Biostatistics/Bioinformatics

Dr. Camille Stephan-Otto Attolini

Core Facility Manager

Telephone:

+34 93 40 20217

Email:

camille.stephan@irbbarcelona.org

Meet Our Scientists Videos

Camille Stephan-Otto: "Deciphering the bytes of life"

Research information

Background

The mission of the Biostatistics/Bioinformatics Unit is to conduct collaborative research and to provide consultation and quantitative research resources to all IRB Barcelona research groups.

We assist scientists by providing both short and long-term consultancy services in the following areas:

Experimental design: sample size, study design, planning of statistical methodology
Data analysis: clinical or biomedical databases, genomics data
Assistance with statistical methodology in own or others’ research
Software: help in using software, develop software to meet special data analysis or study design needs

The facility conducts methodological research and develops resources in all of the above-mentioned areas.

For more information contact the manager of the Biostatistics/Bioinformatics Unit at
camille.stephan arroba irbbarcelona.org.

Selected publications

A genome editing approach to study cancer stem cells in human tumors

Cortina C; Turon G; Stork D; Hernando-Momblona X; Sevillano M; Aguilera M; Tosi S; Merlos-Suárez A; Stephan-Otto Attolini C; Sancho E; Batlle E

Embo Molecular Medicine

(7 )

869 -

879

(2017)

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

Barriga F; Montagni E; Mana M; Mendez-Lago M; Hernando-Momblona X; Sevillano M; Guillaumet-Adkins A; Rodriguez-Esteban G; Buczacki S; Gut M; Heyn H; Winton D; Yilmaz O; Attolini C; Gut I; Batlle E

Cell Stem Cell

(6 )

801 -

(2017)

Targeting metastasis-initiating cells through the fatty acid receptor CD36.

Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L, Benitah SA

Nature

541

(7635 )

41 -

(2017)

Designing alternative splicing RNA-seq studies. Beyond generic guidelines

Stephan-Otto Attolini C; Peña V; Rossell D

Bioinformatics

(22 )

3631 -

3637

(2015)

Inosine modifications in human tRNAs are incorporated at the precursor tRNA level

Torres A; Piñeyro D; Rodríguez-Escribà M; Camacho N; Reina O; Saint-Léger A; Filonava L; Batlle E; Ribas De Pouplana L

Nucleic Acids Research

(10 )

5145 -

5157

(2015)

DDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes

Kessler R; Tisserand J; Font-Burgada J; Reina O; Coch L; Attolini CSO; Garcia-Bassets I; Azorín F

Nature Communications

(7049 )

7049 -

(2015)

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Calon A; Lonardo E; Berenguer-Llergo A; Espinet E; Hernando-Momblona X; Iglesias M; Sevillano M; Palomo-Ponce S; Tauriello D; Byrom D; Cortina C; Morral C; Barceló C; Tosi S; Riera A; Attolini C; Rossell D; Sancho E; Batlle E

Nature Genetics

(4 )

320 -

329

(2015)

The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression

Whissell, Gavin; Montagni, Elisa; Martinelli, Paola; Hernando-Momblona, Xavier; Sevillano, Marta; Jung, Peter; Cortina, Carme; Calon, Alexandre; Abuli, Anna; Castells, Antoni; Castellvi-Bel, Sergi; Nacht, Ana Silvina; Sancho, Elena; Stephan-Otto Attolini, Camille; Vicent, Guillermo P; Real, Francisco X; Batlle, Eduard

Nature Cell Biology

(7 )

695 -

707

(2014)

Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function

Cuartero S; Fresán U; Reina O; Planet E; Espinàs M

Embo Journal

(6 )

637 -

647

(2014)

ChroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome

Font-Burgada J; Reina O; Rossell D; Azorín F

Nucleic Acids Research

(4 )

2126 -

2137

(2014)

htSeqTools: High-throughput sequencing quality control, processing and visualization in R

Planet E; Attolini C; Reina O; Flores O; Rossell D

Bioinformatics

(4 )

589 -

590

(2012)

Services

Microarrays: Quality control, Differential expression, Enrichment analysis of GO and KEGG, GSEA GO and KEGG, Signature discovery
RNASeq: Quality control, Differential expression, Enrichment analysis of GO and KEGG, Signature discovery, Isoform switching, SNP calling
ChipSeq: Processing, Quality control, Peak definition + annotation + visualization, Differential Binding + Integrative analysis
Whole Genome Sequencing: Processing, Quality control, SNP calling, Copy number alteration calling
Whole Exome Sequencing: Processing, Quality control, SNP calling, Copy number alteration calling
Proteomics: Processing, Quality control, Differential expression, Enrichment analysis of GO and KEGG
Public database mining and analysis: Selection, Curation of clinical data, Processing of expression data, Association of expression and clinical data, Integration of copy number/genomic data
TCGA analysis: Exploratory analysis in all cancer types: association between expression and clinical variables, Detailed analysis with curated clinical and technical variables: association with expression, Data integration: copy number, expression, mutations, etc
Microbiome: Quality control + OTU estimation + differential abundance, Phylogenetic analysis
Binding prediction: Prediction of binding to RNA/DNA by proteins/genes
Single Cell Sequencing: Processing, Quality control, Differential expression, Clustering, Trajectories, Enrichment analysis of GO and KEGG
Consulting: Statistical consulting, Data analysis, Custom services
Experimental design