OncologySignalling and Cell Cycle Laboratory

Signalling and Cell Cycle Laboratory
Group Leader

ICREA Research Professor, ERC Advanced Grant

+34 93 40 31379

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

  1. Mechanisms of signal integration by p38 MAP kinases and their role in cancer
  2. Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.
Igea A and Nebreda AR.
Cancer Res, 75 (19), 3997-4002 (2015)
Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG and Nebreda AR.
Cancer Cell, 25 (4), 484-500 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)
Pereira L, Igea A, Canovas B, Dolado I and Nebreda AR.
EMBO Mol Med, 5 (11), 1759-1774 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (3), 656-657 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (4), 924-925 (2013)
del Barco Barrantes I, Coya JM, Maina F, Arthur JS and Nebreda AR.
P Natl Acad Sci Usa, 108 (31), 12764-9 (2011)
Cuadrado A and Nebreda AR.
Biochem J, 429 (3), 403-17 (2010)

The Signalling and cell cycle laboratory receives financial support from the following sources:

  • European Research Council
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

People

Group news & mentions

20 Apr 2016

The Government of Catalonia has published a news article that summarises the competitiveness of Catalan research centres and universities in the European Research Council (ERC) Call in 2015.

<p>Microscopic structure of mouse testicle tissue (P.Mikolcevic, IRB Barcelona)</p>
30 Mar 2016

Published today in Nature Communications, a study by scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by ICREA researcher Angel R.

Upcoming events

30 Sep
Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Sir Philip Cohen, Ph.D. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences. University of Dundee. Scotland (UK)
03 Oct - 05 Oct
Institut d'Estudis Catalans (IEC), Barcelona
06 Oct
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Prof. Graham Ellis-Davies, Department of Neuroscience, Mount Sinai School of Medicine, NY (USA)