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Research

At the forefront of biomedicine

Research publications

Dependency of Colorectal Cancer on a TGF-beta-Driven Program in Stromal Cells for Metastasis Initiation
Calon, A; Espinet, E; Palomo-Ponce, S; Tauriello, DVF; Iglesias, M; Céspedes, MV; Sevillano, M; Nadal, C; Jung, P; Zhang, XHF; Byrom, D; Riera, A; Rossell, D; Mangues, R; Massagué, J; Sancho, E; Batlle, E
Cancer Cell
22
5
571 -
584
2012
Pten positively regulates brown adipose function, energy expenditure, and longevity
Muñoz Martin, Maria Angeles; Ortega-Molina, Ana; Efeyan, Alejo; Lopez-Guadamillas, Elena; Munoz-Martin, Maribel; Gomez-Lopez, Gonzalo; Canamero, Marta; Mulero, Francisca; Pastor, Joaquin; Martinez, Sonia; Romanos, Eduardo; Mar Gonzalez-Barroso, M; Rial, Eduardo; Valverde, Angela M; Bischoff, James R; Serrano, Manuel
Cell Metabolism
15
3
382 -
394
2012
Key contribution of CPEB4-mediated translational control to cancer progression
Ortiz-Zapater, E; Pineda, D; Martínez-Bosch, N; Fernández-Miranda, G; Iglesias, M; Alameda, F; Moreno, M; Eliscovich, C; Eyras, E; Real, FX; Méndez, R; Navarro, P
Nature Medicine
18
1
83 -
90
2012
The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress
Joaquin M; Gubern A; González-Nuñez D; Josué Ruiz E; Ferreiro I; De Nadal E; Nebreda A; Posas F
Embo Journal
31
13
2952 -
2964
2012
Deleterious effects of neuronal accumulation of glycogen in flies and mice
Duran, J; Tevy, MF; Garcia-Rocha, M; Calbó, J; Milán, M; Guinovart, JJ
Embo Molecular Medicine
4
8
719 -
729
2012
Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia
Dekanty, A; Barrio, L; Muzzopappa, M; Auer, H; Milán, M
Proceedings Of The National Academy Of Sciences Of The United States Of America
109
50
20549 -
20554
2012
A Role for tRNA Modifications in Genome Structure and Codon Usage
Novoa, EM; Pavon-Eternod, M; Pan, T; de Pouplana, LR
Cell
149
1
202 -
213
2012
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián, D; Hernández-Alvarez, MI; Segalés, J; Sorianello, E; Muñoz, JP; Sala, D; Waget, A; Liesa, M; Paz, JC; Gopalacharyulu, P; Oresic, M; Pich, S; Burcelin, R; Palacín, M; Zorzano, A
Proceedings Of The National Academy Of Sciences Of The United States Of America
109
14
5523 -
5528
2012
P-Stereogenic Secondary Iminophosphorane Ligands and Their Rhodium(I) Complexes: Taking Advantage of NH/PH Tautomerism
León, T; Parera, M; Roglans, A; Riera, A; Verdaguer, X
Angewandte Chemie (International Ed. Print)
51
28
6951 -
6955
2012
Fine-tuning the p-p Aromatic Interactions in Peptides: Somatostatin Analogues Containing Mesityl Alanine
Martín-Gago, P; Gomez-Caminals, M; Ramón, R; Verdaguer, X; Martin-Malpartida, P; Aragón, E; Fernández-Carneado, J; Ponsati, B; López-Ruiz, P; Cortes, MA; Colás, B; Macias, MJ; Riera, A
Angewandte Chemie (International Ed. Print)
51
8
1820 -
1825
2012
Drosophila melanogaster linker histone dH1 is required for transposon silencing and to preserve genome integrity
Vujatovic, O; Zaragoza, K; Vaquero, A; Reina, O; Bernués, J; Azorín, F
Nucleic Acids Research
40
12
5402 -
5414
2012
Isolation and in vitro expansion of human colonic stem cells
Jung, P; Sato, T; Merlos-Suárez, A; Barriga, FM; Iglesias, M; Rossell, D; Auer, H; Gallardo, M; Blasco, MA; Sancho, E; Clevers, H; Batlle, E
Nature Medicine
17
10
1225 -
1227
2011
Specific GATA Factors Act as Conserved Inducers of an Endodermal-EMT
Campbell, K; Whissell, G; Franch-Marro, X; Batlle, E; Casanova, J
Developmental Cell
21
6
1051 -
1061
2011
Controlling gene expression in response to stress
De Nadal E; Ammerer G; Posas F
Nature Reviews Genetics
12
12
833 -
845
2011
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter
Rubio-Cosials, A; Sidow, JF; Jiménez-Menéndez, N; Fernández-Millán, P; Montoya, J; Jacobs, HT; Coll, M; Bernadó, P; Solà, M
Nature Structural & Molecular Biology
18
11
1281 -
U133
2011
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress
Solé C; Nadal-Ribelles M; Kraft C; Peter M; Posas F; De Nadal E
Embo Journal
30
16
3274 -
3284
2011
Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease
Valles-Ortega, J; Duran, J; Garcia-Rocha, M; Bosch, C; Saez, I; Pujadas, L; Serafin, A; Cañas, X; Soriano, E; Delgado-García, JM; Gruart, A; Guinovart, JJ
Embo Molecular Medicine
3
11
667 -
681
2011
The F box protein partner of paired regulates stability of drosophila centromeric histone H3, CenH3 CID
Moreno-Moreno, O; Medina-Giró, S; Torras-Llort, M; Azorín, F
Current Biology
21
17
1488 -
1493
2011
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
Solanas, G; Cortina, C; Sevillano, M; Batlle, E
Nature Cell Biology
13
9
1100 -
U128
2011
Drosophila neuroblasts retain the daughter centrosome
Januschke, J; Llamazares, S; Reina, J; Gonzalez, C
Nature Communications
2
243 -
2011
Distributed biological computation with multicellular engineered networks
Regot S; MacIa J; Conde N; Furukawa K; Kjellén J; Peeters T; Hohmann S; De Nadal E; Posas F; Solé R
Nature
469
7329
207 -
211
2011
The structure of a transcription activation subcomplex reveals how sigma(70) is recruited to PhoB promoters
Blanco, AG; Canals, A; Bernués, J; Solà, M; Coll, M
Embo Journal
30
18
3776 -
3785
2011
The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
Merlos-Suárez, A; Barriga, FM; Jung, P; Iglesias, M; Céspedes, MV; Rossell, D; Sevillano, M; Hernando-Momblona, X; da Silva-Diz, V; Muñoz, P; Clevers, H; Sancho, E; Mangues, R; Batlle, E
Cell Stem Cell
8
5
511 -
524
2011
DDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling
Francis, VA; Zorzano, A; Teleman, AA
Current Biology
20
20
1799 -
1808
2010
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1α/mitofusin-2 regulatory pathway in response to physical activity
Hernández-Alvarez, MI; Thabit, H; Burns, N; Shah, S; Brema, I; Hatunic, M; Finucane, F; Liesa, M; Chiellini, C; Naon, D; Zorzano, A; Nolan, JJ
Diabetes Care
33
3
645 -
651
2010
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila
Janic, A; Mendizabal, L; Llamazares, S; Rossell, D; Gonzalez, C
Science
330
6012
1824 -
1827
2010
A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila
Mesquita, D; Dekanty, A; Milán, M
Plos Biology
8
12
e1000566 -
2010
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat
Jiménez-Menéndez, N; Fernández-Millán, P; Rubio-Cosials, A; Arnan, C; Montoya, J; Jacobs, HT; Bernadó, P; Coll, M; Usón, I; Solà, M
Nature Structural & Molecular Biology
17
7
891 -
893
2010
The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing
Herranz, H; Hong, X; Pérez, L; Ferreira, A; Olivieri, D; Cohen, SM; Milán, M
Embo Journal
29
10
1688 -
1698
2010
Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control
Novoa, I; Gallego, J; Ferreira, PG; Mendez, R
Nature Cell Biology
12
5
447 -
U82
2010
A Role of Receptor Notch in Ligand cis-Inhibition in Drosophila
Becam, I; Fiuza, UM; Arias, AM; Milán, M
Current Biology
20
6
554 -
560
2010
Chimeric tRNAs as tools to induce proteome damage and identify components of stress responses
Geslain, R; Cubells, L; Bori-Sanz, T; Alvarez-Medina, R; Rossell, D; Martí, E; de Pouplana, LR
Nucleic Acids Research
38
5
e30 -
2010
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain
Nadal, M; Mas, PJ; Blanco, AG; Arnan, C; Solà, M; Hart, DJ; Coll, M
Proceedings Of The National Academy Of Sciences Of The United States Of America
107
37
16078 -
16083
2010
Self-killing of melanoma cells by cytosolic delivery of dsRNA: Wiring innate immunity for a coordinated mobilization of endosomes, autophagosomes and the apoptotic machinery in tumor cells
Alonso-Curbelo D, Soengas MS
Autophagy
2010
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Li, Han; Collado, Manuel; Villasante, Aranzazu; Strati, Katerina; Ortega, Sagrario; Canamero, Marta; Blasco, Maria A; Serrano, Manuel
Nature
460
7259
1136 -
U101
2009
Focus on the centre: The role of chromatin on the regulation of centromere identity and function
Torras-Llort, M; Moreno-Moreno, O; Azorín, F
Embo Journal
28
16
2337 -
2348
2009
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells
Tormo D, Checińska A, Alonso-Curbelo D, Pérez-Guijarro E, Cañón E, Riveiro-Falkenbach E, Calvo TG, Larribere L, et al, [corr. author] Soengas MS.
Cancer Cell
2009
An Operational RNA Code for Faithful Assignment of AUG Triplets to Methionine
Jones, TE; Brown, CL; Geslain, R; Alexander, RW; De Pouplana, LR
Molecular Cell
29
3
401 -
407
2008
Drosophila HP1c isoform interacts with the zinc-finger proteins WOC and Relative-of-WOC to regulate gene expression
Font-Burgada, J; Rossell, D; Auer, H; Azorín, F
Genes & Development
22
21
3007 -
3023
2008
Spindle-localized CPE-mediated translation controls meiotic chromosome segregation
Eliscovich, C; Peset, I; Vernos, I; Méndez, R
Nature Cell Biology
10
7
858 -
865
2008
A deadenylation negative feedback mechanism governs meiotic metaphase arrest
Belloc, E; Méndez, R
Nature
452
7190
1017 -
U11
2008
The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching
Aguilar-Arnal, L; Marsellach, FX; Azorín, F
Embo Journal
27
7
1029 -
1038
2008
A Combinatorial Code for CPE-Mediated Translational Control
Piqué, M; López, JM; Foissac, S; Guigó, R; Méndez, R
Cell
132
3
434 -
448
2008
A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing.
Herranz, H; Pérez, L; Martín, FA; Milán, M
Embo Journal
27
11
1633 -
1645
2008
Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
Vilchez, D; Ros, S; Cifuentes, D; Pujadas, L; Vallès, J; García-Fojeda, B; Criado-García, O; Fernández-Sánchez, E; Medraño-Fernández, I; Domínguez, J; García-Rocha, M; Soriano, E; De Córdoba, SR; Guinovart, JJ
Nature Neuroscience
10
11
1407 -
1413
2007
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Caussinus E; Gonzalez C
Nature Genetics
37
10
1125 -
1129
2005