OncologySignalling and Cell Cycle Laboratory

Signalling and Cell Cycle Laboratory
<p>Angel R Nebreda</p>
Group Leader

ICREA Research Professor, ERC Advanced Grant

+34 93 40 31379

The Signalling and Cell Cycle Laboratory focuses on studying the basic mechanisms of cell regulation, especially regarding how external signals are interpreted by cells to modulate cell proliferation, differentiation and survival. Our research centers on two main subjects:

  1. Mechanisms of signal integration by p38 MAP kinases and their role in cancer
  2. Regulation and role of the RINGO/Speedy proteins, a new family of CDK activators.
Trempolec N, Muñoz JP, Slobodnyuk K, Marin S, Cascante M, Zorzano A and Nebreda AR.
Sci Rep, 7 (1), 11367 (2017)
Mikolcevic P, Isoda M, Shibuya H, del Barco Barrantes I, Igea A, Suja JA, Shackleton S, Watanabe Y and Nebreda AR.
Nat Commun, 7 11084 (2016)
Clemente-Ruiz M, Murillo-Maldonado JM, Benhra N, Barrio L, Pérez L, Quiroga G, Nebreda AR and Milán M.
Dev Cell, 36 (3), 290-302 (2016)
Igea A and Nebreda AR.
Cancer Res, 75 (19), 3997-4002 (2015)
Gupta J, del Barco Barrantes I, Igea A, Sakellariou S, Pateras IS, Gorgoulis VG and Nebreda AR.
Cancer Cell, 25 (4), 484-500 (2014)
Urosevic J, Garcia-Albéniz X, Planet E, Real S, Céspedes MV, Guiu M, Fernandez E, Bellmunt A, Gawrzak S, Pavlovic M, Mangues R, Dolado I, Barriga FM, Nadal C, Kemeny N, Batlle E, Nebreda AR and Gomis RR.
Nat Cell Biol, 16 (7), 685-94 (2014)
Pereira L, Igea A, Canovas B, Dolado I and Nebreda AR.
EMBO Mol Med, 5 (11), 1759-1774 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (3), 656-657 (2013)
Trempolec N, Dave-Coll N and Nebreda AR.
Cell, 152 (4), 924-925 (2013)
del Barco Barrantes I, Coya JM, Maina F, Arthur JS and Nebreda AR.
P Natl Acad Sci Usa, 108 (31), 12764-9 (2011)
Cuadrado A and Nebreda AR.
Biochem J, 429 (3), 403-17 (2010)

The Signalling and cell cycle laboratory receives financial support from the following sources:

  • European Research Council
  • Generalitat de Catalunya (Government of Catalonia)
  • Ministerio de Economía y Competitividad (MINECO)
  • European Commission (EC), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa"

     

Group news & mentions

3 Oct 2017

The technology supplement Innovadores of the newspaper El Mundo has echoed on the award of 220,000 euros to three biomedical innovation projects underway at IRB Barcelona.

29 Sep 2017

The Catalan’ Government’s Agency for Management and of University and Research Grants (Agencia de Gestió i Ajuts Universitaris i de Recerca (AGAUR)) has awarded around 220,000 euros to thr

<p>Science Festival 2016, Parc de la Ciutadella.</p>
24 May 2017

This year the Parc de la Ciutadella in Barcelona will be hosting the eleventh edition of the Science Festival.

<p>Researchers revealed details of the p38 activation mechanism. The image represents the structural changes from the inactive state (purple) to the active one (green) proposed by X-ray crystallography. Image: Antonija Kuzmanic.</p>
27 Apr 2017

The protein p38α is a member of a family of molecules that transmit outside signals throughout the cell, thus allowing for an appropriate cell response, such as proliferation, differentiation, sene

Upcoming events

11 Dec
Monday, December 11, Aula Fèlix Serratosa
Speaker:
Richard Gillingwater, Independent Brand Consultant, Fundraiser and Creativity Coach
13 Dec
IRB Meeting Room 1 – IRB Administration Building 1st Floor
Speaker:
Speaker: Georgina Sorrosal, Investment Analyst at Healthequity
13 Dec
Aula Fèlix Serratosa, Parc Científic de Barcelona
Speaker:
Professor Iain Hagan. Cell Division Group Leader, Cancer Research UK Manchester Institute.