Core Facilities & Services Biostatistics/ Bioinformatics

Biostatistics/ Bioinformatics

The mission of the Biostatistics/Bioinformatics Unit is to conduct collaborative research and to provide consultation and quantitative research resources to all IRB Barcelona research groups.

We assist scientists by providing both short and long-term consultancy services in the following areas:

  • Experimental design: sample size, study design, planning of statistical methodology 
  • Data analysis: clinical or biomedical databases, genomics data
  • Assistance with statistical methodology in own or others’ research
  • Software: help in using software, develop software to meet special data analysis or study design needs

The facility conducts methodological research and develops resources in all of the above-mentioned areas.

For more information contact the manager of the Biostatistics/Bioinformatics Unit at 

  • Microarrays: Quality control, Differential expression, Enrichment analysis of GO and KEGG, GSEA GO and KEGG, Signature discovery
  • RNASeq: Quality control, Differential expression, Enrichment analysis of GO and KEGG, Signature discovery, Isoform switching, SNP calling
  • ChipSeq: Processing, Quality control, Peak definition + annotation + visualization, Differential Binding + Integrative analysis
  • Whole Genome Sequencing: Processing, Quality control, SNP calling, Copy number alteration calling
  • Whole Exome Sequencing: Processing, Quality control, SNP calling, Copy number alteration calling
  • Proteomics: Processing, Quality control, Differential expression, Enrichment analysis of GO and KEGG
  • Public database mining and analysis: Selection, Curation of clinical data, Processing of expression data, Association of expression and clinical data, Integration of copy number/genomic data
  • TCGA analysis: Exploratory analysis in all cancer types: association between expression and clinical variables, Detailed analysis with curated clinical and technical variables: association with expression, Data integration: copy number, expression, mutations, etc
  • Microbiome: Quality control + OTU estimation + differential abundance, Phylogenetic analysis
  • Binding prediction: Prediction of binding to RNA/DNA by proteins/genes
  • Single Cell Sequencing: Processing, Quality control, Differential expression, Clustering, Trajectories, Enrichment analysis of GO and KEGG
  • Consulting: Statistical consulting, Data analysis, Custom services
  • Experimental design

Consult the service rates

Cortina C, Turon G, Stork D, Hernando-Momblona X, Sevillano M, Aguilera M, Tosi S, Merlos-Suárez A, Stephan-Otto Attolini C, Sancho E and Batlle E.
EMBO Mol Med, 9 (7), 869-879 (2017)
Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X, Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I and Batlle E.
Cell Stem Cell, 20 (6), 801-816.e7 (2017)
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L and Benitah SA.
Nature, 541 (7635), 41-45 (2017)
Stephan-Otto Attolini C, Peña V and Rossell D.
Bioinformatics, 31 (22), 3631-7 (2015)
Torres AG, Piñeyro D, Rodríguez-Escribà M, Camacho N, Reina O, Saint-Léger A, Filonava L, Batlle E and Ribas de Pouplana L.
Nucleic Acids Res, 43 (10), 5145-57 (2015)
Kessler R, Tisserand J, Font-Burgada J, Reina O, Coch L, Attolini CS, Garcia-Bassets I and Azorín F.
Nat Commun, 6 7049 (2015)
Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello DV, Byrom D, Cortina C, Morral C, Barceló C, Tosi S, Riera A, Attolini CS, Rossell D, Sancho E and Batlle E.
Nat Genet, 47 (4), 320-329 (2015)
Whissell G, Montagni E, Martinelli P, Hernando-Momblona X, Sevillano M, Jung P, Cortina C, Calon A, Abuli A, Castells A, Castellvi-Bel S, Nacht AS, Sancho E, Stephan-Otto Attolini C, Vicent GP, Real FX and Batlle E.
Nat Cell Biol, 16 (7), 695-707 (2014)
Cuartero S, Fresán U, Reina O, Planet E and Espinàs ML.
Embo J, 33 (6), 637-47 (2014)
Font-Burgada J, Reina O, Rossell D and Azorín F.
Nucleic Acids Res, 42 (4), 2126-37 (2014)
Rossell D and Müller P.
Biostatistics, 14 (1), 75-86 (2013)
Johnson, V.E. and Rossell, D.
J Am Stat Assoc, 107 (498), 649-660 (2012)
Planet E, Attolini CS, Reina O, Flores O and Rossell D.
Bioinformatics, 28 (4), 589-90 (2012)
Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R and Batlle E.
Cell Stem Cell, 8 (5), 511-24 (2011)
Johnson VE and Rossell D.
J R Stat Soc B, 72 (2), 143-170 (2010)
Janic A, Mendizabal L, Llamazares S, Rossell D and Gonzalez C.
Science, 330 (6012), 1824-7 (2010)
Font-Burgada J, Rossell D, Auer H and Azorín F.
Gene Dev, 22 (21), 3007-23 (2008)