Cell and Developmental BiologyDevelopment and Growth Control Laboratory

Development and Growth Control Laboratory
Group Leader

ICREA Research Professor

+34 93 40 34902

We are interested in the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, tissue homeostasis and tumorigenesis. We perform these studies in Drosophila melanogaster, because of its suitability for genetic and molecular manipulations and its well-described developmental biology. Our current work focuses on the following topics:

Growth control during normal development: The wing primordium is a monolayered epithelial sac that grows one-thousand folds in size and number of cells to give rise to the adult wing. It is subdivided into compartments, cell populations that do not mix during the proliferative stages, and interactions between these compartments induce the expression or activity of signaling molecules that organize growth and pattern formation. We are interested in understanding the molecular mechanisms that organize and coordinate growth and patterning, the gene regulatory networks involved in compartment boundary formation and the cellular mechanisms involved in generating the affinity barriers.

Coordination of tissue growth: In multi-cellular organisms, coordination of growth between and within organs contributes to the generation of well proportioned organs and functionally integrated adults and ensures adaptation to environmental conditions. We are currently analyzing the molecular mechanisms involved in these processes, with a particular interest on the role of Drosophila p53 and the micro-RNA machinery.

Drosophila epithelial cells as a model for cancer biology: Wing primordia have provided useful as model systems to elucidate the molecular mechanisms underlying tumorigenic growth. We are interested in identifying the cellular and molecular mechanisms that lead to oncogene-mediated hyperplasic growth, cell delamination, basement membrane degradation and host invasiveness.

Clemente-Ruiz M, Murillo-Maldonado JM, Benhra N, Barrio L, Pérez L, Quiroga G, Nebreda AR and Milán M.
Dev Cell, 36 (3), 290-302 (2016)
Boulan L, Martín D and Milán M.
Curr Biol, 23 (6), 473-8 (2013)
Dekanty A, Barrio L, Muzzopappa M, Auer H, and Milán M
P Natl Acad Sci Usa, 109 (50), 20549-54 (2012)
Duran J, Tevy MF, Garcia-Rocha M, Calbó J, Milán M* and Guinovart JJ*.
EMBO Mol Med, 4 (8), 719-29 (2012)
Mesquita D, Dekanty A and Milán M.
Plos Biol, 8 (12), e1000566 (2010)
Becam I, Fiuza UM, Arias AM and Milán M.
Curr Biol, 20 (6), 554-60 (2010)
Herranz H, Hong X, Pérez L, Ferreira A, Olivieri D, Cohen SM and Milán M.
Embo J, 29 (10), 1688-98 (2010)
Herranz H, Pérez L, Martín FA and Milán M.
Embo J, 27 (11), 1633-45 (2008)

* shared senior authorship

This group receives financial support from the following sources:

  • Ministerio de Educación y Ciencia (Spanish Ministry of Science and Education)
  • Generalitat de Catalunya (DURSI)(Government of Catalonia)
  • ICREA (Catalan Institute of Research and Advanced Studies)
  • EMBO Young Investigator Programme
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

<p>The "Create your own monster" workshops aims to teach children about the genetic code</p>
14 Jun 2016

This weekend, 18 and 19 June, Ciutadella Park will be turned into a science exhibition for public of all ages.

<p>In the picture, precursor cells of fly wing tissue, labelled for various proteins. This fly model has been used to perform experiments addressing the relationship between chromosome instability, aneuploidy, and tumorigenesis (Lara Barrio, IRB Barcelona)</p>
9 Feb 2016

A recent analysis of 43,205 human tumours unveiled that 68% of solid tumours are aneuploid, that is to say, they have an altered number of chromosomes.

12 Jan 2016

Diari de Girona has published a column on a new mechanism involved in tissue regeneration, discovered recently.

Upcoming events

03 Oct - 05 Oct
Institut d'Estudis Catalans (IEC), Barcelona
05 Oct
Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Brad Stith, University of Colorado Denver
06 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Prof. Graham Ellis-Davies, Department of Neuroscience, Mount Sinai School of Medicine, NY (USA)