Cell and Developmental BiologyDevelopment and morphogenesis in Drosophila

Development and morphogenesis in Drosophila
Group Leader

Professor (IBMB-CSIC)

+34 93 40 34967

Studies on the genetic control of development have proven to be very been fruitful in unveiling the mechanisms impaired in many disease conditions. This is particularly true in the case of cancer and associated illnesses, as can be assessed by the wealth of knowledge obtained from the study of the developmental role of oncogenes and tumour suppressor genes, the studies of cell migration, epithelial-mesenchymal transition and vasculogenesis. In this regard, the focus of our research at the IRB is to advance in providing basic knowledge on the genetic regulation of such developmental processes, and in particular in their control by cell communication mechanisms. Our aim is to study those phenomena in the context of the whole organism and to do so we use Drosophila melanogaster as a tool. The choice of Drosophila as a model system to study the basic phenomena in development has proved to be extremely fruitful. The broad conservation of the developmental key genes identified in Drosophila and the basic similarity between developmental processes in different species justifies the choice of an organism as a model system.

The work of many laboratories has allowed to begin to understand the genetics logic behind development and we are now trying to understand how these mechanisms impinge on cell behaviour. In particular, we put our emphasis on the issue of the supracellular organisation and more precisely on how individual cell changes can generate an upper level of complexity such the one found in tissues and organs. We work in this research field using two Drosophila models already well known in the lab (the transduction pathway specifying the embryonic terminal regions and the tracheal system), as well as another one more recently added (the morphogenesis of the endoderm and gut). We hope that a global approach using these three systems will allow us unveil how transcription factors and signalling pathways trigger and coordinate changes in cell issues such as shape, polarity and adhesion into collective organization and migration. In performing this global approach we also consider an evolutionary perspective that could account for the recruitment of already existing mechanisms into distinct processes or for their particular redeployment to explain appearance of different kinds of supracellular organization. Finally, we hope this approach will be also crucial to provide an understanding of some of the mechanisms involved in disease conditions and in particular in oncogenesis. To this aim, we have fostered our collaboration with some research groups from the oncology programme.

  • Analysis of the mechanisms responsible for the localized activation of the Torso receptor tyrosine kinase.
  • Analysis of gene expression regulation by the Torso transduction pathway, especially in relation with the inactivation of the capicua repressor.
  • Analysis of cell adhesion and cytoskeleton regulation during migration and tube formation in the tracheal system.
  • Properties of the collective cell migration.
  • The role of GATA factors in the endoderm epithelial-to-mese.nchymal transition (EMT).
Öztürk-Çolak A, Moussian B, Araújo SJ and Casanova J.
Elife, 5 (2016)
Djabrayan NJ, Cruz J, de Miguel C, Franch-Marro X and Casanova J.
Cell Rep, 9 (3), 859-865 (2014)
Casanova J.
Embo Rep, 13 (5), 396-7 (2012)
Campbell K, Whissell G, Franch-Marro X, Batlle E and Casanova J.
Dev Cell, 21 (6), 1051-61 (2011)
Brodu V, Baffet AD, Le Droguen PM, Casanova J* and Guichet A*.
Dev Cell, 18 (5), 790-801 (2010)
Gervais L and Casanova J.
Curr Biol, 20 (4), 359-66 (2010)
Shaye DD, Casanova J* and Llimargas M*.
Nat Cell Biol, 10 (8), 964-70 (2008)

* shared senior authorship

This groups is financially supported by:

  • Ministerio de Educación y Ciencia (MEC - Spanish Ministry of  Science & Education)

Group news & mentions

<p>In August, IRB Barcelona scientists published two studies devoted to circadian rhythm, aging and diet in the journal Cell.</p>
5 Oct 2017

The prize is shared between American scientists Jeffrey C Hall, Michael Rosbash and Michael W Young for work on the internal clock of living organisms, using the f

<p>Teachers and scientists working together.</p>
17 Mar 2017

On 17 and 18 March, fifteen secondary school teachers from around Catalonia will have the opportunity to learn about the fruit fly Drosophila melanogaster, an animal model used to study de

10 Oct 2016

On the occasion of the Barcelona Biomed

3 Oct 2016

How do paediatric cancers differ from those in adults? What makes a static cell migrate and promote metastasis? How do differentiated cells become tissue repair cells?

Upcoming events

25 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
Daniel Fisher. Centre national de la Recherche Scientifique(CNRS) Institute of Molecular Genetics (IGMM)
25 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
Jody Rosenblatt, Ph.D. H. A. and Edna Benning Presidential Endowed Chair HHMI. Faculty Scholar Professor Huntsman Cancer Institute. Department of Oncological Sciences University of Utah
26 Oct
IRB Meeting Room 1 – IRB Administration Building, 1st Floor
Speaker: Alba Olivares, Technology Transfer Officer at IRB Barcelona