding. Maria J. Macias, IRB Barcelona.
Scientific
Scientists decipher the keys underlying the differences between SMAD2 and SMAD3, two almost identical transcription factors but with distinct roles
Photos of the presentation ceremony of the awards given by the Fundació La Marató
Institutional
La Marató awards six projects that involve IRB Barcelona
Structure of TGIF1, attached to DNA.
Scientific
Researchers discover a mechanism that inhibits the Smad signalling pathway
Maria Macias, group leader of the Structural Characterization of Macromolecular Assemblies Lab
Media mentions
Women in senior positions, is it easy for them? Interview with Maria Macias
Image shows the interaction between the MH1 domain of Smad4 in complex with the GGCGC site (Maria Macias, IRB Barcelona)
Scientific
Understanding the adaptability of Smads
Image: Maria Macias
Media mentions
Maria Macias’s most recent study selected as the article of the month by the Spanish Biophysical Society
Representation of a Smad protein 3D structure. In red, the most common mutations in lung cancer (M. Macias lab, IRB Barcelona)
Institutional
Structural biologists endorse the potential of their field to extract quality information from “big data”
Institutional
Maria Macias: “Structural biologists are as meticulous as watchmakers”
Structural details of the MH2 domains of Smad2 and 4 , with mutations, shown in orange, found in lung tumours.
Innovation
“3D” review on Smads
irbbarcelona
Media mentions
Artisans of pharmaceutical agents
Structure of the somatostatina analogue synthesized in Riera's Lab
Scientific
Better than the natural hormone
Media mentions
Discovery of a new mechanism of gene control that is associated with cancer
Smad region (in blue) bound to the protein that causes its degradation after gene activation (in gray).
Scientific
Discovery of a new mechanism of gene control that is associated with cancer
irbbarcelona
Institutional
IRB Barcelona scientists join forces in a Consolider project in molecular oncology
Interaction between the ubiquitin ligase (larger molecule) and the LMP2A membrane protein sequence (blue line). <br />
Scientific
Researchers at IRB Barcelona discover a possible escape route from destruction of defective proteins and the Epstein Barr virus